Results 31 to 40 of about 161,459 (317)
Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA-PK. [PDF]
Nucleic Acids Res, 2013 DNA double-strand breaks (DSB) are considered as the most deleterious DNA lesions, and their repair is further complicated by increasing damage complexity. However, the molecular effects of clustered lesions are yet not fully understood. As the locally restricted phosphorylation of H2AX to form γH2AX is a key step in facilitating efficient DSB repair ...
Meyer B +5 more
europepmc +5 more sources
Xeroderma Pigmentosum Group A Suppresses Mutagenesis Caused by Clustered Oxidative DNA Adducts in the Human Genome. [PDF]
PLoS ONE, 2015 Clustered DNA damage is defined as multiple sites of DNA damage within one or two helical turns of the duplex DNA. This complex damage is often formed by exposure of the genome to ionizing radiation and is difficult to repair. The mutagenic potential and
Akira Sassa +4 more
doaj +1 more source
Molecules, 2021 Different types of DNA lesions forming in close vicinity, create clusters of damaged sites termed as “clustered/complex DNA damage” and they are considered to be a major challenge for DNA repair mechanisms resulting in significant repair delays and ...
Athanasia Pavlopoulou +8 more
doaj +1 more source
Saccharomyces cerevisiae-based system for studying clustered DNA damages [PDF]
Radiation and Environmental Biophysics, 2010 DNA-damaging agents can induce clustered lesions or multiply damaged sites (MDSs) on the same or opposing DNA strands. In the latter, attempts to repair MDS can generate closely opposed single-strand break intermediates that may convert non-lethal or mutagenic base damage into double-strand breaks (DSBs). We constructed a diploid S.
Moscariello, Mario, Sutherland, Betsy
openaire +2 more sources
Repair of clustered uracil DNA damages in Escherichia coli [PDF]
Nucleic Acids Research, 2003 Multiply damaged sites (MDS) are defined as greater than/equal to two lesions within 10-15 bp and are generated in DNA by ionizing radiation. In vitro repair of closely opposed base damages > or =2 bp apart results in a double strand break (DSB). This work extends the in vitro studies by utilizing clusters of uracil DNA damage as model lesions to ...
Dwain I, D'souza, Lynn, Harrison
openaire +2 more sources
Quantitative characteristics of clustered DNA damage in irradiated cells by heavy ion beams [PDF]
J Radiat Res, 2014 Terato H +3 more
europepmc +3 more sources
Cells, 2023 Background: Heavy ion irradiation (IR) with high-linear energy transfer (LET) is characterized by a unique depth dose distribution and increased biological effectiveness.
Mutaz A. Abd Al-razaq +3 more
doaj +1 more source
Clustered DNA damage induced by protons radiation in plasmid DNA [PDF]
Chinese Science Bulletin, 2013 Clustered DNA damage is considered as a critical type of lesions induced by ionizing radiation, which can be converted into the fatal or strong mutagenic complex double strand breaks (DSBs) during damage processing in the cells. The new data show that high energy protons produce more potentially lethal DSBs than low LET radiation.
Sui, Li +5 more
openaire +1 more source
DNA damage induced during mitosis undergoes DNA repair synthesis. [PDF]
, 2020 Understanding the mitotic DNA damage response (DDR) is critical to our comprehension of cancer, premature aging and developmental disorders which are marked by DNA repair deficiencies.
Berns, Michael W +10 more
core +1 more source
Production of Clustered DNA Damage by125I Decay
Acta Oncologica, 2000 Linda S. Yasui +2 more
openalex +3 more sources