Results 41 to 50 of about 40,355 (156)
ChatGPT in Drug Discovery: A Case Study on Anti-Cocaine Addiction Drug Development with Chatbots [PDF]
arXiv, 2023 The birth of ChatGPT, a cutting-edge language model-based chatbot developed by OpenAI, ushered in a new era in AI. However, due to potential pitfalls, its role in rigorous scientific research is not clear yet. This paper vividly showcases its innovative application within the field of drug discovery.
arxiv
A mechanism for the inhibition of neural progenitor cell proliferation by cocaine.
PLoS Medicine, 2008 BackgroundPrenatal exposure of the developing brain to cocaine causes morphological and behavioral abnormalities. Recent studies indicate that cocaine-induced proliferation inhibition and/or apoptosis in neural progenitor cells may play a pivotal role in
Chun-Ting Lee +13 more
doaj +1 more source
Ibrutinib as a potential therapeutic for cocaine use disorder
Translational Psychiatry, 2021 Cocaine use presents a worldwide public health problem with high socioeconomic cost. No current pharmacologic treatments are available for cocaine use disorder (CUD) or cocaine toxicity.
Spencer B. Huggett +7 more
doaj +1 more source
Clinical Cardiology, 2010 AbstractThe use of cocaine may be associated with either acute or chronic toxicity, and approximately 5% to 10% of emergency department visits in the United States are believed to be secondary to cocaine usage. Chest pain is the most common cocaine‐related medical problem, leading to the evaluation of approximately 64 000 patients annually for possible
Maraj, Suraj +2 more
openaire +3 more sources
Melatonin decreases cocaine-induced locomotor activity in pinealectomized rats
Brazilian Journal of PsychiatryObjective: Several studies have shown that the time of day regulates the reinforcing effects of cocaine. Additionally, melatonin and its MT1 and MT2 receptors have been found to participate in modulation of the reinforcing effects of such addictive drugs
Susana Barbosa-Méndez +1 more
doaj +1 more source
Cocaine modulates locomotion behavior in C. elegans.
PLoS ONE, 2009 Cocaine, a potent addictive substance, is an inhibitor of monoamine transporters, including DAT (dopamine transporter), SERT (serotonin transporter) and NET (norepinephrine transporter).
Alex Ward +3 more
doaj +1 more source
Evaluation of Cocaine Effect on Endogenous Metabolites of HepG2 Cells Using Targeted Metabolomics
Molecules, 2021 Cocaine toxicity has been a subject of study because cocaine is one of the most common and potent drugs of abuse. In the current study the effect of cocaine on human liver cancer cell line (HepG2) was assessed.
Adamantios Krokos +7 more
doaj +1 more source