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Co-Amorphous Solid Dispersions for Solubility and Absorption Improvement of Drugs: Composition, Preparation, Characterization and Formulations for Oral Delivery

open access: yesPharmaceutics, 2018
The amorphous solid state offers an improved apparent solubility and dissolution rate. However, due to thermodynamic instability and recrystallization tendencies during processing, storage and dissolution, their potential application is limited. For this
Anna Karagianni   +2 more
doaj   +3 more sources

The interplay of dissolution, solution crystallization and solid-state transformation of amorphous indomethacin in aqueous solution

open access: yesInternational Journal of Pharmaceutics: X, 2020
Supersaturation profiles of amorphous indomethacin in aqueous solution containing 0.4 wt% and 4 wt% of isopropanol were predicted by combining separately-determined kinetics for dissolution, solution crystallization, and solid-state transformation.
Raj Schneider   +6 more
doaj   +1 more source

Co-Amorphous Screening for the Solubility Enhancement of Poorly Water-Soluble Mirabegron and Investigation of Their Intermolecular Interactions and Dissolution Behaviors

open access: yesPharmaceutics, 2018
In the present study, the screening of Mirabegron (MBR) co-amorphous was performed to produce water-soluble and thermodynamically stable MBR co-amorphous with the purpose of overcoming the water solubility problem of MBR.
Ji-Hun An   +10 more
doaj   +1 more source

Pore Accessibility in Amorphous Solid Water

open access: yesThe Astrophysical Journal, 2022
The porous nature of amorphous solid water (ASW) can significantly effect the chemical evolution of any planetary or astrophysical surface it forms on due to its ability to trap and retain volatiles. The amount of volatiles that can enter an ASW grain or
Rebecca A. Carmack   +2 more
doaj   +1 more source

Field Theory for Amorphous Solids [PDF]

open access: yesPhysical Review Letters, 2018
Glasses at low temperature fluctuate around their inherent states; glassy anomalies reflect the structure of these states. Recently there have been numerous observations of long-range stress correlations in glassy materials, from supercooled liquids to colloids and granular materials, but without a common explanation.
openaire   +3 more sources

Cellulose based polymers in development of amorphous solid dispersions

open access: yesAsian Journal of Pharmaceutical Sciences, 2019
Cellulose derivatives have gained immense popularity as stabilizers for amorphous solid dispersion owing to their diverse physicochemical properties. More than 20 amorphous solid dispersion-based products that have been approved for marketing consist of ...
Rahul B Chavan   +3 more
doaj   +1 more source

Pore evolution in interstellar ice analogues: simulating the effects of temperature increase [PDF]

open access: yes, 2014
Context. The level of porosity of interstellar ices - largely comprised of amorphous solid water (ASW) - contains clues on the trapping capacity of other volatile species and determines the surface accessibility that is needed for solid state reactions ...
Bossa, J. -B.   +3 more
core   +4 more sources

Precision Synthesis of Silicon Nanowires with Crystalline Core and Amorphous Shell [PDF]

open access: yes, 2013
A synthetic route to crystalline silicon (Si) nanowires with an amorphous Si shell is reported. Trisilane (Si3H8) and Sn(HMDS)(2) are decomposed in supercritical toluene at 450 degrees C.
Bogart, Timothy D.   +2 more
core   +1 more source

Compaction Behavior of Co-Amorphous Systems

open access: yesPharmaceutics, 2023
Co-amorphous systems have been shown to be a promising strategy to address the poor water solubility of many drug candidates. However, little is known about the effect of downstream processing-induced stress on these systems.
Cecilie-Mathilde Sørensen   +2 more
doaj   +1 more source

Intermolecular interaction and solid state characterization of abietic acid/chitosan solid dispersions possessing antimicrobial and antioxidant properties [PDF]

open access: yes, 2018
The aim of this work was to prepare and characterize solid dispersions of abietic acid (AB) and chitosan (CS) to investigate how formulation of the mixture may help in the battle against microbial colonization in different areas, such as the biomedical ...
Argent Richard, H.   +6 more
core   +1 more source

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