Results 31 to 40 of about 96,622 (267)

Perpendicular magnetic anisotropy in Nd-Co alloy films nanostructured by di-block copolymer templates [PDF]

, 2012
Nd-Co amorphous magnetic films with perpendicular magnetic anisotropy have been grown on nanostructured templates prepared with self-organized di-block poly(styrene)-block-poly(4-vinylpyridine) copolymer layers with a periodic structure of 60 nm spaced ...
Alameda Maestro, José María, Anillo Abril, Adela, García Alonso, Francisco Javier, Martín Carbajo, José Ignacio, Morán Fernández, L., Navarro Palma, Elena, Rodríguez Rodríguez, Gabriel, Ruiz Valdepeñas, Luis, Valdés-Bango García, Fernando, Vicent López, José Luis, Vélez Fraga, María   +10 more
core   +8 more sources

Destabilization of Indomethacin-Paracetamol Co-Amorphous Systems by Mechanical Stress. [PDF]

Pharmaceutics, 2023
Using co-amorphous systems (CAMS) has shown promise in addressing the challenges associated with poorly water-soluble drugs. Quench-cooling is a commonly used CAMS preparation method, often followed by grinding or milling to achieve a fine powder that is suitable for subsequent characterization or further down-stream manufacturing.
Di R, Rades T, Grohganz H.
europepmc   +6 more sources

Predictive identification of co-formers in co-amorphous systems [PDF]

European Journal of Pharmaceutical Sciences, 2021
This work aims to understand the properties of co-formers that form co-amorphous pharmaceutical materials and to predict co-amorphous system formation. A partial least square - discriminant analysis (PLS-DA) was performed using known co-amorphous systems described by 36 variables based on the properties of the co-former and the binding energy of the ...
Luke I. Chambers, Holger Grohganz, Henrik Palmelund, Korbinian Löbmann, Thomas Rades, Osama M. Musa, Jonathan W. Steed   +6 more
openaire   +3 more sources

Physicochemical Characterization of a Co-Amorphous Atorvastatin-Irbesartan System with a Potential Application in Fixed-Dose Combination Therapy

Pharmaceutics, 2021
The aim of this study was to characterize a 1:1 molar ratio of a pharmacologically relevant co-amorphous atorvastatin-irbesartan (ATR-IRB) system obtained by quench cooling of the crystalline ATR/IRB physical mixture for potential use in the fixed-dose ...
Marcin Skotnicki, Barbara Jadach, Agnieszka Skotnicka, Bartłomiej Milanowski, Lidia Tajber, Marek Pyda, Jacek Kujawski   +6 more
doaj   +1 more source

Preparation of Co-Amorphous Systems by Freeze-Drying. [PDF]

Pharmaceutics, 2020
Freeze-drying was evaluated as a production technique for co-amorphous systems of a poorly water-soluble drug. Naproxen was freeze-dried together with arginine and lysine as co-former. To increase the solubility of naproxen in the starting solution, the applicability of five surfactants was investigated, namely sodium dodecyl sulfate, pluronic F-127 ...
Wostry M, Plappert H, Grohganz H.
europepmc   +7 more sources

Data-Driven Prediction of the Formation of Co-Amorphous Systems. [PDF]

Pharmaceutics, 2023
Co-amorphous systems (COAMS) have raised increasing interest in the pharmaceutical industry, since they combine the increased solubility and/or faster dissolution of amorphous forms with the stability of crystalline forms. However, the choice of the co-former is critical for the formation of a COAMS.
Fink E, Brunsteiner M, Mitsche S, Schröttner H, Paudel A, Zellnitz-Neugebauer S.   +5 more
europepmc   +4 more sources

Characterization, stability and solubility of co-amorphous systems of glibenclamide and L-arginine at different pH [PDF]

, 2022
Purpose: To investigate the stability and solubility of co-amorphous systems of glibenclamide (GBC) with L-arginine (L-Arg) at different pH values. Methods: Three co-amorphous solids of GBC and L-Arg were obtained by fast solvent evaporation using 2:1, 1:
Aragón-Aburto, Salma O, Domínguez-Chávez, Jorge G, Mondragón-Vásquez, Karina, Valerio- Alfaro, Gerardo   +3 more
core   +2 more sources

Combining Co-Amorphous-Based Spray Drying with Inert Carriers to Achieve Improved Bioavailability and Excellent Downstream Manufacturability

Pharmaceutics, 2020
It is crucial to improve poorly water-soluble orally administered drugs through both preclinical and therapeutic drug discovery. A co-amorphous formulation consisting of two low molecular weight (MW) molecules offers a solubility/dissolubility advantage ...
Yingxi Zhang, Yuan Gao, Xiaoxiao Du, Rou Guan, Zhonggui He, Hongzhuo Liu   +5 more
doaj   +1 more source

Development of Co-Amorphous Systems for Inhalation Therapy-Part 2: In Silico Guided Co-Amorphous Rifampicin-Moxifloxacin and -Ethambutol Formulations. [PDF]

Pharmaceutics
Background/Objectives: Tuberculosis (TB) remains a global health challenge due to long treatment durations, poor adherence, and growing drug resistance. Inhalable co-amorphous systems (COAMS) offer a promising strategy for targeted pulmonary delivery of fixed-dose combinations, improving efficacy and reducing systemic side effects.
Fröhlich E, Sharafeldin N, Reinisch V, Mohsenzada N, Mitsche S, Schröttner H, Zellnitz-Neugebauer S.   +6 more
europepmc   +2 more sources

Amorphous Thermal Spray Coating with Hard Materials Exhibiting Cleavage Fracture

Tribology Online, 2015
Hard materials were mixed with alloy powders and thermally sprayed at an ultra rapid cooling rate of more than 106°C/s. For example, 65Ni15Cr16P4B at% alloy powder containing tungsten carbide was thermally sprayed.
Toshiharu Morimoto, Yoshio Shin, Takashi Kumai, Jun Yanagimoto   +3 more
doaj   +1 more source