Results 71 to 80 of about 1,957,946 (299)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

КОНЦЕПТУАЛЬНЫЕ И МЕТОДОЛОГИЧЕСКИЕ ОСНОВЫ УПРАВЛЕНИЯ ЭКОНОМИКО-СОЦИАЛЬНЫМИ СИСТЕМАМИ ДЛЯ РЕАЛИЗАЦИИ КЛАСТЕРНОЙ ПОЛИТИКИ В ОТРАСЛИ ЖКХ

Sovremennye Issledovaniâ Socialʹnyh Problem, 2015
В статье впервые рассмотрены и проанализированы практически все существующие парадигмы и теории управления социально-экономическими системами, наиболее полно позволяющие реализовать и объяснить существование кластерного подхода в социально важной сфере ...
Leyla Borisovna Leonova
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Faktor yang Mempengaruhi Pengembangan Klaster Batik Laweyan-Surakarta Menuju Ekonomi Lokal Berkelanjutan

Jurnal Wilayah dan Lingkungan, 2013
Condition of economics of Kampung Batik Laweyan Surakarta as Klaster economics still have not good enough yet compared to a period of its glory in 1970 though there are improvements since 2004.
Abdul Muin
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Leveraging uncertainty in collective opinion dynamics with heterogeneity

Scientific Reports
Natural and artificial collectives exhibit heterogeneities across different dimensions, contributing to the complexity of their behavior. We investigate the effect of two such heterogeneities on collective opinion dynamics: heterogeneity of the quality ...
Vito Mengers, Mohsen Raoufi, Oliver Brock, Heiko Hamann, Pawel Romanczuk   +4 more
doaj   +1 more source

Networking on the utilization of local natural resources

Apstract: Applied Studies in Agribusiness and Commerce, 2010
Together with its partners, Szolnok College is planning to evaluate a new project for networking on the utilization of local natural resources. This project is based on a research work (using the findings of the surveys completed by the representatives ...
Katalin Herbály-Hekli
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A Solitary Osteochondroma Originating from the Spinous Process of the Third Cervical Vertebra: A Case Report and Comprehensive Literature Review

Journal of Spine Practice
Background Osteochondroma is one of the most common solitary bone lesions. Multiple lesions are possible only in some genetic abnormalities, such as hereditary multiple exostoses (HME).
Jinan Mohammed Aljasem, Abdulaziz Yousef Alahmed, Osama Abdullah Barnawi, Ghaida Ali Aljdhaa, Abdullah Salem Almalki, Ahmed Bin Ali Albinali, Ali Hussain Dallak, Jehad Mahmoud Ahmed, Abdullah Qaddah Alqahtani   +8 more
doaj   +1 more source

The Development of Small and Medium Entreprises Clusters in Indonesia

Gadjah Mada International Journal of Business, 2004
Small and Medium Enterprises (SMEs) in Indonesia are very important not only for employment creation, but also as important sources of economic growth and foreign currencies generation through exports. Since the early 1980s, the Indonesian government has
Tulus Tambunan, Hendrawan Supratikno
doaj   +1 more source