Results 231 to 240 of about 96,622 (267)

Design and molecular insights of drug-active metabolite based co-amorphous formulation: A case study of toltrazuril-ponazuril co-amorphous

International Journal of Pharmaceutics, 2022
Co-amorphous supersaturated drug delivery systems are emerging as an alternative strategy to improve the water solubility of BCS II drugs. Typically, the supersaturation and stability of co-amorphous systems largely depend on the type of employed co-former.
Bin, Li, Yingyun, Wang, Ying, Feng, Dan, Yuan, Renjie, Xu, Cuiping, Jiang, Xuecheng, Xiao, Shan, Lu   +7 more
openaire   +2 more sources

Dipeptides as co-formers in co-amorphous systems

European Journal of Pharmaceutics and Biopharmaceutics, 2019
Drug-amino acid co-amorphous systems have become increasingly well-investigated systems to improve dissolution rate of poorly water-soluble drugs. In this study, dipeptides were investigated as co-formers for co-amorphous systems based on the hypothesis that dipeptides might combine the inherent properties of the two included amino acids.
Wu, Wenqi, Löbmann, Korbinian, Schnitzkewitz, Jan, Knuhtsen, Astrid, Pedersen, Daniel Sejer, Rades, Thomas, Grohganz, Holger   +6 more
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Silicide formation in Co/amorphous Si multilayers

Journal of Applied Physics, 1994
We studied interfacial reactions in Co/amorphous Si(a-Si) multilayers by transmission electron microscopy. We found that an intermixed layer of amorphous cobalt silicide formed in the as-deposited state. To explain the solid-state amorphization reaction, two parameters were used.
W. H. Wang, W. K. Wang
openaire   +1 more source

Sm–Co Amorphous Film with Perpendicular Anisotropy

Japanese Journal of Applied Physics, 1983
It is very difficult to prepare Sm–Co ferromagnetic film with perpendicular anisotropy, though RE–TM ferrimagnetic films with perpendicular anisotropy are well prepared (RE: rare earth, TM: transition metal). Because of the exceptional magnetic properties of Sm–Co magnetic film as magnetic recording media, we studied to prepare Sm–Co magnetic film ...
Zo-Yi Lee, Takuhisa Numata, Yoshifumi Sakurai   +2 more
openaire   +1 more source

Magnetic anisotropy of Tb-Co amorphous films

Physics of the Solid State, 2011
A systematic investigation of the magnetic properties of Tb-Co amorphous films prepared using radio-frequency ion sputtering in a uniform magnetic field has been carried out. The main regularities of the change in the magnetic anisotropy parameters as a function of the composition (8–43 at % Tb), measurement temperature (5–350 K), and annealing ...
V. R. Vaskovskiy, K. G. Balymov, A. V. Svalov, N. A. Kulesh, E. A. Stepanova, A. N. Sorokin   +5 more
openaire   +1 more source

Aspartame as a co-former in co-amorphous systems

International Journal of Pharmaceutics, 2018
Co-amorphous drug delivery systems are a promising approach to improve the dissolution rate and therefore potentially the oral bioavailability of poorly-water soluble drugs. Several low molecular weight excipients, for instance amino acids, have previously been shown to stabilize the amorphous form and increase the dissolution rate of drugs.
Wenqi Wu, Korbinian Löbmann, Jan Schnitzkewitz, Astrid Knuhtsen, Daniel Sejer Pedersen, Holger Grohganz, Thomas Rades   +6 more
openaire   +3 more sources

Co-Amorphous Telmisartan-Pimelic Acid with Improved Solubility

Materials Science Forum, 2020
Telmisartan (TEL), a type of antihypertensive drug, has poor solubility. To improve its solubility, the co-amorphous telmisartan with pimelic acid (PA) in molar ratio of 1:1 and 2:1, respectively, were obtained using a liquid-assisted grinding method.
Ze Xin Wu, Wen Zhe Ma, Lei Wang, Chang Lin Yao, Shuang Song, Xin Yuan Wang   +5 more
openaire   +1 more source

Stability of Co-amorphous Solid Dispersions: Physical and Chemical Aspects

Журнал структурной химии, 2023
Drug amorphization is one of the major approaches in pharmaceutical sciences to improve the solubility and dissolution rate of poorly water-soluble drugs. Amorphous solid dispersions are widely discussed approach to convert the drug into an amorphous state but due to its high energy state, the system tends to recrystallize upon storage.
Abhijeet A. Aher, Karimunnisa S. Shaikh, Praveen D. Chaudhari   +2 more
openaire   +1 more source

Transformations between Co-Amorphous and Co-Crystal Systems and Their Influence on the Formation and Physical Stability of Co-Amorphous Systems

Molecular Pharmaceutics, 2019
The formation of co-amorphous and co-crystal systems are attractive formulation strategies for poorly water-soluble drugs. Intermolecular interactions between the drug and the coformer(s) play an important role in the formation of both systems, making the investigation of transformations between the two systems specifically interesting. The aim of this
Wenqi Wu, Yixuan Wang, Korbinian Löbmann, Holger Grohganz, Thomas Rades   +4 more
openaire   +3 more sources

Spontaneous Spin Reorientation in Gd–Co Amorphous Films

Physics of Metals and Metallography, 2019
The phenomenon of spontaneous spin reorientation in Gd–Сo amorphous films, which results from the competition between the perpendicular magnetic anisotropy and shape anisotropy, is studied. It is shown that the reorientation occurs via the formation of a fine-grained nonuniform magnetic structure called hypercritical state in a wide temperature range ...
V. O. Vas’kovskii, A. N. Gor’kovenko, O. A. Adanakova, A. V. Svalov, N. A. Kulesh, E. A. Stepanova, E. V. Kudyukov, V. N. Lepalovskii   +7 more
openaire   +1 more source