Clozapine-carboxylic acid plasticized co-amorphous dispersions: Preparation, characterization and solution stability evaluation [PDF]
Acta Pharmaceutica, 2015 This study addressed the possibility of forming of co-amorphous systems between clozapine (CZ) and various carboxylic acid plasticizers (CAPs). The aim was to improve the solubility and oral bioavailability of clozapine.
Ali Ahmed Mahmoud Abdelhaleem +2 more
doaj +4 more sources
Preparation and Evaluation of Azithromycin as Rectal Suppository to Treat Bacterial Infection of COVID-19 [PDF]
Iraqi Journal of Pharmaceutical Sciences, 2023 In this study azithromycin was formulated for the first time as co-amorphous system suppository system to achieve the maximum bioavailability and to avoid the side effect that might be with oral route which is associated with this drug during treatment ...
Mena Raid Khalil +2 more
doaj +3 more sources
A drug-drug co-amorphous system for highly improved solubility of breviscapine: an experimental and computational study [PDF]
Scientific ReportsDrug-drug co-amorphous systems are a promising approach to improve the aqueous solubility of poorly water-soluble drugs. This study explores the combination of breviscapine (BRE) and matrine (MAT) form an amorphous salt, aiming to synergistically enhance
Zhi Dong +8 more
doaj +2 more sources
Development of Co-Amorphous Systems for Inhalation Therapy—Part 1: From Model Prediction to Clinical Success [PDF]
PharmaceuticsBackground/Objectives: The integration of machine learning (ML) and artificial intelligence (AI) has revolutionized the pharmaceutical industry by improving drug discovery, development and manufacturing processes.
Eleonore Fröhlich +5 more
doaj +2 more sources
Mechanistic Insight into the Enhanced Anti-Pulmonary Hypertension Efficacy of Wogonin Co-Amorphous [PDF]
PharmaceuticsBackground: Pulmonary hypertension (PH) remains a life-threatening rare disease characterized by inflammation and oxidative stress in pulmonary artery smooth muscle cells (PASMCs).
Zhongshui Xie +7 more
doaj +2 more sources
Deaggregation and Crystallization Inhibition by Small Amount of Polymer Addition for a Co-Amorphous Curcumin-Magnolol System [PDF]
Pharmaceutics, 2021 Different from previously reported co-amorphous systems, a co-amorphous curcumin-magnolol (CUR-MAG CM) system, as compared with its crystalline counterparts, exhibited decreased dissolution due to its aggregation during dissolution.
Jiawei Han +6 more
doaj +2 more sources
Co-Amorphous Andrographolide–Lysine with Unexpectedly Enhanced Solubility
CrystalsAndrographolide (ADG) is a typical poorly water-soluble drug, and a co-amorphous strategy was used here to improve its aqueous solubility. Co-amorphous systems of ADG and amino acids with a 1:1 molar ratio were screened via the neat ball milling method ...
Haifeng Luo +6 more
doaj +2 more sources
Wet granulation of co-amorphous indomethacin systems [PDF]
International Journal of Pharmaceutics, 2023 The feasibility of co-amorphous systems to be wet granulated together with microcrystalline cellulose (MCC) was investigated. Solid state and molecular interactions were analysed for various co-amorphous drug-amino acid formulations of indomethacin with tryptophan and arginine, respectively, via XRPD, DSC and FTIR.
David Schütz +2 more
openaire +3 more sources
Solid-Liquid Equilibrium in Co-Amorphous Systems: Experiment and Prediction. [PDF]
Molecules, 2023 In this work, the solid–liquid equilibrium (SLE) of four binary systems combining two active pharmaceutical ingredients (APIs) capable of forming co-amorphous systems (CAMs) was investigated. The binary systems studied were naproxen-indomethacin, naproxen-ibuprofen, naproxen-probucol, and indomethacin-paracetamol.
Zemánková A +3 more
europepmc +4 more sources
Cutting-Edge Approaches in the Co-Amorphization Process
PharmaceuticsBackground: Recently, the co-amorphization method has been widely used to refine the bioavailability characteristics of poorly soluble drugs in addition to overcoming the drawbacks of other traditional amorphization techniques.
Azza A. K. Mahmoud +2 more
doaj +2 more sources