Results 61 to 70 of about 1,503,849 (360)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Optimizing the Structure and Optical Properties of Lanthanum Aluminate Perovskite through Nb⁵⁺ Doping

Nanomaterials
This work involves the introduction of niobium oxide into lanthanum aluminate (LaAlO3) via a conventional solid-state reaction technique to yield LaAlO3:Nb (LaNbxAl1−xO3+δ) samples with Nb5+ doping levels ranging from 0.00 to 0.25 mol%.
Wei Liu, Yang Zou, Yuang Chen, Zijian Lei, Lili Zhao, Lixin Song   +5 more
doaj   +1 more source

Inorganic Printed LEDs for Wearable Technology

Proceedings, 2020
: A new form of inorganic printed electronics has been developed that allows for high speed production of solid-state lighting on flexible substrates. Light emitting diodes (LED) become more efficient as their size is decreased. However, the difficulties
James Claypole, Alex Holder, Caitlin McCall, Amy Winters, William Ray, Tim Claypole   +5 more
doaj   +1 more source

Burnishing technique improves lubrication of threaded fasteners [PDF]

, 1965
Burnishing a molydisulfide coating into the thread surfaces of fasteners eliminates the need for binders and vehicles which ensure coverage and retention of the lubricant during fastening.
Gruper, J. L.
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Research on Bearing Fault Diagnosis Based on VMD-RCMWPE Feature Extraction and WOA-SVM-Optimized Multidataset Fusion

Sensors
Bearings are critical components whose failures in industrial machinery can lead to catastrophic breakdowns and costly downtime; yet, accurate early-stage diagnosis remains challenging due to the non-stationary, nonlinear nature of vibration signals and ...
Shouda Wang, Chenglong Wang, Youwei Lian, Bin Luo   +3 more
doaj   +1 more source

Coating and Pharmacokinetic Evaluation of Air Spray Coated Drug Coated Balloons [PDF]

Cardiovascular Engineering and Technology, 2018
Drug coated balloons (DCB) are becoming the standard-care treatment for peripheral arterial disease (PAD). DCB use excipients to transfer and retain anti-proliferative drugs, such as paclitaxel. Excipients thus play a vital role in the design and function of DCB, however methods to coat balloons with excipients and anti-proliferative drugs remain ...
Emily A. Turner, Marzieh K. Atigh, Megan M. Erwin, Uwe Christians, Saami K. Yazdani   +4 more
openaire   +2 more sources

Mixed polyvalent-monovalent metal coating for carbon-graphite fibers [PDF]

, 1982
An improved coating of gasification catalyst for carbon-graphite fibers is provided comprising a mixture of a polyvalent metal such as calcium and a monovalent metal such as lithium.
Harper-Tervet, J., Humphrey, M. F., Tervet, F. W.   +2 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source