Results 31 to 40 of about 40,355 (156)
Frontiers in Neuroscience, 2022 Studies using either continuous or intermittent access cocaine self-administration procedures showed that cocaine seeking increases during abstinence (incubation of cocaine craving), and that this effect is higher after intermittent cocaine access. Other
Celine Nicolas +3 more
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"EFFECT OF APAMIN ON TOLERANCE TO COCAINE-INDUCED LOCOMOTOR ACTIVITY IN MICE" [PDF]
Acta Medica Iranica, 2004 In the present study, the effect of apamin (potassium channel blocker) on tolerance to cocaine-induced locomotor activity in mice has been investigated.
H. R. Jamshidi +1 more
doaj +1 more source
Brain Stimulation, 2022 Background: Cocaine addiction is a major public health problem. Despite decades of intense research, no effective treatments are available. Both preclinical and clinical studies strongly suggest that deep brain stimulation of the nucleus accumbens (NAcc)
Marsida Kallupi +6 more
doaj
Silent Cocaine Poisoning [PDF]
Asia Pacific Journal of Medical Toxicology, 2014 Background: Cocaine poisoning is known for causing severe clinical effects such as tachycardia, hypertension, agitation and confusion. Absence of clinical manifestations in cocaine poisoning is unusual.
Rachid El-Jaoudi +5 more
doaj
Scientific Reports, 2023 Cocaine is a widely abused, hepatotoxic drug without an FDA-approved pharmacotherapy specific for cocaine addiction or overdose. It is recognized as a promising therapeutic strategy to accelerate cocaine metabolism which can convert cocaine to ...
Linyue Shang +5 more
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FREIDA: A Framework for developing quantitative agent based models based on qualitative expert knowledge: an example of organised crime [PDF]
arXiv, 2023 Developing ABMs of organized crime networks supports law enforcement strategies but is often limited by scarce quantitative data. This challenge extends to other psychosocial contexts like mental health and social systems. While qualitative data from reports and interviews is more accessible, current ABM methodologies struggle to integrate both data ...
arxiv
Heliyon, 2023 A single non-contingent dose of cocaine reinstates extinguished lever pressing behavior in rats trained to self-administer cocaine. This represents a model of relapse in cocaine use disorder and the number of lever presses has been the standard measure ...
Dakota B. Zinani +2 more
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Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion. [PDF]
PLoS ONE, 2012 Mice and rats were tested for reduced sensitivity to cocaine-induced hyper-locomotion after pretreatment with anti-cocaine antibody or cocaine hydrolase (CocH) derived from human butyrylcholinesterase (BChE). In Balb/c mice, direct i.p. injection of CocH
Marilyn E Carroll +9 more
doaj +1 more source
Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes.
PLoS ONE, 2013 ObjectiveThe search for genetic vulnerability factors in cocaine dependence has focused on the role that neuroplasticity plays in addiction. However, like many other drugs, the ability of an individual to metabolize cocaine can also influence ...
André Brooking Negrão +6 more
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