Results 41 to 50 of about 96,622 (267)

Physio-chemical characterization of three-component co-amorphous systems generated by a melt-quench method [PDF]

, 2018
The purpose of this work was to evaluate the possibility of creating a ternary co-amorphous system and to determine how the properties of a co-amorphous material are altered by the addition of a selected third component.
A Górska, A. D’Angelo, A. P. Hurt, ACF Rumondor, ACF Rumondor, B Karolewicz, B. Edgar, BC Hancock, CMP Souza De, E Kaminska, E Yonemochi, F Qian, F Vrecer, K Edueng, K Löbmann, KA Graeser, KT Savjani, L Yu, LY Wang, M. D. Antonijević, MK Trivedi, MP Maheswaram, PR Dametto, R Laitinen, RB Chavan, S Yamamura, SJ Dengale, Y Guo, Y Sun, Y Yoshihashi   +29 more
core   +1 more source

A Novel Desloratadine-Benzoic Acid Co-Amorphous Solid: Preparation, Characterization, and Stability Evaluation

Pharmaceutics, 2018
Low physical stability is the limitation of the widespread use of amorphous drugs. The co-amorphous drug system is a new and emerging method for preparing a stable amorphous form.
Ahmad Ainurofiq, Rachmat Mauludin, Diky Mudhakir, Sundani Nurono Soewandhi   +3 more
doaj   +1 more source

Processing-Induced Disorder in Pharmaceutical Materials [PDF]

, 2016
This chapter focuses on the major types of pharmaceutical processing methods that have been widely reported to produce disordered material either intentionally or unintentionally.
Al-Obaidi, Alkhatib, Alonzo, Bahl, Balani, Breitenbach, Brough, Brown, Cal, Cerea, Chakraborty, Chattoraj, Chieng, Clark, Cordeiro, Cui, De Beer, Descamps, DiNunzio, Dinunzio, El-Badry, Elamin, Felton, Feng, Forster, Gazzaniga, Graeser, Guns, Gupta, He, Hu, Hu, Janssens, Kang, Karmwar, Ke, Keen, Khan, Kim, Koivisto, Lai, Laitinen, Laitinen, Lang, Lauer, Luisi, Luo, Löbmann, Löbmann, Nagy, Ng, Norrman, Otte, Otte, Passerini, Patterson, Porter, Qi, Qi, Qi, Qi, Repka, Riippi, Saerens, Sammoura, Santivarangkna, Sauer, Sauer, Sill, Sollohub, Tang, Trasi, Trasi, Van den Brande, Van Eerdenbrugh, Van Eerdenbrughand, Van Melkebeke, Vehring, Weatherley, Weuts, Willart, Willart, Willart, Williams, Windbergs, Windbergs, Wojnarowska, Yang, Zamani, Zema   +89 more
core   +1 more source

Recent Advances in Co-Former Screening and Formation Prediction of Multicomponent Solid Forms of Low Molecular Weight Drugs

Pharmaceutics, 2023
Multicomponent solid forms of low molecular weight drugs, such as co-crystals, salts, and co-amorphous systems, are a result of the combination of an active pharmaceutical ingredient (API) with a pharmaceutically acceptable co-former.
Yuehua Deng, Shiyuan Liu, Yanbin Jiang, Inês C. B. Martins, Thomas Rades   +4 more
doaj   +1 more source

Predicting Crystallization of Amorphous Drugs with Terahertz Spectroscopy. [PDF]

, 2015
There is a controversy about the extent to which the primary and secondary dielectric relaxations influence the crystallization of amorphous organic compounds below the glass transition temperature.
Löbmann, Korbinian, Rades, Thomas, Sibik, Juraj, Zeitler, J Axel   +3 more
core   +4 more sources

Glass Forming Ability, Thermal Stability, and Magnetic Properties of FeCoNiBSi Alloys with Different B Contents

Advances in Materials Science and Engineering, 2018
The dependence on the glass forming ability, magnetic property, and thermal stability of the (Fe0.39Co0.15Ni0.46)82−xB12+xSi6 (x = 0, 2, 4, and 6) alloys was investigated. The results show that the as-quenched alloy ribbons exhibit a completely amorphous
Haibo Sun, Yongfei Wang
doaj   +1 more source

Co-Amorphous Screening for the Solubility Enhancement of Poorly Water-Soluble Mirabegron and Investigation of Their Intermolecular Interactions and Dissolution Behaviors

Pharmaceutics, 2018
In the present study, the screening of Mirabegron (MBR) co-amorphous was performed to produce water-soluble and thermodynamically stable MBR co-amorphous with the purpose of overcoming the water solubility problem of MBR.
Ji-Hun An, Changjin Lim, Alice Nguvoko Kiyonga, In Hwa Chung, In Kyu Lee, Kilwoong Mo, Minho Park, Wonno Youn, Won Rak Choi, Young-Ger Suh, Kiwon Jung   +10 more
doaj   +1 more source

Co-Amorphous Drug Formulations in Numbers: Recent Advances in Co-Amorphous Drug Formulations with Focus on Co-Formability, Molar Ratio, Preparation Methods, Physical Stability, In Vitro and In Vivo Performance, and New Formulation Strategies

Pharmaceutics, 2021
Co-amorphous drug delivery systems (CAMS) are characterized by the combination of two or more (initially crystalline) low molecular weight components that form a homogeneous single-phase amorphous system.
Jingwen Liu, Holger Grohganz, Korbinian Löbmann, Thomas Rades, Nele-Johanna Hempel   +4 more
doaj   +1 more source

Improving Co-Amorphous Drug Formulations by the Addition of the Highly Water Soluble Amino Acid, Proline

Pharmaceutics, 2014
Co-amorphous drug amino acid mixtures were previously shown to be a promising approach to create physically stable amorphous systems with the improved dissolution properties of poorly water-soluble drugs.
Katrine Tarp Jensen, Korbinian Löbmann, Thomas Rades, Holger Grohganz   +3 more
doaj   +1 more source

Purification of Curcumin from Ternary Extract-Similar Mixtures of Curcuminoids in a Single Crystallization Step

, 2020
Crystallization-based separation of curcumin from ternary mixtures of curcuminoids having compositions comparable to commercial extracts was studied experimentally.
Horosanskaia, E., Lorenz, H., Seidel-Morgenstern, A., Yuan, L.   +3 more
core   +1 more source