The Use Of XRPD And ATR-FTIR In The Screening Of Three Component Co-amorphous Systems Created Via A Melt-Quench Method [PDF]
British Journal of Pharmacy, 2018 Multiple three-component co-amorphous systems have been created via a melt- quench method. This has been confirmed by a single glass transition in the individual DSC traces and then reinforced by X-ray diffraction data, which show an absence of ...
Benjamin Edgar +2 more
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Co-formability, solubility enhancement and stability of olanzapine co-amorphous systems produced with different co-formers [PDF]
Annals of Medicine, 2021 Introduction Strategies to address the problem of poorly water-soluble drugs encompass the conversion of a crystalline drug into an amorphous form to promote its apparent solubility and dissolution.
Ana C. Bastos +3 more
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Co-Amorphous Systems Based on Dihydroquercetin and l-Lysine: Synthesis and Evaluation. [PDF]
PharmaceuticsBackground/Objectives: Dihydroquercetin (DHQ), also known as taxifolin, is a natural flavonoid which has anti-inflammatory and wound-healing biological effects. One of the main limitations for developing formulations with DHQ is its low solubility in water at room temperature.
Svotin AA +12 more
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Assessing the Impact of Mesoporous, Co-Amorphous, and Polymer-Based Systems on Cefdinir’s Dissolution and Stability Via Predictive Modeling [PDF]
British Journal of Biomedical ScienceThe poor solubility and permeability of Biopharmaceutics Classification System (BCS) Class IV drugs pose major challenges to achieving sufficient oral bioavailability and therapeutic efficacy.
Raghad Al Nuss +2 more
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Impact of Preparation Method in Co-Amorphous System [PDF]
Sciences of Pharmacy, 2022 The co-amorphous solid dispersion system is one of the methods to improve the physicochemical characteristics and stability of a drug. With the appropriate material ratio and preparation method, a co-amorphous solid dispersion system can increase the bioavailability of the drug due to an increase in solubility. In addition, the co-amorphous system will
Amelia Soyata +3 more
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Preparation of Co-Amorphous Levofloxacin Systems for Pulmonary Application [PDF]
Pharmaceutics, 2023 Addressing antimicrobial resistance requires new approaches in various disciplines of pharmaceutical sciences. The fluoroquinolone levofloxacin (LEV) plays an important role in the therapy of lung infections.
Aljoscha Gabelmann +2 more
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Genistein Co-Amorphous Systems with Amino Acids: An Investigation into Enhanced Solubility and Biological Activity [PDF]
Pharmaceutics, 2023 Genistein, an isoflavone known for its antioxidant and antidiabetic effects, suffers from the drawback of low solubility. To overcome this limitation, co-amorphous systems were synthesized by incorporating amino acids that were chosen through ...
Ewa Garbiec +4 more
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Introduction to Pharmaceutical Co-amorphous Systems Using a Green Co-milling Technique. [PDF]
J Chem Educ, 2023 The concept of co-amorphous systems is introduced in an integrated laboratory experiment, designed for advanced chemistry students, using solvent-free, environmentally friendly mechanochemistry. The dual-drug naproxen-cimetidine co-amorphous system (NPX-CIM) is investigated as an example of the emergent field of medicinal mechanochemistry. Students are
Silva JFC +5 more
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Deaggregation and Crystallization Inhibition by Small Amount of Polymer Addition for a Co-Amorphous Curcumin-Magnolol System [PDF]
Pharmaceutics, 2021 Different from previously reported co-amorphous systems, a co-amorphous curcumin-magnolol (CUR-MAG CM) system, as compared with its crystalline counterparts, exhibited decreased dissolution due to its aggregation during dissolution.
Jiawei Han +6 more
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Recent advances in dual-drug co-amorphous systems
Drug Discovery Today, 2023 Poor solubility of drugs and therapeutic candidates poses a significant challenge in drug research and development. Biopharmaceutical class II drugs exhibit limited absorption because of their weak solubility and high permeability. Co-amorphous systems (CAMs) have been studied widely as a way to improve the solubility of drugs.
Rutuja Shelke +2 more
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