Results 201 to 210 of about 3,146,198 (232)

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Toward a Conceptual Multiscale Framework for Predictive Radiobiology: Integrating Genomic Damage, Network Rewiring, and Tissue Microenvironment. [PDF]

Int J Mol Sci
Son TG.
europepmc   +1 more source

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

The Converging Roles of DNA Damage Resolution and Redox Dysregulation in Plasma Cell Transformation During the Evolution of Multiple Myeloma. [PDF]

Int J Mol Sci
Malamos P, Koutoulogenis K, Gavriatopoulou M, Terpos E, Souliotis VL.   +4 more
europepmc   +1 more source

A Microcapsule‐Integrated smRandom‐seq Platform Enables Fixation‐Free Single Microbe RNA Sequencing

Advanced Science, EarlyView.
We developed a microcapsule‐integrated high‐throughput fixation‐free single‐microbe RNA‐seq workflow in which microbes are encapsulated in aqueous two‐phase microcapsules for physical confinement of nucleic acids. This platform enables co‐encapsulation with barcoded beads for sequencing and reveals that fixation‐free processing enhances transcriptomic ...
Mengdi Song, Yuting Wang, Zhaolun Wang, Shunji Zhang, Zhengmin Tang, Yongcheng Wang   +5 more
wiley   +1 more source

Apoptosis-driven chromosomal rearrangements in cancer: CAD cleavage, nuclear architecture, and microhomology-mediated end joining. [PDF]

Oncogenesis
Tan SN.
europepmc   +1 more source

Kinetic Control of Condensate Function: How the Formation Dynamics of APBs Influence ALT Cancer Telomere Length Heterogeneity. [PDF]

Bioessays
Zhang H.
europepmc   +1 more source

Auger-Emitting Radionuclides in Radiopharmaceutical Research: Decay-Associated Processes, Vector-Dependent Localization, and Translational Perspectives. [PDF]

Int J Mol Sci
Schomäcker K, Sudbrock F, Freifrau von Brandenstein M, Akgül B, Hufbauer M, Fischer T, Sahnoun SEM, Dietlein F, Krapf P, Dietlein M, Drzezga A.   +10 more
europepmc   +1 more source

Aryl hydrocarbon receptor is involved in DNA damage repair after liver injury with diethylnitrosamine in mice. [PDF]

Mol Biomed
Marín-Díaz B, González-Rico FJ, Ordóñez-Mata L, Román ÁC, Merino JM, Fernández-Salguero PM.   +5 more
europepmc   +1 more source