Results 131 to 140 of about 5,327 (202)

The role of alternative sigma factor S (σS) and sigma factor B (σB) in bacterial cell stress response and their regulation [PDF]

, 2014
Bacteria successfully take possession of almost every recess of the earth. However bacteria can be liable to big changes of environmental conditions in every settled biotope. Some of them living in a high specializated medium do not show usually ability
Bielecki, Stanisław, Opęchowska, Marzena   +1 more
core  

Modeling delayed processes in biological systems [PDF]

, 2016
Delayed processes are ubiquitous in biological systems and are often characterized by delay differential equations (DDEs) and their extension to include stochastic effects.
Feng, Jingchen, Huang, Bin, Jia, Dongya, Levine, Herbert, Sevier, Stuart   +4 more
core   +2 more sources

Interactions between a subset of substrate side chains and AAA+ motor pore loops determine grip during protein unfolding

eLife, 2019
Most AAA+ remodeling motors denature proteins by pulling on the peptide termini of folded substrates, but it is not well-understood how motors produce grip when resisting a folded domain.
Tristan A Bell, Tania A Baker, Robert T Sauer   +2 more
doaj   +1 more source

Modeling Dynamic Transcriptional Circuits with CRISPRi [PDF]

, 2017
Targeted transcriptional repression with catalytically inactive Cas9 (CRISPRi) can be used to build gene regulatory nets similar in principle to those made with traditional transcription factors, and promises to do so with better orthogonality ...
Clamons, Samuel E., Murray, Richard M.
core   +1 more source

Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells [PDF]

, 2019
Metastatic competence of cancer cells is influenced by many factors including metabolic alterations and changes in mitochondrial biogenesis and protein homeostasis.
Daverey, Amita, Hayward, Stephen, Khalimonchuk, Oleh, Kidambi, Srivatsan, Levytskyy, Roman M., Narasimhan, Madhusudhanan, Ponte Viana, Martonio, Stanke, Kimberly M., Swenson, Samantha   +8 more
core   +1 more source

Novo sistema two-hybrid bacteriano baseado na manipulação da degradação protegida [PDF]

, 2007
Tese de mestrado, Biologia (Biologia Molecular e Genética), 2007, Universidade de Lisboa, Faculdade de CiênciasA expressão de anticorpos intracelulares em eucariotas apresenta um enorme potencial na genómica funcional e na terapia génica.
Oliveira, Soraia Rafaela Santiago de
core  

Engineering ClpXP for Single-Molecule Protein Sequencing [PDF]

Biophysical Journal, 2017
Mike Filius, Jetty van Ginkel, Chirlmin Joo   +2 more
openaire   +1 more source

Caseinolytic mitochondrial matrix peptidase X is essential for homologous chromosome synapsis and recombination during meiosis of male mouse germ cells

Asian Journal of Andrology
Meiosis is the process of producing haploid gametes through a series of complex chromosomal events and the coordinated action of various proteins. The mitochondrial protease complex (ClpXP), which consists of caseinolytic mitochondrial matrix peptidase X
Hai-Wei Feng, Yu Zhao, Yan-Ling Gao, Dong-Teng Liu, Li-Jun Huo   +4 more
doaj   +1 more source

Deletion of heat shock protein 60 in adult mouse cardiomyocytes perturbs mitochondrial protein homeostasis and causes heart failure. [PDF]

, 2020
To maintain healthy mitochondrial enzyme content and function, mitochondria possess a complex protein quality control system, which is composed of different endogenous sets of chaperones and proteases.
Chen, Ju, Duan, Yaoyun, Fan, Feifei, Fang, Xi, Huang, Lei, Jia, Nan, Li, Yali, Liu, Jie, Ouyang, Kunfu, Tang, Huayuan, Trexler, Christa, Wang, Gang, Wang, Hong, Yang, Feili   +13 more
core  

Design and synthesis of novel inhibitors for human protease ClpXP and substrate identification of human and S. aureus ClpXP

, 2022
ClpP is a barrel-shaped serine protease, composed of two heptameric rings that forms a proteolytically active complex with ATP-dependent chaperone ClpX. In this thesis, a novel inhibitor class for human ClpXP is described that showed promising anti-proliferative activity against cancer cells.
openaire   +1 more source