Preparation of Co-Amorphous Levofloxacin Systems for Pulmonary Application [PDF]
Pharmaceutics, 2023 Addressing antimicrobial resistance requires new approaches in various disciplines of pharmaceutical sciences. The fluoroquinolone levofloxacin (LEV) plays an important role in the therapy of lung infections.
Aljoscha Gabelmann +2 more
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Assessment of the stability of co-amorphous olanzapine in tablets [PDF]
Annals of Medicine, 2021 Introduction Amorphous and co-amorphous (CAM) materials have recently been used to improve oral bioavailability of drugs, by enhancing water solubility and dissolution rate from solid dosage forms [1,2].
Nuno F. da Costa +2 more
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The Use Of XRPD And ATR-FTIR In The Screening Of Three Component Co-amorphous Systems Created Via A Melt-Quench Method [PDF]
British Journal of Pharmacy, 2018 Multiple three-component co-amorphous systems have been created via a melt- quench method. This has been confirmed by a single glass transition in the individual DSC traces and then reinforced by X-ray diffraction data, which show an absence of ...
Benjamin Edgar +2 more
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Influence of Solvent Composition on the Performance of Spray-Dried Co-Amorphous Formulations [PDF]
Pharmaceutics, 2018 Ball-milling is usually used to prepare co-amorphous drug–amino acid (AA) mixtures. In this study, co-amorphous drug–AA mixtures were produced using spray-drying, a scalable industrially preferred preparation method. The influence of the solvent type and
Jaya Mishra +3 more
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Co-Amorphous Formation of Simvastatin-Ezetimibe: Enhanced Physical Stability, Bioavailability and Cholesterol-Lowering Effects in LDLr−/−Mice [PDF]
Pharmaceutics, 2022 Hypercholesterolemia is one of the independent risk factors for the development of cardiovascular diseases such as atherosclerosis. The treatment of hypercholesterolemia is of great significance to reduce clinical cardiovascular events and patient ...
Shamuha Bahetibieke +11 more
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Co-Amorphization of Kanamycin with Amino Acids Improves Aerosolization [PDF]
Pharmaceutics, 2020 Different formulation techniques have been investigated to prepare highly aerosolizable dry powders to deliver a high dose of antibiotics to the lung for treating local infections. In this study, we investigated the influence of the co-amorphization of a
Bishal Raj Adhikari +4 more
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A co-amorphous oleogelator of curcumin and piperine for olive oil as multifunctional food additives [PDF]
Current Research in Food ScienceThis study explores the development of a novel olive oil-based oleogel using a co-amorphous mixture of curcumin (Cur) and piperine (Pip) as the gelator. The co-amorphous mixture was prepared via a solvent co-evaporation method, optimizing the molar ratio
Shuang Tian +7 more
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Mechanism for Stabilizing an Amorphous Drug Using Amino Acids within Co-Amorphous Blends [PDF]
Pharmaceutics, 2023 Designing co-amorphous formulations is now recognized as a relevant strategy for improving the bioavailability of low-molecular-weight drugs. In order to determine the most suitable low-molecular-weight excipients for stabilizing the drug in the ...
Yannick Guinet +2 more
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Co-Amorphous Solid Dispersion System for Improvement in Dissolution Profile of N-(((1r,4r)-4-((6-fluorobenzo[d]oxazol-2-yl)amino)cyclohexyl)methyl)-2-methylpropane-2-sulfonamide as a Neuropeptide Y5 Receptor Antagonist [PDF]
PharmaceuticsBackground/Objectives: Brick dust molecules exhibit high melting points and ultralow solubility. Overcoming this solubility issue is challenging. Previously, we formulated a co-amorphous system for a neuropeptide Y5 receptor antagonist (NP) as a brick ...
Hironori Tanaka, Hiroshi Ueda
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Considerations on the Kinetic Processes in the Preparation of Ternary Co-Amorphous Systems by Milling [PDF]
Pharmaceutics, 2023 In non-strongly interacting co-amorphous systems, addition of a polymer, to further stabilize the co-amorphous systems, may influence the phase behavior between the components. In this study, the evolution of the composition of the amorphous phase in the
Yixuan Wang +2 more
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