Results 31 to 40 of about 307,196 (303)
Journal of Chemical Neuroanatomy, 2017 Cocaine is a naturally occurring and illicitly used psychostimulant drug. Cocaine acts at monoaminergic neurotransmitter transporters to block uptake of the monoamines, dopamine, serotonin and norepinephrine. The resulting increase of monoamines in the extracellular space underlies the positively reinforcing effects that cocaine users seek.
Oliver, Kudlacek +9 more
openaire +3 more sources
Initial d2 dopamine receptor sensitivity predicts cocaine sensitivity and reward in rats. [PDF]
PLoS ONE, 2013 The activation of dopamine receptors within the mesolimbic dopamine system is known to be involved in the initiation and maintenance of cocaine use. Expression of the D2 dopamine receptor subtype has been implicated as both a predisposing factor and ...
Kathryn E Merritt, Ryan K Bachtell
doaj +1 more source
Cocaine serves as a peripheral interoceptive conditioned stimulus for central glutamate and dopamine release. [PDF]
PLoS ONE, 2008 Intravenous injections of cocaine HCl are habit-forming because, among their many actions, they elevate extracellular dopamine levels in the terminal fields of the mesocorticolimbic dopamine system. This action, thought to be very important for cocaine's
Roy A Wise, Bin Wang, Zhi-Bing You
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Associations amongst form of cocaine used (powder vs crack vs both) and HIV-related outcomes
Addictive Behaviors Reports, 2021 Introduction: Cocaine (including powder and crack) use is common among people with HIV (PWH). We identified socio-demographic and behavioral factors associated with cocaine use (overall and various forms) among PWH; we also examined differences in HIV ...
Yiyang Liu +4 more
doaj +1 more source
Pauci-immune glomerulonephritis in individuals with disease associated with levamisole-adulterated cocaine: a series of 4 cases. [PDF]
, 2014 Exposure to levamisole-adulterated cocaine can induce a distinct clinical syndrome characterized by retiform purpura and/or agranulocytosis accompanied by an unusual constellation of serologic abnormalities including antiphospholipid antibodies, lupus ...
Butcher, Brad +6 more
core +2 more sources
Silent Cocaine Poisoning [PDF]
Asia Pacific Journal of Medical Toxicology, 2014 Background: Cocaine poisoning is known for causing severe clinical effects such as tachycardia, hypertension, agitation and confusion. Absence of clinical manifestations in cocaine poisoning is unusual.
Rachid El-Jaoudi +5 more
doaj
Opposing Regulation of Cocaine Seeking by Glutamate and GABA Neurons in the Ventral Pallidum
Cell Reports, 2020 Summary: Projections from the nucleus accumbens to the ventral pallidum (VP) regulate relapse in animal models of addiction. The VP contains GABAergic (VPGABA) and glutamatergic (VPGlu) neurons, and a subpopulation of GABAergic neurons co-express ...
Jasper A. Heinsbroek +6 more
doaj +1 more source
Frontiers in Neuroscience, 2022 Studies using either continuous or intermittent access cocaine self-administration procedures showed that cocaine seeking increases during abstinence (incubation of cocaine craving), and that this effect is higher after intermittent cocaine access. Other
Celine Nicolas +3 more
doaj +1 more source
From traumatic childhood to cocaine abuse: the critical function of the immune system [PDF]
, 2018 Background: Experiencing traumatic childhood is a risk factor for developing substance use disorder (SUD), but the mechanisms that underlie this relationship have not been determined.
Aricò, Eleonora +17 more
core +1 more source
Frontiers in Pharmacology, 2022 Mechanistic target of rapamycin (mTOR) C1 and its downstream effectors have been implicated in synaptic plasticity and memory. Our prior work demonstrated that reactivation of cocaine memory engages a signaling pathway consisting of Akt, glycogen ...
Xiangdang Shi +7 more
doaj +1 more source