Results 161 to 170 of about 9,897,717 (308)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Co-culture of bone marrow-derived macrophages with aged primary myoblasts. [PDF]

Biol Methods Protoc
Arsenault R, Ziadeh A, Green A, Dort J.
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Fibroblast-derived gremlin-1 Is associated with ovarian cancer-cell phenotypes in co-culture models. [PDF]

Front Oncol
Gao H, Xia M, Yu T, Chen X, Li X, Ruan H.   +5 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Chiffres-clés Statistiques de la Culture et de la Communication 2025 [PDF]

Les Chiffres clés, statistiques de la culture et de la communication répondent aux besoins d’information chiffrée des acteurs de la culture et constituent un outil essentiel pour penser les enjeux qui traversent le secteur.
Ministère de la Culture
core  

Co-Culture of Mammalian Cells and Photosynthetic Microorganisms for Oxygen Supply in Engineered Tissues. [PDF]

Cell Prolif
Wang M, Hala AF, van der Niet V, Bok ST, Özenler AK, Janssen M, Barbosa MJ, Martens D, Wijffels RH, Malda J, de Ruijter M.   +10 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The meanings of co-creation of culture

, 2015
Umeå as European Capital of Culture 2014 had co-creation as a guiding value and as a strategy for the year. While co-creation has become a widely used concept, it can be interpreted in different ways as it is translated in new contexts.
Näsholm, Malin,, Tomas, Blomquist,
core  

A multidimensional platform to support intestinal epithelial and immune cell co-culture. [PDF]

Front Nutr
Walker JL, Sprachman M, Welch M, Meehan-Qiu A, Kelly K, Shaughnessey E, Jenkins H, Iyer J, Cousens J, Engelke R, Hsi P, Christianson R, Wiellette E.   +12 more
europepmc   +1 more source