Results 61 to 70 of about 1,175,481 (311)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Optimizing the Structure and Optical Properties of Lanthanum Aluminate Perovskite through Nb⁵⁺ Doping

Nanomaterials
This work involves the introduction of niobium oxide into lanthanum aluminate (LaAlO3) via a conventional solid-state reaction technique to yield LaAlO3:Nb (LaNbxAl1−xO3+δ) samples with Nb5+ doping levels ranging from 0.00 to 0.25 mol%.
Wei Liu, Yang Zou, Yuang Chen, Zijian Lei, Lili Zhao, Lixin Song   +5 more
doaj   +1 more source

Inorganic Printed LEDs for Wearable Technology

Proceedings, 2020
: A new form of inorganic printed electronics has been developed that allows for high speed production of solid-state lighting on flexible substrates. Light emitting diodes (LED) become more efficient as their size is decreased. However, the difficulties
James Claypole, Alex Holder, Caitlin McCall, Amy Winters, William Ray, Tim Claypole   +5 more
doaj   +1 more source

Tunable Double Negative Band Structure from Non-Magnetic Coated Rods

, 2010
A system of periodic poly-disperse coated nano-rods is considered. Both the coated nano-rods and host material are non-magnetic. The exterior nano-coating has a frequency dependent dielectric constant and the rod has a high dielectric constant.
Bouchitté G, Bouchitté G Bourel C, Bouchitté G Schweizer B, Fortes S P Lipton R P Shipman S P, Fortes S P Lipton R P Shipman S P, Jelinek L, Milton G W, O'Brien S, Pendry J, Robert Lipton, Schulgasser K, Yue Chen, Zhikov V V, Zhikov V V   +13 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Research on Bearing Fault Diagnosis Based on VMD-RCMWPE Feature Extraction and WOA-SVM-Optimized Multidataset Fusion

Sensors
Bearings are critical components whose failures in industrial machinery can lead to catastrophic breakdowns and costly downtime; yet, accurate early-stage diagnosis remains challenging due to the non-stationary, nonlinear nature of vibration signals and ...
Shouda Wang, Chenglong Wang, Youwei Lian, Bin Luo   +3 more
doaj   +1 more source

Coating and Pharmacokinetic Evaluation of Air Spray Coated Drug Coated Balloons [PDF]

Cardiovascular Engineering and Technology, 2018
Drug coated balloons (DCB) are becoming the standard-care treatment for peripheral arterial disease (PAD). DCB use excipients to transfer and retain anti-proliferative drugs, such as paclitaxel. Excipients thus play a vital role in the design and function of DCB, however methods to coat balloons with excipients and anti-proliferative drugs remain ...
Emily A. Turner, Marzieh K. Atigh, Megan M. Erwin, Uwe Christians, Saami K. Yazdani   +4 more
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Broadband optical radiation detector [PDF]

, 1981
A method and apparatus for detecting optical radiation by optically monitoring temperature changes in a microvolume caused by absorption of the optical radiation to be detected is described.
Gupta, A., Hong, S. D., Moacanin, J.
core   +1 more source

Application of hydrophobic fluorinated silicon oxide nanoparticle coating on electrodynamic screen (EDS) films for enhancing self-cleaning function of solar collectors [PDF]

, 2020
Optical surfaces, which are exposed to outdoor environmental conditions, are susceptible to dust deposition. Sunlight incident on the surface of photovoltaic (PV) modules is attenuated by the dust layer accumulation on the front surface of the modules ...
Guo, Yuchun
core