Results 61 to 70 of about 265,487 (267)

Homeopathy on the integrative care of cocaine-related disorders (Cocacrack-3 Study): Updated Protocol for a randomized, placebo-controlled, double-blind, crossover clinical trial

International Journal of High Dilution Research - ISSN 1982-6206
Background: Effective pharmacotherapy for Cocaine Use Disorder is needed. The Cocacrack-2 study showed that homeopathic fifty-millesimal potencies of Opium and Erythroxylum coca were more effective than a placebo in reducing cocaine/crack use. However, the study experienced high dropout rates, which are common in the study population but could ...
Ubiratan Cardinalli Adler, Karen Berenice Denez, Maria Ligia dos Reis Bellaguarda, Lia Lira Olivier Sanders, Eugênio de Moura Campos, Matheus de Matos Dourado Simões, Tainá Rocha Josino, Marcos Alan Sousa Barbosa, Heloisa São Thiago da Costa Pereira, Rinaldo Ferreira, Erlandson Uchôa Lacerda, Elaine Cristina Coelho Baptista, Javier Salvador Gamarra Junior, Maristela Schiabel Adler, Edson Zangiacomi Martinez   +14 more
openaire   +1 more source

Genètica i drogues psicoestimulants: dependència de cocaïna i consum d’èxtasi [PDF]

, 2011
[cat] La cocaïna i l’èxtasi (MDMA, 3,4-metilendioximetamfetamina) són drogues psicoestimulants que incrementen l’activitat del sistema nerviós central i perifèric amb efectes com l’augment de l’estat d’alerta, la resistència, la productivitat, la ...
Fernàndez Castillo, Noèlia
core  

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Adolescent circadian rhythm disruption increases reward and risk-taking

Frontiers in Neuroscience
IntroductionCircadian rhythm disturbances have long been associated with the development of psychiatric disorders, including mood and substance use disorders.
Lauren M. DePoy, Lauren M. DePoy, Chelsea A. Vadnie, Chelsea A. Vadnie, Chelsea A. Vadnie, Kaitlyn A. Petersen, Kaitlyn A. Petersen, Madeline R. Scott, Madeline R. Scott, Wei Zong, RuoFei Yin, Ross C. Matthaei, Fernanda Juarez Anaya, Callie I. Kampe, George C. Tseng, Colleen A. McClung, Colleen A. McClung, Colleen A. McClung   +17 more
doaj   +1 more source

Delay and probability discounting of sexual and monetary outcomes in individuals with cocaine use disorders and matched controls.

PLoS ONE, 2015
Individuals with cocaine use disorders are disproportionately affected by HIV/AIDS, partly due to higher rates of unprotected sex. Recent research suggests delay discounting of condom use is a factor in sexual HIV risk.
Matthew W Johnson, Patrick S Johnson, Evan S Herrmann, Mary M Sweeney   +3 more
doaj   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Catholic Values and Gender Politics in the Colombian Mass Media: Acción Cultural Popular (ACPO) in the 1970s

Gender &History, EarlyView.
ABSTRACT The 1970s were a decade of huge change for women in Colombia, from the legalisation of divorce to increased access to education, labour market participation and contraception. This article examines how the Catholic non‐governmental organisation Acción Cultural Popular (Popular Cultural Action, ACPO) responded to women's changing roles and ...
Anna Cant
wiley   +1 more source

Immunosuppressant treatment reduces cocaine-induced behavioral sensitization in mice

Frontiers in Pharmacology
BackgroundNeuroinflammation plays fundamental, though still not fully understood, roles in the pathophysiology of substance use disorders, including cocaine addiction. Chronic cocaine exposure promotes neuroinflammatory signaling and synaptic alterations
Gabriella Luciana de Oliveira, Maria Carolina Machado da Silva, Giovanni Freitas Gomes, Roberta dos Santos Ribeiro, Gabriela Reis Cussat, Rúbia Aparecida Fernandes, Jorge Lucas Nascimento Souza, Heliana de Barros Fernandes, Aline Silva de Miranda, Victor Rodrigues Santos, Lílian Lacerda Bueno, Luciene Bruno Vieira, Fabrício Araújo Moreira, Antônio Carlos Pinheiro de Oliveira   +13 more
doaj   +1 more source

Uma abordagem farmacogenética para o estudo de reações de defesa e dependência de drogas em ratos [PDF]

, 2006
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciênicas Biológicas.
Vendruscolo, Leandro Franco
core  

Cocaine use disorders and serum magnesium profile

, 2009
INTRODUCTION: Magnesium influences the nervous system via its actions on the release and metabolism of neurotransmitters, and abnormal magnesium metabolism has been implicated in several neuropsychiatric disorders with prominent mood symptoms. The aim
Tonioni, Federico, Rinaldi, Federica, Bria, Pietro, Tedeschi, Daniela, Martinotti, Giovanni, Barra, Andrea, Autullo, Gianna, Janiri, Luigi, Martinelli, David   +8 more
core   +1 more source