Frontiers in Molecular Biosciences, 2015 In Escherichia coli, σS is the master regulator of the general stress response. The level of σS changes in response to multiple stress conditions and it is regulated at many levels including protein turnover.
Dimce eMicevski +3 more
doaj +1 more source
A Bacterial Toxin Inhibits DNA Replication Elongation through a Direct Interaction with the β Sliding Clamp [PDF]
, 2013 Toxin-antitoxin (TA) systems are ubiquitous on bacterial chromosomes, yet the mechanisms regulating their activity and the molecular targets of toxins remain incompletely defined.
Aakre, Christopher David +3 more
core +1 more source
ClpXP and ClpAP control the Escherichia coli division protein ZapC by proteolysis
Microbiology, 2016 The bacterial FtsZ-ring is an essential cytokinetic structure under tight spatiotemporal regulation. In Escherichia coli, FtsZ polymerization and assembly into the Z-ring is controlled on multiple levels through interactions with positive and negative regulators.
Monika S, Buczek +2 more
openaire +2 more sources
Interferon Stimulated Gene Expression Is a Biomarker for Primary Mitochondrial Disease
Annals of Neurology, Volume 96, Issue 6, Page 1185-1200, December 2024.Objective Mitochondria are implicated in regulation of the innate immune response. We hypothesized that abnormalities in interferon signaling may contribute to pathophysiology in patients with primary mitochondrial disease (PMD). Methods Expression of interferon stimulated genes (ISGs) was measured by real‐time polymerase chain reaction (PCR) in whole ...
Nandaki Keshavan +3 more
wiley +1 more source
Queueing up for enzymatic processing: correlated signaling through coupled degradation
Molecular Systems Biology, 2011 High‐throughput technologies have led to the generation of complex wiring diagrams as a post‐sequencing paradigm for depicting the interactions between vast and diverse cellular species. While these diagrams are useful for analyzing biological systems on
Natalie A Cookson +6 more
doaj +1 more source
Stochastic Gene Expression in Single Gene Oscillator Variants [PDF]
, 2016 It is infeasible to understand all dynamics in cell, but we can aim to understand the impact of design choices under our control. Here we consider a single gene oscillator as a case study to understand the influence of DNA copy number and repressor ...
Bennett, Matthew R. +4 more
core
How to Regulate a Gene: To Repress or to Activate? [PDF]
, 2012 Gene-expression responses to an input can depend on growth conditions; in this issue, Sasson et al.
Slavov, Nikolai +2 more
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Eine Photocrosslinker Sonde zur Erfassung der Substrate der caseinolytischen Protease P
Angewandte Chemie, Volume 136, Issue 46, November 11, 2024.Hier stellen wir eine in situ Trappingstrategie vor, die trifunktionale Sonden verwendet, welche an das Serin im aktiven Zentrum der tetradekameren caseinolytischen Protease P (ClpP) binden und bei UV‐Bestrahlung Substrate innerhalb der proteolytischen Kammer von ClpP durch UV‐Licht induzierte Quervernetzung einfangen.
Thomas F. Gronauer +3 more
wiley +1 more source
TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching. [PDF]
, 2015 The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family.
Corbett, Kevin D +5 more
core +2 more sources
From ingestion to colonization: the influence of the host environment on regulation of the LEE encoded type III secretion system in enterohaemorrhagic Escherichia coli [PDF]
, 2015 Enterohaemorrhagic Escherichia coli (EHEC) binds to host tissue and intimately attaches to intestinal cells using a dedicated type III secretion system (T3SS). This complex multi-protein organelle is encoded within a large pathogenicity island called the
Connolly, J.P., Finlay, B.B., Roe, A.J.
core +1 more source