Results 121 to 130 of about 3,616 (191)

Caseinolytic mitochondrial matrix peptidase X is essential for homologous chromosome synapsis and recombination during meiosis of male mouse germ cells

Asian Journal of Andrology
Meiosis is the process of producing haploid gametes through a series of complex chromosomal events and the coordinated action of various proteins. The mitochondrial protease complex (ClpXP), which consists of caseinolytic mitochondrial matrix peptidase X
Hai-Wei Feng, Yu Zhao, Yan-Ling Gao, Dong-Teng Liu, Li-Jun Huo   +4 more
doaj   +1 more source

Pharmacological Inhibition of the ClpXP Protease Increases Bacterial Susceptibility to Host Cathelicidin Antimicrobial Peptides and Cell Envelope-Active Antibiotics

, 2012
The ClpXP protease is a critical bacterial intracellular protease that regulates protein turnover in many bacterial species. Here we identified a pharmacological inhibitor of the ClpXP protease, F2, and evaluated its action in Bacillus anthracis and ...
Tran, Dan N., Okumura, Cheryl Y., Keiler, Kenneth C., Zhang, Dawn X., Alumasa, John N., McGillivray, Shauna M., Sakoulas, George, Ramadoss, Nitya S., Nizet, Victor, Vaughn, Micah M.   +9 more
core   +1 more source

Dissecting the steps of substrate processing by the energy-dependent protease ClpXP

, 2004
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2004.Includes bibliographical references.Intracellular proteolysis is carried out by self-compartmentalized, energy dependent proteases which contain a regulatory and a proteolytic
Siddiqui, Samia M. (Siddiqui Mohammed), 1977-
core  

Engineering ClpXP for Single-Molecule Protein Sequencing [PDF]

Biophysical Journal, 2017
Mike Filius, Jetty van Ginkel, Chirlmin Joo   +2 more
openaire   +1 more source

CLIPPERs - Clip the right protein – a new tool for targeted proteolysis in bacteria

EMBO Reports
Despite antibiotics, bacterial infections still represent a major challenge to human health as bacteria have been developing resistance to most of the currently available antibiotics.
Marta Carroni
doaj   +1 more source

Observing the effect of oxidative stress on ClpXP

, 2020
Jennifer Fishovitz, Emma Kelley
openaire   +1 more source

A proteolytic AAA+ machine poised to unfold protein substrates

Nature Communications
AAA+ proteolytic machines unfold proteins before degrading them. Here, we present cryoEM structures of ClpXP-substrate complexes that reveal a postulated but heretofore unseen intermediate in substrate unfolding/degradation. A ClpX hexamer draws natively
Alireza Ghanbarpour, Robert T. Sauer, Joseph H. Davis   +2 more
doaj   +1 more source

POST-TRANSLATIONAL REGULATION OF THE rpoS AND psrA GENES IN Pseudomonas putida WCS358: THE ROLE OF ClpXP PROTEASE

, 2014
— The RpoS and PsrA proteins are key transcriptional regulators that are activated in response to the stationary phase of growth in pseudomonads. This study was designed to establish whether ClpXP (ATP-dependent serine protease) regulates levels of RpoS ...
B. Jovčić, Jelena Begović, Jelena Lozo, L. Topisirović, M. Kojić   +4 more
core  

An adaptor for feedback regulation of heme biosynthesis by a mitochondrial protease. [PDF]

Science
Cottle T, Joh L, Posner C, DeCosta A, Campagna DR, Fleming MD, Ducamp S, Kardon JR.   +7 more
europepmc   +1 more source

A mitochondrial insertion directs substrate selection and engagement by the protein unfoldase ClpX. [PDF]

J Biol Chem
DeCosta A, Barrick R, Kardon JR.
europepmc   +1 more source