Results 41 to 50 of about 267,333 (302)

Improving Co-Amorphous Drug Formulations by the Addition of the Highly Water Soluble Amino Acid, Proline

Pharmaceutics, 2014
Co-amorphous drug amino acid mixtures were previously shown to be a promising approach to create physically stable amorphous systems with the improved dissolution properties of poorly water-soluble drugs.
Katrine Tarp Jensen, Korbinian Löbmann, Thomas Rades, Holger Grohganz   +3 more
doaj   +1 more source

BX795-Organic Acid Coevaporates: Evaluation of Solid-State Characteristics, In Vitro Cytocompatibility and In Vitro Activity against HSV-1 and HSV-2

Pharmaceutics, 2021
BX795 is a TANK binding kinase-1 inhibitor that has shown excellent therapeutic activity in murine models of genital and ocular herpes infections on topical delivery.
Yogesh Sutar, Tejabhiram Yadavalli, Sagar Kumar Paul, Sudipta Mallick, Raghuram Koganti, Harsh Chauhan, Abhijit A. Date, Deepak Shukla   +7 more
doaj   +1 more source

Impact of Molecular Surface Diffusion on the Physical Stability of Co-Amorphous Systems [PDF]

Molecular Pharmaceutics, 2022
In this study, surface diffusion of l-aspartic acid-carvedilol (ASP-CAR) co-amorphous systems at different ASP concentrations is measured and correlated with their physical stability. ASP-CAR films at ASP concentrations of 1-5% (w/w) were prepared by a newly developed method based on a vacuum compression molding process.
Jingwen Liu, EnTe Hwu, Jacob Bannow, Holger Grohganz, Thomas Rades   +4 more
openaire   +4 more sources

Ternary Solid Dispersions: A Review of the Preparation, Characterization, Mechanism of Drug Release, and Physical Stability

Pharmaceutics, 2023
The prevalence of active pharmaceutical ingredients (APIs) with low water solubility has experienced a significant increase in recent years. These APIs present challenges in formulation, particularly for oral dosage forms, despite their considerable ...
Arif Budiman, Eli Lailasari, Neng Vera Nurani, Ellen Nathania Yunita, Gracia Anastasya, Rizqa Nurul Aulia, Ira Novianty Lestari, Laila Subra, Diah Lia Aulifa   +8 more
doaj   +1 more source

Recent Advances in Co-Former Screening and Formation Prediction of Multicomponent Solid Forms of Low Molecular Weight Drugs

Pharmaceutics, 2023
Multicomponent solid forms of low molecular weight drugs, such as co-crystals, salts, and co-amorphous systems, are a result of the combination of an active pharmaceutical ingredient (API) with a pharmaceutically acceptable co-former.
Yuehua Deng, Shiyuan Liu, Yanbin Jiang, Inês C. B. Martins, Thomas Rades   +4 more
doaj   +1 more source

Characterization of co-amorphous carvedilol–maleic acid system prepared by solvent evaporation

Pharmaceutical Development and Technology, 2023
The aim of this study was to enhance the solubility and stability of the water-insoluble drug carvedilol (CAR) with maleic acid (MLE) to create a co-amorphous system by a solvent evaporation method. Phase diagrams of co-amorphous CAR–MLE, constructed from peak height in the Fourier-transform infrared (FTIR) spectra and the glass transition temperature (
Takayuki Furuishi, Nanami Sato-Hata, Kaori Fukuzawa, Etsuo Yonemochi   +3 more
openaire   +2 more sources

Critical dynamics of ferromagnets [PDF]

, 1988
The crossover in the dynamics from isotropic to dipolar critical behaviour has been a matter of debate over many years. We review a mode coupling theory for dipolar ferromagnets which gives a unified explanation of the seemingly contradictory ...
Frey, Erwin, Schwabl, F.
core   +4 more sources

Properties of the Sodium Naproxen-Lactose-Tetrahydrate Co-Crystal upon Processing and Storage

Molecules, 2016
Co-crystals and co-amorphous systems are two strategies to improve the physical properties of an active pharmaceutical ingredient and, thus, have recently gained considerable interest both in academia and the pharmaceutical industry.
Ioana Sovago, Wenbo Wang, Danwen Qiu, Dhara Raijada, Jukka Rantanen, Holger Grohganz, Thomas Rades, Andrew D. Bond, Korbinian Löbmann   +8 more
doaj   +1 more source

An all-glass microfluidic network with integrated amorphous silicon photosensors for on-chip monitoring of enzymatic biochemical assay [PDF]

, 2017
A lab-on-chip system, integrating an all-glass microfluidics and on-chip optical detection, was developed and tested. The microfluidic network is etched in a glass substrate, which is then sealed with a glass cover by direct bonding.
Caputo, Domenico, Costantini, Francesca, de Cesare, Giampiero, Gardeniers, Han J. G. E., Manetti, Cesare, Nardecchia, Marco, Nascetti, Augusto, Salvio, Riccardo, Schlautmann, Stefan, Tiggelaar, Roald M.   +9 more
core   +15 more sources

A Comparative Study between A Protein Based Amorphous Formulation and Other Dissolution Rate Enhancing Approaches: A Case Study with Rifaximin

Pharmaceutics, 2022
Amorphous solid dispersions (ASDs) based on proteins as co-formers have previously shown promising potential to improve the solubility and bioavailability of poorly water-soluble drugs.
Xuezhi Zhuo, Maud Margrethe Brekstad Kjellin, Zarah Schaal, Tengyu Zhang, Korbinian Löbmann, Donglei Leng   +5 more
doaj   +1 more source