Results 111 to 120 of about 11,001,215 (252)

People experiencing homelessness and their experiences with substance use services for alcohol treatment in England: Journey mapping based on semi‐structured interviews

Addiction, EarlyView.
Abstract Background and aims Alcohol consumption at high levels is common among people experiencing homelessness and contributes to inequalities. In relative terms these individuals are underrepresented in substance use services. This study captured common trajectories and identified barriers and facilitators to accessing treatment among a group of ...
Vera Helen Buss, Jamie Brown, Melissa Oldham, Sarah E. Jackson, Lion Shahab, Dimitra Kale, Sharon Cox   +6 more
wiley   +1 more source

Prescribed pharmaceutical alternatives initiative coinciding with reductions in unregulated street opioid use among young people who use drugs: An interrupted time series analysis

Addiction, EarlyView.
Abstract Background and aims In British Columbia, Canada, an initiative was implemented in 2020 to reduce overdose mortality by prescribing pharmaceutical opioids (primarily hydromorphone) as a substitute for the toxic unregulated drug supply. This study estimated changes in the level and trend of unregulated opioid use and non‐prescribed hydromorphone
Erica McAdam, Mohammad Karamouzian, Michael John Milloy, Carmen Verdicchio, Eric C. Sayre, Kanna Hayashi, Thomas Kerr, Kora DeBeck   +7 more
wiley   +1 more source

Sex-based differences in multidimensional clinical assessments of early-abstinence crack cocaine users.

PLoS ONE, 2019
Crack cocaine use disorder (CUD) has been related to sex differences. This work aimed to compare the severity of drug use and the severity of other negative related outcomes in males and females with CUD.
Breno Sanvicente-Vieira, Diego Luiz Rovaris, Felipe Ornell, Anne Sordi, Leonardo Melo Rothmann, João Paulo Ottolia Niederauer, Jaqueline Bohrer Schuch, Lisia von Diemen, Felix Henrique Paim Kessler, Rodrigo Grassi-Oliveira   +9 more
doaj   +1 more source

The calcium antagonist PN 200-110 inhibits the reinforcing properties of cocaine

, 1991
The effect of a dihydropyridine (DHP) calcium antagonist, PN 200-110, on cocaine reinforcing properties was investigated using conditioned place preference paradigm.
GESSA GL, PANI L, MARTELLOTTA MC, FRATTA, WALTER, KUZMIN A, A. and Martellotta, M. C. and Gessa, G. L. and Fratta, Pani, L. and Kuzmin   +9 more
core   +1 more source

From allostasis to addiction: Cortisol dysregulation, daily stress and relations with 9‐year alcohol and substance use disorder severity in community adults

Addiction, EarlyView.
Abstract Background and aims Diurnal cortisol dysregulation and daily stressor severity may jointly forecast long‐term alcohol use disorder (AUD) and substance use disorder (SUD) severity, yet most evidence is cross‐sectional and relies on single cortisol indices.
Nur Hani Zainal, Natalia Van Doren
wiley   +1 more source

Prescribed alternative stimulants among people who use unregulated stimulants: Examining the association between maximum dose reached and medication discontinuation in the first 3 years of implementation in British Columbia, Canada

Addiction, EarlyView.
Abstract Background and aims In 2020, British Columbia (BC), Canada, introduced ‘Prescribed Alternatives’ (PA) as an approach to offering regulated substances to people accessing the unregulated supply. This study aimed to estimate and compare prescribing characteristics of dextroamphetamine and methylphenidate stimulant PAs in BC, to estimate ...
Bin Zhao, Kevin Hu, Roshni Desai, Shania Au, Kali‐olt Sedgemore, Vitor Tardelli, Addie Carter, Paxton Bach, Christian Schutz, Amanda Slaunwhite, Alexis Crabtree, Heather Palis   +11 more
wiley   +1 more source

Substance abuse treatment and psychiatric comorbidity: do benefits spill over? analysis of data from a prospective trial among cocaine-dependent homeless persons

Substance Abuse Treatment, Prevention, and Policy, 2006
Background Comorbid psychiatric illness can undermine outcomes among homeless persons undergoing addiction treatment, and psychiatric specialty care is not always readily available.
Kertesz Stefan G, Madan Alok, Wallace Dennis, Schumacher Joseph E, Milby Jesse B   +4 more
doaj   +1 more source

Clinicians' and people who use drugs' perspectives on artificial intelligence in addiction medicine

Addiction, EarlyView.
Abstract Background and aims Artificial intelligence (AI) may improve addiction medicine workflows and health outcomes but raises questions about data privacy and unintended harms for people who use drugs (PWUD). This qualitative study aimed to understand the perspectives of clinicians and PWUD regarding perceived benefits and concerns about clinical ...
Patrick J. A. Kelly, Elizabeth Chen, Amelia Bailey, Katie Biello, Brandon D. L. Marshall, Josiah D. Rich, Jaclyn M. W. Hughto   +6 more
wiley   +1 more source

Insights from the Twittersphere: a cross-sectional study of public perceptions, usage patterns, and geographical differences of tweets discussing cocaine

Frontiers in Psychiatry
IntroductionCocaine abuse represents a major public health concern. The social perception of cocaine has been changing over the decades, a phenomenon closely tied to its patterns of use and abuse.
Consuelo Castillo-Toledo, Consuelo Castillo-Toledo, Oscar Fraile-Martínez, Oscar Fraile-Martínez, Carolina Donat-Vargas, Carolina Donat-Vargas, F. J. Lara-Abelenda, F. J. Lara-Abelenda, Miguel Angel Ortega, Miguel Angel Ortega, Cielo Garcia-Montero, Cielo Garcia-Montero, Fernando Mora, Fernando Mora, Melchor Alvarez-Mon, Melchor Alvarez-Mon, Melchor Alvarez-Mon, Javier Quintero, Javier Quintero, Miguel Angel Alvarez-Mon, Miguel Angel Alvarez-Mon, Miguel Angel Alvarez-Mon   +21 more
doaj   +1 more source

Prefrontal cortical BDNF: A regulatory key in cocaine- and food-reinforced behaviors

Neurobiology of Disease, 2016
Brain-derived neurotrophic factor (BDNF) affects synaptic plasticity and neural structure and plays key roles in learning and memory processes. Recent evidence also points to important, yet complex, roles for BDNF in rodent models of cocaine abuse and ...
Elizabeth G. Pitts, Jane R. Taylor, Shannon L. Gourley   +2 more
doaj   +1 more source