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Clustered DNA damage induced by protons radiation in plasmid DNA [PDF]

Science Bulletin, 2013
Clustered DNA damage is considered as a critical type of lesions induced by ionizing radiation, which can be converted into the fatal or strong mutagenic complex double strand breaks (DSBs) during damage processing in the cells. The new data show that high energy protons produce more potentially lethal DSBs than low LET radiation.
Li Sui, Fuquan Kong, Ping-Kun Zhou
exaly   +2 more sources

Significance of DNA polymerase I in in vivo processing of clustered DNA damage

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2013
We examined the biological consequences of bi-stranded clustered damage sites, consisting of a combination of DNA lesions, such as a 1-nucleotide gap (GAP), an apurinic/apyrimidinic (AP) site, and an 8-oxo-7,8-dihydroguanine (8-oxoG), using a bacterial plasmid-based assay.
Naoya Shikazono, Ken Akamatsu, Miho Noguchi   +2 more
exaly   +5 more sources

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Condensation of DNA—A putative obstruction for repair process in abasic clustered DNA damage

DNA Repair, 2013
Clustered DNA damages are defined as two or more closely located DNA damage lesions that may be present within a few helical turns of the DNA double strand. These damages are potential signatures of ionizing radiation and are often found to be repair resistant. Types of damaged lesions frequently found inside clustered DNA damage sites include oxidized
Vandana Singh, Prolay Das
exaly   +3 more sources

Radiation Induced Clustered Damage in DNA

Free Radical Research Communications, 1989
(1989). Radiation Induced Clustered Damage in DNA. Free Radical Research Communications: Vol. 6, No. 2-3, pp. 177-178.
U, Hagen, H, Bertram, E M, Geigl, E, Kohfeldt, S, Wendel   +4 more
openaire   +2 more sources

Repair of clustered damage and DNA polymerase iota

Biochemistry (Moscow), 2015
Multiple DNA lesions occurring within one or two turns of the DNA helix known as clustered damage are a source of double-stranded DNA breaks, which represent a serious threat to the cells. Repair of clustered lesions is accomplished in several steps.
E A, Belousova, O I, Lavrik
openaire   +2 more sources

Clustered DNA damage on subcellular level: effect of scavengers

Radiation and Environmental Biophysics, 2014
Clustered DNA damages are induced by ionizing radiation, particularly of high linear energy transfer (LET). Compared to isolated DNA damage sites, their biological effects can be more severe. We investigated a clustered DNA damage induced by high LET radiation (C 290 MeV u(-1) and Fe 500 MeV u(-1)) in pBR322 plasmid DNA.
Kateřina, Pachnerová Brabcová, Lembit, Sihver, Nakahiro, Yasuda, Youichirou, Matuo, Václav, Stěpán, Marie, Davídková   +5 more
openaire   +2 more sources

Are endogenous clustered dna damages induced in human cells?

Free Radical Biology and Medicine, 2004
Although clustered DNA damages are induced in cells by ionizing radiation and can be induced artifactually during DNA isolation, it was not known if they are formed in unirradiated cells by normal oxidative metabolism. Using high-sensitivity methods of quantitative gel electrophoresis, electronic imaging, and number average length analysis, we found ...
Paula V, Bennett, Nela S, Cintron, Laurent, Gros, Jacques, Laval, Betsy M, Sutherland   +4 more
openaire   +2 more sources

Contribution of indirect effects to clustered damage in DNA irradiated with protons

Radiation Protection Dosimetry, 2015
Protons are the dominant particles both in galactic cosmic rays and in solar particle events and, furthermore, proton irradiation becomes increasingly used in tumour treatment. It is believed that complex DNA damage is the determining factor for the consequent cellular response to radiation. DNA plasmid pBR322 was irradiated at U120-M cyclotron with 30
K, Pachnerová Brabcová, V, Štěpán, M, Karamitros, M, Karabín, P, Dostálek, S, Incerti, M, Davídková, L, Sihver   +7 more
openaire   +2 more sources

Clustered DNA Damages Induced by X Rays in Human Cells

Radiation Research, 2002
Although DNA DSBs are known to be important in producing the damaging effects of ionizing radiation in cells, bistranded clustered DNA damages-two or more oxidized bases, abasic sites or strand breaks on opposing DNA strands within a few helical turns-are postulated to be difficult to repair and thus to be critical radiation-induced lesions. Gamma rays
Betsy M, Sutherland, Paula V, Bennett, John C, Sutherland, Jacques, Laval   +3 more
openaire   +2 more sources