Compaction Behavior of Co-Amorphous Systems [PDF]
Pharmaceutics, 2023 Co-amorphous systems have been shown to be a promising strategy to address the poor water solubility of many drug candidates. However, little is known about the effect of downstream processing-induced stress on these systems.
Cecilie-Mathilde Sørensen +2 more
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Downstream Processing of Amorphous and Co-Amorphous Olanzapine Powder Blends [PDF]
Pharmaceutics, 2022 The work evaluates the stability of amorphous and co-amorphous olanzapine (OLZ) in tablets manufactured by direct compression. The flowability and the compressibility of amorphous and co-amorphous OLZ with saccharin (SAC) and the properties of the ...
Nuno F. da Costa +3 more
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Co-Amorphous Versus Deep Eutectic Solvents Formulations for Transdermal Administration [PDF]
Pharmaceutics, 2023 Transdermal administration can be considered as an interesting route to overcome the side-effects inherent to oral intake. Designing topical formulations with maximum drug efficiency requires the optimization of the permeation and the stability of the ...
Yannick Guinet +2 more
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Identification of Candesartan Cilexetil-L-Arginine Co-amorphous Formation and Its Solubility Test [PDF]
Borneo Journal of Pharmacy, 2022 The formation of co-amorphous is one alternative that can be attempted to enhance the solubility of drugs. The study aimed to identify the co-amorphous formation between candesartan cilexetil (CAN) and l-arginine (ARG) and to know its effect on the ...
Fikri Alatas +4 more
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Solubility and Physical Stability Enhancement of Loratadine by Preparation of Co-Amorphous Solid Dispersion with Chlorpheniramine and Polyvinylpyrrolidone [PDF]
Pharmaceutics, 2023 Loratadine (LRD), a non-sedating and slow-acting antihistamine, is often given in combination with short-onset chlorpheniramine maleate (CPM) to increase efficacy. However, LRD has poor water solubility resulting in low bioavailability.
Krit Suknuntha +3 more
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The Utilisation Of Thermal Methods For The Screening Of Three Component Co-amorphous Systems [PDF]
British Journal of Pharmacy, 2018 Indomethacin and piroxicam are known to become amorphous upon rapid cooling after melting. Multiple three-component co-amorphous mixtures have been produced via a melt quench method to evaluate the influence of the third component on stability and ...
Alessandra D'Angelo +2 more
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Mechanistic Investigation into Crystallization of Hydrated Co-Amorphous Systems of Flurbiprofen and Lidocaine [PDF]
PharmaceuticsBackground: It is generally accepted that water as a plasticizer can decrease the glass transition temperatures (Tgs) of amorphous drugs and drug delivery systems, resulting in physical instabilities.
Xiaoyue Xu +4 more
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Benchmarking the Solubility Enhancement and Storage Stability of Amorphous Drug–Polyelectrolyte Nanoplex against Co-Amorphous Formulation of the Same Drug [PDF]
Pharmaceutics, 2022 Amorphization, typically in the form of amorphous solid dispersion (ASD), represents a well-established solubility enhancement strategy for poorly soluble drugs.
Li Ming Lim, Jin-Won Park, Kunn Hadinoto
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Sustained Release of Co-Amorphous Matrine-Type Alkaloids and Resveratrol with Anti-COVID-19 Potential [PDF]
Pharmaceutics, 2022 Matrine (MAR), oxymatrine (OMAR), and sophoridine (SPD) are natural alkaloids with varying biological activities; matrine was recently used for the treatment of coronavirus disease 2019 (COVID-19).
Dandan Hu +5 more
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Formation of a Stable Co-Amorphous System for a Brick Dust Molecule by Utilizing Sodium Taurocholate with High Glass Transition Temperature [PDF]
Pharmaceutics, 2022 Brick dust molecules are usually poorly soluble in water and lipoidal components, making it difficult to formulate them in dosage forms that provide efficient pharmacological effects. A co-amorphous system is an effective strategy to resolve these issues.
Shohei Aikawa +4 more
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