Results 51 to 60 of about 40,355 (156)
Chemical Shifts in Molecular Solids by Machine Learning [PDF]
Nature Communications 9, 4501 (2018), 2018 The calculation of chemical shifts in solids has enabled methods to determine crystal structures in powders. The dependence of chemical shifts on local atomic environments sets them among the most powerful tools for structure elucidation of powdered solids or amorphous materials. Unfortunately, this dependency comes with the cost of high accuracy first-
arxiv +1 more source
Addiction Neuroscience, 2023 Drug associated cues are a common relapse trigger for individuals recovering from cocaine use disorder. Sex and ovarian hormones influence patterns of cocaine use and relapse vulnerability, with studies indicating that females show increased cue-induced ...
Claire M. Corbett +2 more
doaj
Genetic and epigenetic analysis of the serotonin 2A receptor in the context of cocaine abuse
Epigenetics, 2022 Despite more than 2 million American cocaine users monthly, there is no approved drug for treating cocaine use disorder. Cocaine use disorder has a multifactorial aetiology, including both genetic and environmental factors.
Aysheh Alrfooh, Ryan M. Smith
doaj +1 more source
Sensitivity analysis for constructing optimal regimes in the presence of treatment non-compliance [PDF]
arXiv, 2022 The current body of research on developing optimal treatment strategies often places emphasis on intention-to-treat analyses, which fail to take into account the compliance behavior of individuals. Methods based on instrumental variables have been developed to determine optimal treatment strategies in the presence of endogeneity.
arxiv
Conditioned Contribution of Peripheral Cocaine Actions to Cocaine Reward and Cocaine-Seeking [PDF]
Neuropsychopharmacology, 2013 Cocaine has actions in the peripheral nervous system that reliably precede--and thus predict--its soon-to-follow central rewarding effects. In cocaine-experienced animals, the peripheral cocaine signal is relayed to the central nervous system, triggering excitatory input to the ventral tegmental origin of the mesocorticolimbic dopamine system, the ...
Stephanie E. Myal +5 more
openaire +3 more sources
The Effects of Excitatory and Inhibitory Social Cues on Cocaine-Seeking Behavior
Frontiers in Behavioral Neuroscience, 2016 Social partners influence the likelihood of using drugs, developing a substance use disorder, and relapse to drug use after a period of abstinence. Preclinical studies report that social cues influence the acquisition of cocaine use, the escalation of ...
Mark Andrew Smith +2 more
doaj +1 more source
Reduced cue-induced reinstatement of cocaine-seeking behavior in Plcb1 +/− mice
Translational Psychiatry, 2021 Cocaine addiction causes serious health problems, and no effective treatment is available yet. We previously identified a genetic risk variant for cocaine addiction in the PLCB1 gene and found this gene upregulated in postmortem brains of cocaine abusers
Judit Cabana-Domínguez +5 more
doaj +1 more source
Frontiers in Psychiatry, 2022 Adolescent drug use reliably predicts increased addiction liability in adulthood, but not all individuals are equally impacted. To explore the biological bases of this differential reactivity to early life drug experience, we used a genetic rat model of ...
Aram Parsegian +9 more
doaj +1 more source