Results 51 to 60 of about 307,196 (303)

Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion. [PDF]

PLoS ONE, 2012
Mice and rats were tested for reduced sensitivity to cocaine-induced hyper-locomotion after pretreatment with anti-cocaine antibody or cocaine hydrolase (CocH) derived from human butyrylcholinesterase (BChE). In Balb/c mice, direct i.p. injection of CocH
Marilyn E Carroll, Natalie E Zlebnik, Justin J Anker, Thomas R Kosten, Frank M Orson, Xiaoyun Shen, Berma Kinsey, Robin J Parks, Yang Gao, Stephen Brimijoin   +9 more
doaj   +1 more source

Drug poisonings following bariatric surgery: Case series report

British Journal of Clinical Pharmacology, EarlyView.
Bariatric surgery alters gastrointestinal anatomy and physiology, which likely impacts upon oral medication absorption. Drug‐ and alcohol‐related deaths in this population are being increasingly reported; however, toxicological detail is lacking. Using data reported to the National Programme on Substance Use Mortality, we identified 18 deaths in people
Eman Mshari, Fannie LaJeunesse‐Trempe, Stephen Morley, Caroline Copeland   +3 more
wiley   +1 more source

Melatonin decreases cocaine-induced locomotor activity in pinealectomized rats

Brazilian Journal of Psychiatry
Objective: Several studies have shown that the time of day regulates the reinforcing effects of cocaine. Additionally, melatonin and its MT1 and MT2 receptors have been found to participate in modulation of the reinforcing effects of such addictive drugs
Susana Barbosa-Méndez, Alberto Salazar-Juárez   +1 more
doaj   +1 more source

Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes.

PLoS ONE, 2013
ObjectiveThe search for genetic vulnerability factors in cocaine dependence has focused on the role that neuroplasticity plays in addiction. However, like many other drugs, the ability of an individual to metabolize cocaine can also influence ...
André Brooking Negrão, Alexandre Costa Pereira, Camila Guindalini, Hadassa Campos Santos, Guilherme Peres Messas, Ronaldo Laranjeira, Homero Vallada   +6 more
doaj   +1 more source

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

A mechanism for the inhibition of neural progenitor cell proliferation by cocaine.

PLoS Medicine, 2008
BackgroundPrenatal exposure of the developing brain to cocaine causes morphological and behavioral abnormalities. Recent studies indicate that cocaine-induced proliferation inhibition and/or apoptosis in neural progenitor cells may play a pivotal role in
Chun-Ting Lee, Jia Chen, Teruo Hayashi, Shang-Yi Tsai, Joseph F Sanchez, Stacie L Errico, Rose Amable, Tsung-Ping Su, Ross H Lowe, Marilyn A Huestis, James Shen, Kevin G Becker, Herbert M Geller, William J Freed   +13 more
doaj   +1 more source

Hypocretin / Orexin Receptor 1 Knockdown in GABA or Dopamine Neurons in the Ventral Tegmental Area Differentially Impact Mesolimbic Dopamine and Motivation for Cocaine

Addiction Neuroscience, 2023
The hypocretins/orexins (HCRT) have been demonstrated to influence motivation for cocaine through actions on dopamine (DA) transmission. Pharmacological or genetic disruption of the hypocretin receptor 1 (Hcrtr1) reduces cocaine self-administration ...
Emily M. Black, Shanna B. Samels, Wei Xu, Jessica R. Barson, Caroline E. Bass, Sandhya Kortagere, Rodrigo A. España   +6 more
doaj   +1 more source

Adolescent D-amphetamine treatment in a rodent model of attention deficit/hyperactivity disorder: impact on cocaine abuse vulnerability in adulthood [PDF]

, 2016
RATIONALE: Stimulant medications for attention-deficit/hyperactivity disorder (ADHD) in adolescents remain controversial with respect to later development of cocaine abuse.
Dwoskin, Linda P., Jordan, Chloe J., Kantak, Kathleen M., Lemay, Carley   +3 more
core   +1 more source

Cocaine-induced Vasculitis [PDF]

Rambam Maimonides Medical Journal, 2016
The use of cocaine continues to grow worldwide. One of the possible side-effects of cocaine is vasculitis. Two distinct vasculitic syndromes have been described due to cocaine. One is cocaine-induced midline destructive lesion, secondary to a direct vasoconstrictor effect of cocaine, inducing ischemic necrosis of the septal cartilage and perforation of
Mark Berman, Daphna Paran, Ori Elkayam
openaire   +3 more sources

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source