Compaction Behavior of Co-Amorphous Systems [PDF]
Pharmaceutics, 2023 Co-amorphous systems have been shown to be a promising strategy to address the poor water solubility of many drug candidates. However, little is known about the effect of downstream processing-induced stress on these systems.
Cecilie-Mathilde Sørensen +2 more
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Solid–Liquid Equilibrium in Co-Amorphous Systems: Experiment and Prediction [PDF]
Molecules, 2023 In this work, the solid–liquid equilibrium (SLE) of four binary systems combining two active pharmaceutical ingredients (APIs) capable of forming co-amorphous systems (CAMs) was investigated.
Alžběta Zemánková +3 more
doaj +6 more sources
Development of Co-Amorphous Systems for Inhalation Therapy—Part 2: In Silico Guided Co-Amorphous Rifampicin–Moxifloxacin and –Ethambutol Formulations [PDF]
PharmaceuticsBackground/Objectives: Tuberculosis (TB) remains a global health challenge due to long treatment durations, poor adherence, and growing drug resistance. Inhalable co-amorphous systems (COAMS) offer a promising strategy for targeted pulmonary delivery of ...
Eleonore Fröhlich +6 more
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Mechanistic Investigation into Crystallization of Hydrated Co-Amorphous Systems of Flurbiprofen and Lidocaine [PDF]
PharmaceuticsBackground: It is generally accepted that water as a plasticizer can decrease the glass transition temperatures (Tgs) of amorphous drugs and drug delivery systems, resulting in physical instabilities.
Xiaoyue Xu +4 more
doaj +7 more sources
Characterisation and stability of co-amorphous systems containing olanzapine and sulphonic acids [PDF]
Annals of Medicine, 2021 Introduction A large number of active pharmaceutical compounds currently under development are poorly water soluble, which can limit their bioavailability and results in formulation challenges [1].
Inês A. Santos +3 more
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Preparation of Co-Amorphous Systems by Freeze-Drying [PDF]
Pharmaceutics, 2020 Freeze-drying was evaluated as a production technique for co-amorphous systems of a poorly water-soluble drug. Naproxen was freeze-dried together with arginine and lysine as co-former.
Melvin Wostry +2 more
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Considerations on the Kinetic Processes in the Preparation of Ternary Co-Amorphous Systems by Milling [PDF]
Pharmaceutics, 2023 In non-strongly interacting co-amorphous systems, addition of a polymer, to further stabilize the co-amorphous systems, may influence the phase behavior between the components. In this study, the evolution of the composition of the amorphous phase in the
Yixuan Wang +2 more
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Destabilization of Indomethacin-Paracetamol Co-Amorphous Systems by Mechanical Stress [PDF]
Pharmaceutics, 2023 Using co-amorphous systems (CAMS) has shown promise in addressing the challenges associated with poorly water-soluble drugs. Quench-cooling is a commonly used CAMS preparation method, often followed by grinding or milling to achieve a fine powder that is
Rong Di, Thomas Rades, Holger Grohganz
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Data-Driven Prediction of the Formation of Co-Amorphous Systems [PDF]
Pharmaceutics, 2023 Co-amorphous systems (COAMS) have raised increasing interest in the pharmaceutical industry, since they combine the increased solubility and/or faster dissolution of amorphous forms with the stability of crystalline forms.
Elisabeth Fink +5 more
doaj +4 more sources
Two Drug–Drug Co-Amorphous Systems of Curcumin and Berberine Hydrochloride/Palmatine Hydrochloride with Improved Physicochemical Properties and Multifunctional Activities [PDF]
PharmaceuticsBackground/Objectives: The poor aqueous solubility of curcumin (CUR) limits its pharmaceutical application. Although amorphization can enhance its solubility, the amorphous form often exhibits insufficient physical stability.
Yanjie Zhang +5 more
doaj +3 more sources