Results 31 to 40 of about 363,714 (297)

Preparation of Amorphous Solid Water [PDF]

Proceedings of the National Academy of Sciences, 1972
A method of preparation of solid amorphous water is reported, along with a demonstration of the absence of crystalline ice. The samples described are the first to be completely free of contamination with crystalline ice.
D S, Olander, S A, Rice
openaire   +2 more sources

The Structure of Liquid and Amorphous Hafnia. [PDF]

, 2017
Understanding the atomic structure of amorphous solids is important in predicting and tuning their macroscopic behavior. Here, we use a combination of high-energy X-ray diffraction, neutron diffraction, and molecular dynamics simulations to benchmark the
Benmore, Chris J, Gallington, Leighanne C, Ghadar, Yasaman, Low, John J, Navrotsky, Alexandra, Neuefeind, Joerg C, Skinner, Lawrie B, Stan, Marius, Ushakov, Sergey V, Vazquez-Mayagoitia, Alvaro, Weber, JK Richard   +10 more
core   +2 more sources

Orally Disintegrating Tablets Containing Melt Extruded Amorphous Solid Dispersion of Tacrolimus for Dissolution Enhancement

Pharmaceutics, 2018
In order to improve the aqueous solubility and dissolution of Tacrolimus (TAC), amorphous solid dispersions of TAC were prepared by hot melt extrusion with three hydrophilic polymers, Polyvinylpyrrolidone vinyl acetate (PVP VA64), Soluplus® and ...
Poovizhi Ponnammal, Parijat Kanaujia, Yin Yani, Wai Kiong Ng, Reginald B. H. Tan   +4 more
doaj   +1 more source

Processing Impact on In Vitro and In Vivo Performance of Solid Dispersions—A Comparison between Hot-Melt Extrusion and Spray Drying

Pharmaceutics, 2021
Presently, a large number of drug molecules in development are BCS class II or IV compounds with poor aqueous solubility. Various novel solubilization techniques have been used to enhance drug solubility.
Yongjun Li, Amanda K. P. Mann, Dan Zhang, Zhen Yang   +3 more
doaj   +1 more source

Excitations of amorphous solid helium

, 2012
We present neutron scattering measurements of the dynamic structure factor, $S(Q,\omega)$, of amorphous solid helium confined in 47 $\AA$ pore diameter MCM-41 at pressure 48.6 bar.
Bossy, Jacques, Glyde, Henry R., Ollivier, Jacques, Schober, Helmut   +3 more
core   +3 more sources

Yield stress in amorphous solids: A mode-coupling theory analysis [PDF]

, 2013
The yield stress is a defining feature of amorphous materials which is difficult to analyze theoretically, because it stems from the strongly non-linear response of an arrested solid to an applied deformation.
Berthier, Ludovic, Ikeda, Atsushi
core   +3 more sources

Co-Amorphous Solid Dispersion System for Improvement in Dissolution Profile of N-(((1r,4r)-4-((6-fluorobenzo[d]oxazol-2-yl)amino)cyclohexyl)methyl)-2-methylpropane-2-sulfonamide as a Neuropeptide Y5 Receptor Antagonist

Pharmaceutics
Background/Objectives: Brick dust molecules exhibit high melting points and ultralow solubility. Overcoming this solubility issue is challenging. Previously, we formulated a co-amorphous system for a neuropeptide Y5 receptor antagonist (NP) as a brick ...
Hironori Tanaka, Hiroshi Ueda
doaj   +1 more source

Composition and Technology Development for Obtaining Amorphous Solid Dispersion of Ebastine by Hot Melt Extrusion to Increase Dissolution Rate

Разработка и регистрация лекарственных средств, 2023
Introduction. Ebastine is a second-generation antihistamine drug available in the form of orally disintegrating tablets and film-coated tablets. Ebastine substance exhibits high bioavailability, but low solubility in water and gastrointestinal tract ...
K. A. Gusev, A. R. Aliev, Yu. E. Generalova, N. A. Aksenova, G. V. Rechkalov, D. N. Maimistov, G. M. Alekseeva, E. V. Flisyuk   +7 more
doaj   +1 more source

Goldstone-type fluctuations and their implications for the amorphous solid state

, 2004
In sufficiently high spatial dimensions, the formation of the amorphous (i.e. random) solid state of matter, e.g., upon sufficent crosslinking of a macromolecular fluid, involves particle localization and, concommitantly, the spontaneous breakdown of the
Annette Zippelius, D. J. Wallace, D. R. Nelson, H. E. Castillo, H. Kleinert, K. Broderix, L. D. Landau, Paul M. Goldbart, Swagatam Mukhopadhyay   +8 more
core   +1 more source

Transition of amorphous to crystalline oxide film in initial oxide overgrowth on liquid metals [PDF]

, 2011
It is important to understand the mechanism of oxidation in the initial stage on the free surface of liquid metals. Mittemeijer and co-workers recently developed a thermodynamic model to study the oxide overgrowth on a solid metal surface.
Antonow GN, Chase MW, H Men, Hoyer W, Merkwitz M, Shinohara K, Z Fan, Zouvelou N   +7 more
core   +1 more source