Results 271 to 280 of about 267,333 (302)

Insights into Co-Amorphous Systems in Therapeutic Drug Delivery

Therapeutic Delivery, 2021
Co-amorphous (CAM) systems are promising drug-delivery systems in the arena of therapeutic drug delivery, addressing the poor aqueous solubility of drugs by enhancing solubility and thereby improving the oral bioavailability and therapeutic effect of the drug.
Ridhima Singh, Vikram Joshi, Nitin Mehetre, Abhay T Sangamwar   +3 more
openaire   +2 more sources

Dipeptides as co-formers in co-amorphous systems

European Journal of Pharmaceutics and Biopharmaceutics, 2019
Drug-amino acid co-amorphous systems have become increasingly well-investigated systems to improve dissolution rate of poorly water-soluble drugs. In this study, dipeptides were investigated as co-formers for co-amorphous systems based on the hypothesis that dipeptides might combine the inherent properties of the two included amino acids.
Wu, Wenqi, Löbmann, Korbinian, Schnitzkewitz, Jan, Knuhtsen, Astrid, Pedersen, Daniel Sejer, Rades, Thomas, Grohganz, Holger   +6 more
openaire   +3 more sources

Aspartame as a co-former in co-amorphous systems

International Journal of Pharmaceutics, 2018
Co-amorphous drug delivery systems are a promising approach to improve the dissolution rate and therefore potentially the oral bioavailability of poorly-water soluble drugs. Several low molecular weight excipients, for instance amino acids, have previously been shown to stabilize the amorphous form and increase the dissolution rate of drugs.
Wenqi Wu, Korbinian Löbmann, Jan Schnitzkewitz, Astrid Knuhtsen, Daniel Sejer Pedersen, Holger Grohganz, Thomas Rades   +6 more
openaire   +3 more sources

Platensimycin-berberine chloride co-amorphous drug system: Sustained release and prolonged half-life

European Journal of Pharmaceutics and Biopharmaceutics, 2022
Co-amorphous technology is an emerging approach for pharmaceutical engineering of drugs and drug leads with improved physicochemical properties and bioavailability. Platensimycin (PTM) is a promising natural antibiotic lead that acts on bacterial fatty acid synthase and exhibits excellent antibacterial activity.
Zhe, Wang, Xin, Chen, Duanxiu, Li, Enhe, Bai, Hailu, Zhang, Yanwen, Duan, Yong, Huang   +6 more
openaire   +2 more sources

Development and characterization of a spray-dried inhalable ciprofloxacin-quercetin co-amorphous system

International Journal of Pharmaceutics, 2022
Spray drying is an increasingly used particle engineering technique for the production of dry powders for inhalation. However, the amorphous nature of most spray-dried particles remains a big challenge affecting both the chemical and the physical stability of the dried particles.
Nasser, Alhajj, Niall J, O'Reilly, Helen, Cathcart   +2 more
openaire   +2 more sources

Tranilast-matrine co-amorphous system: Strong intermolecular interactions, improved solubility, and physiochemical stability

International Journal of Pharmaceutics, 2023
There is a great interest to develop co-amorphous drug delivery systems to enhance the solubility of biopharmaceutics classification system (BCS) class II and IV drugs. However, most reported systems only resulted in severalfold solubility improvement. Tranilast (TRA) is an anti-allergic drug used to treat bronchial asthma and allergic rhinitis.
Dandan Hu, Xin Chen, Duanxiu Li, Hailu Zhang, Yanwen Duan, Yong Huang   +5 more
openaire   +2 more sources

Sulfonic Acid Derivatives in the Production of Stable Co-Amorphous Systems for Solubility Enhancement

Journal of Pharmaceutical Sciences, 2022
Co-amorphization is a promising approach to stabilize drugs in the amorphous form. Olanzapine, a poorly water-soluble drug was used in this study. Sulfonic acids (saccharin, cyclamic acid and acesulfame), free and in salt forms, were used as co-formers and compared with carboxylic acids commonly used in the preparation of co-amorphous systems.
Nuno F. da Costa, Inês A. Santos, Ana I. Fernandes, João F. Pinto   +3 more
openaire   +3 more sources

Organic acids as co-formers for co-amorphous systems – Influence of variation in molar ratio on the physicochemical properties of the co-amorphous systems

European Journal of Pharmaceutics and Biopharmaceutics, 2018
Co-amorphous drug delivery systems are attracting increasing attention in the pharmaceutical field, due to their promising potential to improve the solubility and bioavailability of poorly water-soluble drugs. In this study, three organic acids, namely benzoic acid, malic acid and citric acid, were investigated as co-formers for the weakly basic drug ...
Wu, Wenqi, Ueda, Hiroshi, Lobmann, Korbinian, Rades, Thomas, Grohganz, Holger   +4 more
openaire   +3 more sources

[The development of co-amorphous drug systems].

Yao xue xue bao = Acta pharmaceutica Sinica, 2016
Converting two poorly water-soluble crystalline drugs to co-amorphous drug systems by ball milling, quench-cooling, or cryo-milling method can improve stability of the drug, enhance dissolution rates, and reduce adverse reactions of the single drug. Co-amorphous system has been used to solve problems of co-administration of medicines.
Jing, Yao, Nian-Qiu, Shi, Xing-Lin, Wang
openaire   +1 more source

Influence of variation in molar ratio on co-amorphous drug-amino acid systems

European Journal of Pharmaceutics and Biopharmaceutics, 2016
Molecular interactions were investigated within four different co-amorphous drug-amino acid systems, namely indomethacin-tryptophan (Ind-Trp), furosemide-tryptophan (Fur-Trp), indomethacin-arginine (Ind-Arg) and furosemide-arginine (Fur-Arg). The co-amorphous systems were prepared by ball milling for 90min at different molar ratios and analyzed by XRPD
Katrine Tarp Jensen, Flemming Hofmann Larsen, Korbinian Löbmann, Thomas Rades, Holger Grohganz   +4 more
openaire   +3 more sources