Results 31 to 40 of about 435,892 (214)

Cobalamin and folate status in women during early pregnancy in Bhaktapur, Nepal

Journal of Nutritional Science, 2021
The demand for cobalamin (vitamin B12) and folate is increased during pregnancy, and deficiency during pregnancy may lead to complications and adverse outcomes. Yet, the status of these micronutrients is unknown in many populations.
Catherine Schwinger, Shakun Sharma, Ram K. Chandyo, Mari Hysing, Ingrid Kvestad, Manjeswori Ulak, Suman Ranjitkar, Merina Shrestha, Laxman P. Shrestha, Adrian McCann, Per M. Ueland, Tor A. Strand   +11 more
doaj   +1 more source

Neurological disorders in vitamin B12 deficiency [PDF]

Терапевтический архив, 2019
The review discusses thesteps of vitamin B12 metabolism and its role in maintaining of neurological functions. The term "vitamin B12 (cobalamin)" refers to several substances (cobalamins) of a very similar structure. Cobalamin enters the body with animal
Ch S Pavlov, I V Damulin, Yu O Shulpekova, E A Andreev   +3 more
doaj   +1 more source

Review of cobalamin status and disorders of cobalamin metabolism in dogs

Journal of Veterinary Internal Medicine, 2020
Disorders of cobalamin (vitamin B12) metabolism are increasingly recognized in small animal medicine and have a variety of causes ranging from chronic gastrointestinal disease to hereditary defects in cobalamin metabolism.
Stefanie Kather, Niels Grützner, Peter H. Kook, Franziska Dengler, Romy M. Heilmann   +4 more
doaj   +1 more source

A single-center cross-sectional study on the clinical profile of pancytopenia and a novel scoring system for megaloblastic anemia

Apollo Medicine, 2022
Background: Our study tries to identify the main culprits causing pancytopenia and its typical clinical presentation, along with the clinical and hematological profile of megaloblastic anemia (MGA)-induced pancytopenia, in a tertiary care hospital in ...
Sanjaykumar Somsingbhai Rathwa, Darshankumar Manubhai Raval, Shashwat Mallik, Shahin Khan   +3 more
doaj   +1 more source

The Biochemical Basis of Cobalamin Deficiency [PDF]

Mayo Clinic Proceedings, 1994
In this report, our goal was to summarize the current knowledge of the biochemical basis for the impaired DNA synthesis and neuropathy associated with vitamin B12 deficiency.We reviewed the pertinent literature and our clinical experience with cobalamin deficiency.Studies have established that the megaloblastic hematopoiesis associated with vitamin B12
A, Tefferi, R K, Pruthi
openaire   +2 more sources

Dietary deficiency of cobalamin presented solely as schizoaffective disorder in a lacto-vegetarian adolescent

Indian Journal of Psychological Medicine, 2015
Cobalamin is an important nutrient. It is not synthesized in human body and supplied only in nonvegetarian diet. Its deficiency reported with range of psychiatric disorders. Only four pediatric cases have been reported as psychiatric disorders.
Somashekarappa Dhananjaya, Narayana Manjunatha, Rajashekaaiah Manjunatha, Seetharamarao Udaya Kumar   +3 more
doaj   +1 more source

Vitamin B12 deficiency in an infant secondary to nutritional deficiency and an inadequate maternal diet. [PDF]

JPGN Rep
ABSTRACT Vitamin B12 (cobalamin, Cbl) is an essential micronutrient for DNA synthesis and neurological development. Its deficiency in infants, although infrequent in developed countries, can cause megaloblastic anemia, psychomotor delay, and neurological damage that may become irreversible if not treated early.
Sala-Lluch S, Mesas-Vila N, Ferrando-Monleón S, Barrés-Fernández A, Villar-Vera C, Arcos-Machancoses JV.   +5 more
europepmc   +2 more sources

A randomised controlled trial investigating the effect of vitamin B12 supplementation on neurological function in healthy older people: the Older People and Enhanced Neurological function (OPEN) study protocol [ISRCTN54195799]. [PDF]

, 2011
BACKGROUND: Vitamin B12 deficiency is common in older people and the prevalence increases with age. Vitamin B12 deficiency may present as macrocytic anaemia, subacute combined degeneration of the spinal cord, or as neuropathy, but is often asymptomatic ...
Allen, Elizabeth, Kerry Mills, Whyte, K, Fletcher, Astrid E, Elbourne, Diana, Richards, Marcus, Ken Whyte, Mills, Kerry, Robert Clarke, Richards, M, Letley, Louise, Dangour, Alan D, Elbourne, D, Mills, K, Ricardo Uauy, Whyte, Ken, Louise Letley, Dangour, AD, Fletcher, AE, Diana Elbourne, Fasey, Nicky, Uauy, Ricardo, Alan D Dangour, Uauy, R, Astrid E Fletcher, Marcus Richards, Clarke, Robert, Clarke, R, Nicky Fasey, Elizabeth Allen, Fasey, N, Allen, E, Letley, L   +32 more
core   +2 more sources

Nonnative Thiol and Aniline Methylation, Including Enantioselective Dithiol Desymmetrization, by Multicomponent Cobamide‐Dependent Methyltransferases Using Unactivated Methyl Donors

Angewandte Chemie, EarlyView.
Mixed MtaABC/MtgABC methyltransferase systems were developed for non‐native thiol and aniline methylation using the unactivated methyl donors methanol and glycine betaine. The platform enabled site‐selective and enantioselective methylation with turnover number up to 6000, representing the first enantioselective non‐native catalysis by cobamide ...
Amardeep Kumar, Osman Ishag Adam, Paras Gupta, Jared C. Lewis   +3 more
wiley   +2 more sources

Substrate‐Dependent Crosslinking by the Cytochrome P450 From Aminopyruvatide Biosynthesis

Angewandte Chemie, EarlyView.
Substitutions in the aminopyruvatide precursor peptide altered the C─C linkage formed from a YLY motif by the P450 ApyO to a N─C linkage in a WLY motif. Moreover, constitutional isomers crosslinked by C─C and C─O linkages were formed from YYY or YWY motifs. ABSTRACT Cytochrome P450s catalyze an array of reactions including crosslinking of aromatic side
Chandrashekhar Padhi, Dinh T. Nguyen, Lingyang Zhu, Lide Cha, Jesse W. Wald, Douglas A. Mitchell, Wilfred A. van der Donk   +6 more
wiley   +2 more sources