Results 1 to 10 of about 307,196 (303)

Synaptic Zn2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior

Translational Psychiatry, 2021
Cocaine binds to the dopamine (DA) transporter (DAT) to regulate cocaine reward and seeking behavior. Zinc (Zn2+) also binds to the DAT, but the in vivo relevance of this interaction is unknown.
Juan L. Gomez, Jordi Bonaventura, Jacqueline Keighron, Kelsey M. Wright, Dondre L. Marable, Lionel A. Rodriguez, Sherry Lam, Meghan L. Carlton, Randall J. Ellis, Chloe J. Jordan, Guo-hua Bi, Oscar Solis, Marco Pignatelli, Michael J. Bannon, Zheng-Xiong Xi, Gianluigi Tanda, Michael Michaelides   +16 more
doaj   +1 more source

The cocaine compulsion zone theory explains the reinstatement of lever pressing behavior in rats in response to a single cocaine dose

Heliyon, 2023
A single non-contingent dose of cocaine reinstates extinguished lever pressing behavior in rats trained to self-administer cocaine. This represents a model of relapse in cocaine use disorder and the number of lever presses has been the standard measure ...
Dakota B. Zinani, Jhanvi N. Desai, Andrew B. Norman   +2 more
doaj   +1 more source

mGluR5 knockout mice exhibit normal conditioned place-preference to cocaine [PDF]

, 2011
Metabotropic glutamate receptor 5 (mGluR5) null mutant (-/-) mice have been reported to totally lack the reinforcing or locomotor stimulating effects of cocaine.
Andrew L. Varnell, Donald C. Cooper, Melissa A. Fowler   +2 more
core   +2 more sources

Adolescent D-amphetamine treatment in a rodent model of ADHD: pro-cognitive effects during adolescence and cocaine abuse risk during adulthood [PDF]

, 2015
Attention-deficit/hyperactivity disorder (ADHD) is comorbid with cocaine abuse. Whereas initiating ADHD medication in childhood does not alter later cocaine abuse risk, initiating medication during adolescence may increase risk.
Baskin, Britahny M., Dwoskin, Linda P., Jeon, Sae-Mi, Jordan, Chloe J., Kantak, Kathleen M., Taylor, Danielle M.   +5 more
core   +1 more source

Cocaine vaccine dAd5GNE protects against moderate daily and high-dose "binge" cocaine use.

PLoS ONE, 2020
The cocaine vaccine dAd5GNE is comprised of a disrupted serotype 5 adenovirus gene therapy vector covalently conjugated to the cocaine analog GNE. The vaccine evokes a high titer of circulating anti-cocaine antibodies that prevent cocaine from reaching ...
David F Havlicek, Jonathan B Rosenberg, Bishnu P De, Martin J Hicks, Dolan Sondhi, Stephen M Kaminsky, Ronald G Crystal   +6 more
doaj   +1 more source

mGlu5 inhibition in the basolateral amygdala prevents estrous cycle-dependent changes in cue-induced cocaine seeking

Addiction Neuroscience, 2023
Drug associated cues are a common relapse trigger for individuals recovering from cocaine use disorder. Sex and ovarian hormones influence patterns of cocaine use and relapse vulnerability, with studies indicating that females show increased cue-induced ...
Claire M. Corbett, Emily N.D. Miller, Jessica A. Loweth   +2 more
doaj   +1 more source

mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]

, 2018
Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua, Gardner, Eliot L, He, Yi, Jordan, Chloe J, Li, Jie, Li, Xia, Peng, Xiao-Qing, Xi, Zheng-Xiong, Yang, Hong-Ju, Zhang, Hai-Ying   +9 more
core   +2 more sources

Corticosterone Potentiation of Cocaine-Induced Reinstatement of Conditioned Place Preference in Mice is Mediated by Blockade of the Organic Cation Transporter 3 [PDF]

, 2016
The mechanisms by which stressful life events increase the risk of relapse in recovering cocaine addicts are not well understood. We previously reported that stress, via elevated corticosterone, potentiates cocaine-primed reinstatement of cocaine seeking
A Amphoux, A Schmitt, Analisa Taylor, BA Nic Dhonnchadha, Beliz Kurtoglu, Brittany Nino, D Gründemann, D Gründemann, D Gründemann, DA Baker, David A Baker, DM Platt, E Schomig, EN Graf, F Martel, G Horvath, H Duan, HW Shen, Jayme R McReynolds, JJ Burmeister, JL Malisch, John R Mantsch, JR Mantsch, JR McReynolds, K Engel, LC Daws, LL Iversen, M Aliczki, M Cui, N Baganz, NL Baganz, O Vranjkovic, Oliver Vranjkovic, Olivia Derricks, Paul J Gasser, PJ Fletcher, PJ Gasser, PJ Gasser, R Sinha, R Sinha, R Zwart, Robert A Wheeler, S Erb, S Gong, SZ Langer, T Lenz, T Shang, Terra Ambrosius, V Gorboulev, V Vialou, V Vialou, XY Zhang   +51 more
core   +2 more sources

Prenatal cocaine exposure uncouples mGluR1 from Homer1 and Gq Proteins. [PDF]

PLoS ONE, 2014
Cocaine exposure during gestation causes protracted neurobehavioral changes consistent with a compromised glutamatergic system. Although cocaine profoundly disrupts glutamatergic neurotransmission and in utero cocaine exposure negatively affects ...
Kalindi Bakshi, Raminder Parihar, Satindra K Goswami, Melissa Walsh, Eitan Friedman, Hoau-Yan Wang   +5 more
doaj   +1 more source

Environmental enrichment facilitates cocaine-cue extinction, deters reacquisition of cocaine self-administration and alters AMPAR GluA1 expression and phosphorylation [PDF]

, 2015
This study investigated the combination of environmental enrichment (EE) with cocaine‐cue extinction training on reacquisition of cocaine self‐administration.
Dhonnchadha, Brid Aine Nic, Gauthier, Jamie M., Kantak, Kathleen M., Lin, Amy, Man, Heng-Ye, Spealman, Roger D.   +5 more
core   +1 more source