Results 211 to 220 of about 86,380 (239)

Effect of Hydroxyl Radical Scavenging Capacity on Clustering of DNA Damage

Radiation Research, 1997
We have shown previously that the thiol N-(2'-mercaptoethyl)-1,3-diaminopropane (WR-1065) can attenuate the formation of strand breaks associated with ionizing radiation. The mechanism of this protection is predominantly the reduction of DNA radical species which otherwise would attenuate the chemical repair of DNA radical species which are strand ...
J R, Milligan, J A, Aguilera, C C, Wu, R A, Paglinawan, T T, Nguyen, D, Wu, J F, Ward   +6 more
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A nanodosimetric model of radiation-induced clustered DNA damage yields

Physics in Medicine and Biology, 2010
We present a nanodosimetric model for predicting the yield of double strand breaks (DSBs) and non-DSB clustered damages induced in irradiated DNA. The model uses experimental ionization cluster size distributions measured in a gas model by an ion counting nanodosimeter or, alternatively, distributions simulated by a Monte Carlo track structure code ...
Garty, G., Schulte, R., Shchemelinin, S., Leloup, Corinne, Assaf, G., Breskin, A., Chechik, R., Bashkirov, V., Miligan, J., Grosswendt, B.   +9 more
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Clustered DNA Damage and its Complexity: Tracking the History

Radiation Research
The concept of radiation-induced clustered damage in DNA has grown over the past several decades to become a topic of considerable interest across the scientific disciplines involved in studies of the biological effects of ionizing radiation. This paper, prepared for the 70th anniversary issue of Radiation Research, traces historical development of the
Dudley T, Goodhead, Michael, Weinfeld
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Oxidatively generated complex DNA damage: Tandem and clustered lesions

Cancer Letters, 2012
There is an increasing interest for oxidatively generated complex lesions that are potentially more detrimental than single oxidized nucleobases. In this survey, the recently available information on the formation and processing of several classes of complex DNA damage formed upon one radical hit including mostly hydroxyl radical and one-electron ...
Cadet, J., Ravanat, J.-L., Taverna Porro, M., Menoni, H., Angelov, D.   +4 more
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Improvement of the local effect model (LEM)—implications of clustered DNA damage

Radiation Protection Dosimetry, 2006
An improvement of the Local Effect Model (LEM) is presented which takes clustered DNA damage into account. Single strand breaks (SSBs) and double strand breaks (DSBs) are distributed stochastically onto the DNA molecule and additional DSBs are recorded.
Th, Elsässer, M, Scholz
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Endogenous DNA damage clusters in human hematopoietic stem and progenitor cells

Free Radical Biology and Medicine, 2008
Clustered DNA damages-multiple oxidized bases, abasic sites, or strand breaks within a few helical turns-are potentially mutagenic and lethal alterations induced by ionizing radiation. Endogenous clusters are found at low frequencies in unirradiated normal human cells and tissues. Radiation-sensitive hematopoietic cells with low glycosylase levels (TK6
Paula, Bennett, Alexander A, Ishchenko, Jacques, Laval, Brigitte, Paap, Betsy M, Sutherland   +4 more
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Clustered DNA Damages as Dosemeters for Ionising Radiation Exposure and Biological Responses

Radiation Protection Dosimetry, 2001
Clustered DNA damages--two or more lesions (oxidised bases. abasic sites, or strand breaks) within a few DNA helical turns on opposing strands--are induced in DNA in solution and in vivo in human cells by ionising radiation. They have been postulated to be difficult to repair, and thus of potentially high biological significance.
B M, Sutherland, P V, Bennett, M, Saparbaev, J C, Sutherland, J, Laval   +4 more
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Investigation of Groove Damage Distribution in Proton‐Induced Clustered B‐ DNA Damage

Environmental and Molecular Mutagenesis
ABSTRACT Accurate measurement of DNA damage is critical for therapeutic optimization in proton‐based targeted radiotherapy. This research pioneered the first investigation into the groove damage distribution mechanism in clustered B‐DNA damage induced by proton radiation.
Shanshan Bao, Guang Hu, Chao Wang, Weiqiang Sun, Huasi Hu   +4 more
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Dynamics of DNA Double-Strand Breaks Revealed by Clustering of Damaged Chromosome Domains

Science, 2004
Interactions between ends from different DNA double-strand breaks (DSBs) can produce tumorigenic chromosome translocations. Two theories for the juxta-position of DSBs in translocations, the static “contact-first” and the dynamic “breakage-first” theory, differ fundamentally in their requirement for DSB mobility.
Aten, Jacob A., Stap, Jan, Krawczyk, Przemek M., van Oven, Carel H., Hoebe, Ron A., Essers, Jeroen, Kanaar, Roland   +6 more
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Processing of DNA damage clusters in human cells: current status of knowledge

Molecular BioSystems, 2007
Abstract Eukaryotic cells exposed to DNA damaging agents activate important defensive pathways by inducing multiple proteins involved in DNA repair, cell cycle checkpoint control and potentially apoptosis. After the acceptance of the hypothesis that oxidatively generated clustered DNA lesions (OCDL: closely spaced DNA lesions) can be ...
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