Results 101 to 110 of about 5,327 (202)

The mitochondrial protease ClpP is a druggable target that controls VSMC phenotype by a SIRT1-dependent mechanism

Redox Biology
Vascular smooth muscle cells (VSMCs), known for their remarkable lifelong phenotypic plasticity, play a pivotal role in vascular pathologies through their ability to transition between different phenotypes. Our group discovered that the deficiency of the
Felipe Paredes, Holly C. Williams, Xuesong Liu, Claire Holden, Bethany Bogan, Yu Wang, Kathryn M. Crotty, Samantha M. Yeligar, Alvaro A. Elorza, Zhiyong Lin, Amir Rezvan, Alejandra San Martin   +11 more
doaj   +1 more source

ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP

eLife, 2020
AAA+ proteases perform regulated protein degradation in all kingdoms of life and consist of a hexameric AAA+ unfoldase/translocase in complex with a self-compartmentalized peptidase.
Sora Kim, Kristin L Zuromski, Tristan A Bell, Robert T Sauer, Tania A Baker   +4 more
doaj   +1 more source

ClpXP protease degrades the cytoskeletal protein, FtsZ, and modulates FtsZ polymer dynamics [PDF]

Proceedings of the National Academy of Sciences, 2009
FtsZ is the major cytoskeletal protein in bacteria and a tubulin homologue. It polymerizes and forms a ring where constriction occurs to divide the cell. We found that FtsZ is degraded by E. coli ClpXP, an ATP-dependent protease.
Jodi L, Camberg, Joel R, Hoskins, Sue, Wickner   +2 more
openaire   +2 more sources

Serine and Threonine Phosphorylation Marks Proteins for Degradation By Clpxp

Blood, 2021
Abstract The mitochondrial serine protease, ClpXP, regulates the integrity of the respiratory chain by degrading damaged and/or misfolded proteins. This protease is over-expressed in a subset of AML and inhibiting or hyperactivating it kills leukemic cells and stem cells in vitro and in vivo.
Yue Feng, Yulia Jitkova, Harjeet Soor, Suzanne Trudel, Kaitlin Lees, Kaylen Soriano, Siavash Vahidi, Andrei Yudin, Aaron D Schimmer   +8 more
openaire   +1 more source

Tag-Dependent Substrate Selection of ClpX Underlies Secondary Differentiation of Chlamydia trachomatis

mBio, 2022
Despite having a highly reduced genome, Chlamydia trachomatis undergoes a complex developmental cycle in which the bacteria differentiate between the following two functionally and morphologically distinct forms: the infectious, nonreplicative elementary
Nicholas A. Wood, Abigail R. Swoboda, Amanda M. Blocker, Derek J. Fisher, Scot P. Ouellette   +4 more
doaj   +1 more source

The ClpP protease homologue is required for the transmission traits and cell division of the pathogen Legionella pneumophila [PDF]

, 2010
Background Legionella pneumophila, the intracellular bacterial pathogen that causes Legionnaires' disease, exhibit characteristic transmission traits such as elevated stress tolerance, shortened length and virulence during the transition from the ...
Xiang-hui Li, Yong-lun Zeng, Ye Gao, Xiao-cong Zheng, Qin-fen Zhang, Shi-ning Zhou, Yong-jun Lu   +6 more
core   +2 more sources

Autophagy and the Mitochondrial Lon1 Protease Are Necessary for Botrytis cinerea Heat Adaptation

Molecular Microbiology, Volume 124, Issue 4, Page 358-369, October 2025.
The destabilization of mitochondria due to the disruption of the Lon1 protease induces cellular damage, including reactive oxygen species (ROS) accumulation, impaired germination, and growth arrest. Activation of autophagy inhibits fungal growth and recycles damaged cellular components, potentially serving as a cytoprotective role downstream of the ...
Mingzhe Zhang, Liang Ma, Zhiqun Lyu, Naomi Kagan Trushina, Amir Sharon   +4 more
wiley   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, Volume 19, Issue 9, Page 2648-2669, September 2025.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Rapid cell-free forward engineering of novel genetic ring oscillators [PDF]

, 2015
While complex dynamic biological networks control gene expression in all living organisms, the forward engineering of comparable synthetic networks remains challenging. The current paradigm of characterizing synthetic networks in cells results in lengthy
Hori, Yutaka, Maerkl, Sebastian J., Murray, Richard M., Niederholtmeyer, Henrike, Sun, Zachary Z., Verpoorte, Amanda, Yeung, Enoch   +6 more
core   +2 more sources

Adaptive Tolerance of Listeria monocytogenes to Chemical Oxidants: Comparative Analysis of Transcriptomic Studies

Comprehensive Reviews in Food Science and Food Safety, Volume 24, Issue 5, September 2025.
ABSTRACT Listeria monocytogenes is a foodborne pathogen that poses significant challenges to food safety and public health due to its ability to adapt to harsh environments, particularly those found in food processing facilities. This review explores the global transcriptional responses of L.
Nagendran Rajalingam, Sam Van Haute
wiley   +1 more source