The GSK3 signaling pathway is activated by cocaine and is critical for cocaine conditioned reward in mice. [PDF]
PLoS ONE, 2014 The Akt - GSK3 signaling pathway has been recently implicated in psychostimulant-induced behavioral and cellular effects. Here, the ability of cocaine to regulate the activity of Akt and GSK3 was investigated by measuring the phosphorylation states of ...
Jonathan S Miller +5 more
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Environmental enrichment facilitates cocaine-cue extinction, deters reacquisition of cocaine self-administration and alters AMPAR GluA1 expression and phosphorylation [PDF]
, 2015 This study investigated the combination of environmental enrichment (EE) with cocaine‐cue extinction training on reacquisition of cocaine self‐administration.
Dhonnchadha, Brid Aine Nic +5 more
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Adolescent D-amphetamine treatment in a rodent model of ADHD: pro-cognitive effects during adolescence and cocaine abuse risk during adulthood [PDF]
, 2015 Attention-deficit/hyperactivity disorder (ADHD) is comorbid with cocaine abuse. Whereas initiating ADHD medication in childhood does not alter later cocaine abuse risk, initiating medication during adolescence may increase risk.
Baskin, Britahny M. +5 more
core +1 more source
Corticosterone Potentiation of Cocaine-Induced Reinstatement of Conditioned Place Preference in Mice is Mediated by Blockade of the Organic Cation Transporter 3 [PDF]
, 2016 The mechanisms by which stressful life events increase the risk of relapse in recovering cocaine addicts are not well understood. We previously reported that stress, via elevated corticosterone, potentiates cocaine-primed reinstatement of cocaine seeking
A Amphoux +51 more
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Masters of Healing: Cocaine and the Ideal of the Victorian Medical Man [PDF]
, 2016 This article offers a new perspective on the relationship between cocaine and medical practitioners in late-nineteenth and early-twentieth century Britain.
Small, Douglas
core +1 more source
Orexin-Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine [PDF]
, 2015 Release of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced cocaine-seeking behavior.
Aguinaga, David +17 more
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Frontiers in Behavioral Neuroscience, 2022 A high percentage of relapse to compulsive cocaine-taking and cocaine-seeking behaviors following abstinence constitutes a major obstacle to the clinical treatment of cocaine addiction.
Changliang Zhu +19 more
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Can ropinirole modulate reinforcing subjective effects of cocaine in humans?
Frontiers in Psychiatry, 2011 In this study we evaluated, by means of the Cocaine Rush Visual Analogue Scale (CRVAS), the impact of ropinirole on the expected rush induced by cocaine in a group of heroin addicts abusing cocaine; the self-reported reaction to the rush blockade (if ...
Angelo Giovanni Icro eMaremmani +8 more
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Cocaine serves as a peripheral interoceptive conditioned stimulus for central glutamate and dopamine release. [PDF]
PLoS ONE, 2008 Intravenous injections of cocaine HCl are habit-forming because, among their many actions, they elevate extracellular dopamine levels in the terminal fields of the mesocorticolimbic dopamine system. This action, thought to be very important for cocaine's
Roy A Wise, Bin Wang, Zhi-Bing You
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CB1 Receptor Antagonism Blocks Stress-Potentiated Reinstatement of Cocaine Seeking in Rats [PDF]
, 2015 Rationale Under some conditions, stress, rather than directly triggering cocaine seeking, potentiates reinstatement to other stimuli, including a subthreshold cocaine dose.
Baker, David A. +6 more
core +2 more sources