Results 21 to 30 of about 11,177 (226)

Review of cobalamin status and disorders of cobalamin metabolism in dogs

Journal of Veterinary Internal Medicine, 2020
Disorders of cobalamin (vitamin B12) metabolism are increasingly recognized in small animal medicine and have a variety of causes ranging from chronic gastrointestinal disease to hereditary defects in cobalamin metabolism.
Stefanie Kather, Niels Grützner, Peter H. Kook, Franziska Dengler, Romy M. Heilmann   +4 more
doaj   +1 more source

A randomised controlled trial investigating the effect of vitamin B12 supplementation on neurological function in healthy older people: the Older People and Enhanced Neurological function (OPEN) study protocol [ISRCTN54195799]. [PDF]

, 2011
BACKGROUND: Vitamin B12 deficiency is common in older people and the prevalence increases with age. Vitamin B12 deficiency may present as macrocytic anaemia, subacute combined degeneration of the spinal cord, or as neuropathy, but is often asymptomatic ...
Allen, Elizabeth, Kerry Mills, Whyte, K, Fletcher, Astrid E, Elbourne, Diana, Richards, Marcus, Ken Whyte, Mills, Kerry, Robert Clarke, Richards, M, Letley, Louise, Dangour, Alan D, Elbourne, D, Mills, K, Ricardo Uauy, Whyte, Ken, Louise Letley, Dangour, AD, Fletcher, AE, Diana Elbourne, Fasey, Nicky, Uauy, Ricardo, Alan D Dangour, Uauy, R, Astrid E Fletcher, Marcus Richards, Clarke, Robert, Clarke, R, Nicky Fasey, Elizabeth Allen, Fasey, N, Allen, E, Letley, L   +32 more
core   +1 more source

A single-center cross-sectional study on the clinical profile of pancytopenia and a novel scoring system for megaloblastic anemia

Apollo Medicine, 2022
Background: Our study tries to identify the main culprits causing pancytopenia and its typical clinical presentation, along with the clinical and hematological profile of megaloblastic anemia (MGA)-induced pancytopenia, in a tertiary care hospital in ...
Sanjaykumar Somsingbhai Rathwa, Darshankumar Manubhai Raval, Shashwat Mallik, Shahin Khan   +3 more
doaj   +1 more source

Gene identification for the cblD defect of vitamin B12 metabolism [PDF]

, 2008
Background Vitamin B12 (cobalamin) is an essential cofactor in several metabolic pathways. Intracellular conversion of cobalamin to its two coenzymes, adenosylcobalamin in mitochondria and methylcobalamin in the cytoplasm, is necessary for the ...
Rosenblatt, David S., Lerner-Ellis, Jordan P, Stucki, Martin, Suormala, T, Baumgartner, Matthias R; https://orcid.org/, Baumgartner, Matthias R., Fowler, Brian, Lerner-Ellis, Jordan P., Newbold, R F, Newbold, Robert F, Coelho, D, Fowler, B, Lerner-Ellis, J P, Newbold, Robert F., Rosenblatt, D S, Coelho, David, Suormala, Terttu, Rosenblatt, David S, Stucki, M, Baumgartner, M R   +19 more
core   +1 more source

The Biochemical Basis of Cobalamin Deficiency [PDF]

Mayo Clinic Proceedings, 1994
In this report, our goal was to summarize the current knowledge of the biochemical basis for the impaired DNA synthesis and neuropathy associated with vitamin B12 deficiency.We reviewed the pertinent literature and our clinical experience with cobalamin deficiency.Studies have established that the megaloblastic hematopoiesis associated with vitamin B12
A, Tefferi, R K, Pruthi
openaire   +2 more sources

Vitamin B-12 deficiency stimulates osteoclastogenesis via increased homocysteine and methylmalonic acid [PDF]

, 2009
The risk of nutrient deficiencies increases with age in our modern Western society, and vitamin B(12) deficiency is especially prevalent in the elderly and causes increased homocysteine (Hcy) and methylmalonic acid (MMA) levels.
Bravenboer, N., Vaes, Bart L T, Vaes, B.L.T., Everts, V., Wilma T. Steegenga, Bravenboer, Nathalie, Steegenga, W.T., Lute, Carolien, Carolien Lute, de Groot, L.C.P.G.M., Müller, M.R., Henk J. Blom, de Groot, C.P.G.M., Muller, M., Dhonukshe-Rutten, R.A.M., de Groot, Lisette C P G M, Dhonukshe-Rutten, R.A., Bart L. T. Vaes, Teun J. de Vries, Blom, Henk J, Nathalie Bravenboer, Groot, L.C.P.G.M. de, de Vries, Teun J, Müller, Michael, Everts, Vincent, Rosalie A. Dhonukshe-Rutten, Michael Müller, de Vries, T.J., Lisette C. P. G. M. de Groot, Dhonukshe-Rutten, Rosalie A, Steegenga, Wilma T, Groot, C.P.G.M., de, Lute, C., Vries, T. J., Blom, H.J., Everts, V, Vries, T.J., de, Vincent Everts   +37 more
core   +1 more source

Dietary deficiency of cobalamin presented solely as schizoaffective disorder in a lacto-vegetarian adolescent

Indian Journal of Psychological Medicine, 2015
Cobalamin is an important nutrient. It is not synthesized in human body and supplied only in nonvegetarian diet. Its deficiency reported with range of psychiatric disorders. Only four pediatric cases have been reported as psychiatric disorders.
Somashekarappa Dhananjaya, Narayana Manjunatha, Rajashekaaiah Manjunatha, Seetharamarao Udaya Kumar   +3 more
doaj   +1 more source

Cobalamin Deficiency Can Mask Depleted Body Iron Reserves [PDF]

, 2015
Vitamin B12 deficiency impairs DNA synthesis and causes erythroblast apoptosis, resulting in anaemia from ineffective erythropoiesis. Iron and cobalamin deficiency are found together in patients for various reasons.
Solmaz, Soner, Ozdogu, Hakan, Boga, Can
core   +1 more source

Vitamin B12 – a scoping review for Nordic Nutrition Recommendations 2023

Food & Nutrition Research, 2023
Vitamin B12 (cobalamin) is essential for normal metabolic function, and even moderate deficiency of this vitamin has negative health effects. Vitamin B12 is found in animal foods, and as vegetarian diets are increasingly popular in Western countries, one
Anne-Lise Bjørke-Monsen, Vegard Lysne
doaj   +1 more source

A dodecylamine derivative of cyanocobalamin potently inhibits the activities of cobalamin-dependent methylmalonyl-CoA mutase and methionine synthase of Caenorhabditis elegans

FEBS Open Bio, 2014
In this study, we showed that cyanocobalamin dodecylamine, a ribose 5′-carbamate derivative of cyanocobalamin, was absorbed and accumulated to significant levels by Caenorhabditis elegans and was not further metabolized.
Tomohiro Bito, Yukinori Yabuta, Tsuyoshi Ichiyanagi, Tsuyoshi Kawano, Fumio Watanabe   +4 more
doaj   +1 more source