Results 21 to 30 of about 267,333 (302)

Valsartan/2-Aminopyridine Co-Amorphous System: Preparation, Characterization, and Supramolecular Structure Simulation by Density Functional Theory Calculation [PDF]

Molecules
The objective of this work was to improve the solubility and discover a stable co-amorphous form of valsartan (VAL), a BCS class-II drug, by utilizing small molecule 2-Aminopyridine (2-AP) in varying molar ratios (2:1, 1:1, and 1:2), employing a solvent ...
Linjie Wang, Chunan Du, Yang Yang, Pengtu Zhang, Shiling Yuan   +4 more
doaj   +2 more sources

Molecular interactions of hydrated co-amorphous systems of prilocaine and lidocaine [PDF]

International Journal of Pharmaceutics
It is generally accepted that water as a plasticizer can decrease the glass transition temperatures (Tgs) of amorphous drugs and drug excipient systems. However, previous studies suggest that water, as an anti-plasticizer, can increase the Tgs of co-amorphous systems of prilocaine (PRL) and lidocaine (LID).
Xiaoyue Xu, Thomas Rades, Holger Grohganz   +2 more
openalex   +4 more sources

Physical Stability and Viscoelastic Properties of Co-Amorphous Ezetimibe/Simvastatin System [PDF]

Pharmaceuticals, 2019
The purpose of this paper is to examine the physical stability as well as viscoelastic properties of the binary amorphous ezetimibe–simvastatin system. According to our knowledge, this is the first time that such an amorphous composition is prepared and investigated.
Justyna Knapik-Kowalczuk, Krzysztof Chmiel, Karolina Jurkiewicz, Natália T. Correia, Wiesław Sawicki, Marian Paluch   +5 more
openalex   +9 more sources

Co-Amorphous System: A promising Strategy for Delivering Poorly Water - Soluble Drugs

Iraqi Journal of Pharmaceutical Sciences, 2020
Amorphization of drug has been considered as an attractive approach in improving drug solubility and bioavailability. Unlike their crystalline counterparts, amorphous materials lack the long-range order of molecular packing and present the highest energy
Eman S. Aldahhan, Ameera A. Radhi
doaj   +3 more sources

Pharmaceutical Co-Crystals, Salts, and Co-Amorphous Systems: A Novel Opportunity of Hot Melt Extrusion. [PDF]

J Drug Deliv Sci Technol, 2021
Narala S, Nyavanandi D, Srinivasan P, Mandati P, Bandari S, Repka MA.   +5 more
europepmc   +3 more sources

Bio-Purines as Co-Formers in Resveratrol Amorphous Systems [PDF]

Crystals
In the organic biomineralization of guanine (GUA), amorphous GUA is utilized to enhance its solubility, facilitating its transport for the formation of biominerals, and GUA nanocrystals are employed to protect tissues from ultraviolet damage.
Yuhang Liu, Ziqing Wu, Fenghua Chen, Yongming Liu, Rongrong Xue   +4 more
doaj   +2 more sources

Drug–drug co-amorphous systems: An emerging formulation strategy for poorly water-soluble drugs

Drug Discovery Today
Overcoming the poor water solubility of small-molecule drugs is a major challenge in the development of clinical pharmaceuticals. Amorphization of crystalline drugs is a highly effective strategy to improve their aqueous solubility. However, amorphous drugs are thermodynamically unstable and likely to crystallize during manufacturing and storage ...
Hongge Wang, Peixu Zhao, Ruilong Ma, Jirun Jia, Fu Qiang   +4 more
openalex   +3 more sources

Flow boiling-driven intensive growth of critical minerals during short-lived events [PDF]

Scientific Reports
Enrichment of critical metal tellurium (Te) in shallow crustal settings is often linked to hydrothermal boiling, yet the mechanisms driving Te-silica co-precipitation under dynamic fluid flow conditions remain unresolved.
Shen Gao, Atsushi Okamoto, Satoshi Matsuno, Edward L. Vinis, Otgonbayar Dandar, Xinyu Zou, Ross N. Mitchell, Jiajun Liu, Kezhang Qin, Hong Xu   +9 more
doaj   +2 more sources

Optimization and Characterization of Co-Amorphous System for Ideal Drug Candidate [PDF]

Dinkum Journal of Medical Innovations
Newly discovered and under discover drug substance/ APIs have the poor water solubility hence making it bioavailable is challenging. How co-amorphous system can address such problem. Active pharmaceutical ingredients, which require being absorbed into the bloodstream, maybe challenged by multiple barriers and harsh condition in the gastrointestinal ...
Roshan Gyawali, Yuvraj Regmi, Sachin Aryal, S. Rajarajan   +3 more
openalex   +2 more sources

Wet granulation of co-amorphous indomethacin systems [PDF]

International Journal of Pharmaceutics, 2023
The feasibility of co-amorphous systems to be wet granulated together with microcrystalline cellulose (MCC) was investigated. Solid state and molecular interactions were analysed for various co-amorphous drug-amino acid formulations of indomethacin with tryptophan and arginine, respectively, via XRPD, DSC and FTIR.
David Schütz, Annika Timmerhaus, Holger Grohganz   +2 more
openaire   +3 more sources