Results 31 to 40 of about 267,333 (302)
Predictive identification of co-formers in co-amorphous systems [PDF]
European Journal of Pharmaceutical Sciences, 2021 This work aims to understand the properties of co-formers that form co-amorphous pharmaceutical materials and to predict co-amorphous system formation. A partial least square - discriminant analysis (PLS-DA) was performed using known co-amorphous systems described by 36 variables based on the properties of the co-former and the binding energy of the ...
Luke I. Chambers +6 more
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Pharmaceutics, 2022 Matrine (MAR), oxymatrine (OMAR), and sophoridine (SPD) are natural alkaloids with varying biological activities; matrine was recently used for the treatment of coronavirus disease 2019 (COVID-19).
Dandan Hu +5 more
doaj +1 more source
Molecules, 2021 Converting crystalline compounds into co-amorphous systems is an effective way to improve the solubility of poorly water-soluble drugs. It is, however, of critical importance for the physical stability of co-amorphous systems to find the optimal mixing ...
Rong Di +3 more
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Thermal investigation on hydrated co-amorphous systems of nicotinamide and prilocaine [PDF]
European Journal of Pharmaceutics and Biopharmaceutics, 2023 It is generally recognized that water, acting as a plasticizer, increases molecular mobility, leading to a decrease of the glass transition temperature (Tg) in amorphous systems. However, an anti-plasticizing effect of water was recently observed on prilocaine (PRL).
Xu, Xiaoyue +2 more
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Assessment of the stability of co-amorphous olanzapine in tablets
Annals of Medicine, 2021 Introduction Amorphous and co-amorphous (CAM) materials have recently been used to improve oral bioavailability of drugs, by enhancing water solubility and dissolution rate from solid dosage forms [1,2].
Nuno F. da Costa +2 more
doaj +1 more source
The influence of moisture on the storage stability of co-amorphous systems [PDF]
International Journal of Pharmaceutics, 2021 Co-amorphization has been utilized to improve the physical stability of the respective neat amorphous drugs. However, physical stability of co-amorphous systems is mostly investigated under dry conditions, leaving the potential influence of moisture on storage stability unclear.
Liu, Jingwen +2 more
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Transition of amorphous to crystalline oxide film in initial oxide overgrowth on liquid metals [PDF]
, 2011 It is important to understand the mechanism of oxidation in the initial stage on the free surface of liquid metals. Mittemeijer and co-workers recently developed a thermodynamic model to study the oxide overgrowth on a solid metal surface.
Antonow GN +7 more
core +1 more source
Physio-chemical characterization of three-component co-amorphous systems generated by a melt-quench method [PDF]
, 2018 The purpose of this work was to evaluate the possibility of creating a ternary co-amorphous system and to determine how the properties of a co-amorphous material are altered by the addition of a selected third component.
A Górska +29 more
core +1 more source
Ultrathin Amorphous Silica Membrane Enhances Proton Transfer across Solid-to-Solid Interfaces of Stacked Metal Oxide Nanolayers while Blocking Oxygen [PDF]
, 2020 A large jump of proton transfer rates across solid-to-solid interfaces by inserting an ultrathin amorphous silica layer into stacked metal oxide nanolayers is discovered using electrochemical impedance spectroscopy and Fourier-transform infrared ...
Frei, H, Jo, WJ, Katsoukis, G
core +2 more sources
Pharmaceutics, 2018 The amorphous solid state offers an improved apparent solubility and dissolution rate. However, due to thermodynamic instability and recrystallization tendencies during processing, storage and dissolution, their potential application is limited. For this
Anna Karagianni +2 more
doaj +1 more source