Results 121 to 130 of about 11,001,215 (252)
Substance‐free and substance‐related reinforcement in relation to substance use: A meta‐analysis
Addiction, EarlyView.Abstract Background and aims Contemporary behavioral economic theory conceptualizes addiction as an operant reinforcer pathology in which substance use is substantively influenced by reinforcement obtained through substance‐free sources. The aim of the current meta‐analysis was to quantitatively synthesize cross‐sectional associations between both ...
Brian M. Bird +5 more
wiley +1 more source
Association Between Parental Cocaine Use and Sudden Infant Death Syndrome: A Systematic Review
HU RevistaIntroduction: Sudden infant death syndrome (SIDS) is defined as the unexpected death of an infant under one year of age with no clear cause, typically occurring during sleep, and associated with various environmental risk factors.
Sofia Holetz de Toledo Lourenço +3 more
doaj
A discrete subpopulation of PFC-LHb neurons govern cocaine place preference
Translational PsychiatryAddiction is a complex behavioral disorder characterized by compulsive drug-seeking and drug use despite harmful consequences. The prefrontal cortex (PFC) plays a crucial role in cocaine addiction, involving decision-making, impulse control, memory, and ...
Nur Abdel-Hay +2 more
doaj +1 more source
Post-Retrieval Extinction Attenuates Cocaine Memories
, 2014 Recent studies have shown that post-retrieval extinction training attenuates fear and reward-related memories in both humans and rodents. This noninvasive, behavioral approach has the potential to be used in clinical settings to treat maladaptive ...
Aston-Jones, Gary +3 more
core +1 more source
Addiction, EarlyView.Abstract Background and aims Heavy drug use has been associated with small‐scale drug crime, but the substance use histories of individuals involved in the manufacturing, smuggling and wholesaling of larger quantities of drugs [here referred to as serious drug crimes (SDC)] have been largely unexamined.
Julie Elizabeth Brummer +3 more
wiley +1 more source
ECM remodeling in the mPFC exacerbates cocaine-induced hyperactivity and impairs threat vigilance
Translational PsychiatryThe extracellular matrix (ECM) plays a crucial role in addiction-related neuroplasticity. While chondroitinase ABC (chABC)-mediated ECM degradation has been shown to impair drug-conditioned place preference, its effects on cocaine-induced locomotor ...
Xiaorui Lin +11 more
doaj +1 more source
CellsThe United States is currently facing a drug overdose epidemic. The nucleus accumbens core (NAcore), a brain region critical for reward and aversion behaviors, undergoes structural and functional synaptic adaptations in response to chronic drug exposure.
Juan Pablo Taborda-Bejarano +4 more
doaj +1 more source
Cocaine-mediated downregulation of microglial miR-124 expression involves promoter DNA methylation
, 2017 Neuroinflammation plays a critical role in the development of reward-related behavior in cocaine self-administration rodents. Cocaine, one of most commonly abused drugs, has been shown to activate microglia both in vitro and in vivo.
Fang Niu (316587) +6 more
core +1 more source
Addiction, EarlyView.Abstract Background and aims Creating and tracking quality measures has improved outcomes in many areas of healthcare; however, quality measures specific to opioid treatment programs (OTPs) have not yet been developed. Based on the success seen in other fields, introducing quality measures in OTPs should help enhance positive outcomes and decrease ...
Barrett Wallace Montgomery +7 more
wiley +1 more source
, 2019 The lack of effective treatments and a high rate of relapse in cocaine addiction constitute a major health problem. The present study was conducted to examine the expression of tryptophan-derived metabolites in the context of cocaine addiction and ...
Campos-Cloute, Rafael +18 more
core +1 more source