Results 51 to 60 of about 106,004 (265)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Mechanistic investigation on the influence of coating weights on the corrosion behaviour of hot-dip-galvanised Zn-Mg-Al coatings

npj Materials Degradation
Time-lapse Microscopy, scanning vibrating electrode technique and potentiodynamic methods were used to study the influence of increasing coating weight (80–310 gm–2) on microstructure, cut-edge and surface corrosion of Zn-Mg-Al coatings in 0.17 M NaCl ...
A. D. Malla, J. H. Sullivan, D. J. Penney, M. Goldsworthy, D. Britton, G. Williams, F. Goodwin, A. P. Cardoso   +7 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Fabrication of Flexible PVA/Polyaniline/WS2 Composite Film and Its High Capacitance Behaviors

International Journal of Electrochemical Science, 2020
A flexible ternary composite film based on polyvinyl alcohol (PVA), polyaniline (PANI) and WS2 was prepared via the electropolymerization of the prefabricated PVA/aniline/WS2 hydrogel. As-prepared PVA/PANI/WS2 composite film was characterized by scanning
Aiqin Liang, Danhua Zhu, Liming Xu, Weiqiang Zhou, Jingkun Xu, Xuemin Duan   +5 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Microstructure, mechanical properties and corrosion behavior of high-entropy (WZrNbTaM)C (M= Cr, Ni, Ti) carbides

Journal of Materials Research and Technology
In this work, the high-entropy stability is predicted based on density functional theory (DFT) firstly. Then, the (WZrNbTaM)C (M = Cr, Ni, Ti) high-entropy carbide powders are synthesized by carbothermal reduction reaction.
Jiatai Zhang, Weili Wang, Zhixuan Zhang, Sijie Wei, Qiang Zhang, Zongyao Zhang, Weibin Zhang   +6 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Recent advances in harnessing biolubricants to enhance tribological performance and environmental responsibility – Bibliometric review (2015–2024)

Cleaner Engineering and Technology
The necessity of conducting research on biolubricants arises from the urgent need to develop sustainable alternatives to conventional petroleum-based lubricants, which contribute to environmental degradation and carbon emissions.
Agus Nugroho, Muhammad Kozin, Zhang Bo, Rizalman Mamat, Mohd Fairusham Ghazali, Muhammad Prisla Kamil, Prabowo Puranto, Diah Ayu Fitriani, Siti Amalina Azahra, Kusuma Putri Suwondo, Putri Sayyida Ashfiya   +10 more
doaj   +1 more source