Results 91 to 100 of about 16,526 (214)

Solubility and Stability Advantages of a New Cocrystal of Berberine Chloride with Fumaric Acid

ACS Omega, 2020
BBC is a drug with a variety of activities but poor solubility. Cocrystal technology is an effective method to improve the solubility and stability of this type of compound.
Dezhi Yang, Junzi Cao, Lingtai Jiao, Shiying Yang, Li Zhang, Yang Lu, Guan-hua Du   +6 more
semanticscholar   +1 more source

Semiconducting Quasi One‐Dimensional (PbBr2)[Pb2P14]2, a Lead Bromide Adduct and Violet Phosphorus Derivative

Zeitschrift für anorganische und allgemeine Chemie, EarlyView.
The quasi‐one‐dimensional semiconductor Pb5Br2P28 was examined in terms of its structural and electronic properties. Single‐crystal X‐ray diffraction (SC‐XRD) and Raman spectroscopy support its description as neutral [Pb2P14] and [PbBr2] units. Combined with its semiconducting properties and high flexibility, Pb5Br2P28 emerges as a promising candidate ...
Kathrin Vosseler, Felipe Jacques Lima Duarte, Tom Nilges   +2 more
wiley   +1 more source

Spectral characterization and vibrational mode study of cocrystal of acetaminophen and aspirin based on terahertz/Raman spectroscopy combined with DFT theory calculation

Results in Chemistry
In recent years, pharmaceutical cocrystal has become a hot field in drug development, which improves the solubility, stability, and bioavailability of drugs.
Haofei Sun, Bo Peng, Xinyi Bai, Bo Su, Cunlin Zhang, Hailin Cui, Shengbo Zhang, Kai Li   +7 more
doaj   +1 more source

A Hanks‐type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation

The FEBS Journal, EarlyView.
The Xanthomonas citri Hanks‐type kinase PknS autophosphorylates and directly phosphorylates the alternative sigma factor EcfK at five residues. Besides the conserved residue T51 in the σ2 domain, phosphorylation of a residue in the linker between σ2 and σ4 is critical for EcfK activation by promoting its interaction with a positively charged pocket in ...
Lídia dos Passos Lima, Dev Sriranganadane, Daiane Laise da Silva, Natália C. Drebes Dörr, Enzo Breviglieri Sichi Mello, Caio Vinicius dos Reis, Rogério Ferreira Lourenço, José Felipe Teixeira da Silva Santos, Anita Salmazo, Brenno Wendler Miranda, Katlin B. Massirer, Rafael M. Couñago, Cristina E. Alvarez‐Martinez   +12 more
wiley   +1 more source

Comparative evaluation of noncanonical amino acids as site‐specific NMR probes for the complex of E. coli SSB with single‐stranded DNA without isotope labelling

The FEBS Journal, EarlyView.
Genetic encoding of noncanonical amino acids (ncAA) enables their site‐specific installation in proteins. This work compares the nuclear magnetic resonance (NMR) performance of different ncAAs in a large protein−DNA complex (~ 100 kDa) without isotope labelling. The ncAAs deliver readily detectable NMR signals in the complex between E.
Sreelakshmi Mekkattu Tharayil, Haocheng Qianzhu, Elwy H. Abdelkader, Adarshi P. Welegedara, Josemon George, Christoph Nitsche, Thomas Huber, Gottfried Otting   +7 more
wiley   +1 more source

Effects of the Glass-Forming Ability and Annealing Conditions on Cocrystallization Behaviors via Rapid Solvent Removal: A Case Study of Voriconazole

Pharmaceutics, 2020
The kinetic entrapment of molecules in an amorphous phase is a common obstacle to cocrystal screening using rapid solvent removal, especially for drugs with a moderate or high glass-forming ability (GFA).
Si Nga Wong, Susan Wing Sze Chan, Xuexin Peng, Bianfei Xuan, Hok Wai Lee, Henry H. Y. Tong, Shing Fung Chow   +6 more
doaj   +1 more source

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel, Manuel J. Verganista, Nuno R. Candeias   +2 more
wiley   +1 more source

Research progress of high energy CL-20/HMX cocrystal explosive

Results in Chemistry
Cocrystal belongs to supramolecular chemistry and it is generally composed of different components including molecules, ions with certain molecular ratio and typical structure.
Guiyun Hang, Jintao Wang, Haijian Xue, Tao Wang, Wenli Yu, Huiming Shen   +5 more
doaj   +1 more source

Structural Characterization of Febuxostat/l-Pyroglutamic Acid Cocrystal Using Solid-State 13C-NMR and Investigational Study of Its Water Solubility

Crystals, 2017
Febuxostat (FB) is a poorly water-soluble drug that belongs to BCS class II. The drug is employed for the treatment of inflammatory disease arthritis urica (gout), and the free base, FB form-A, is most preferred for drug formulation.
Ji-Hun An, Changjin Lim, Hyung Chul Ryu, Jae Sun Kim, Hyuk Min Kim, Alice Nguvoko Kiyonga, Minho Park, Young-Ger Suh, Gyu Hwan Park, Kiwon Jung   +9 more
doaj   +1 more source

Synthesis, Properties, Applications and Challenges of Multicomponent Doped Organic Room Temperature Phosphorescence Materials

Aggregate, Volume 7, Issue 3, March 2026.
The multi‐component doping strategy, involving self‐assembly, host‐guest systems, and crystal engineering, has gained attention for its simplicity, cost‐effectiveness, structural diversity, and adjustable room‐temperature phosphorescence (RTP). This review summarizes and evaluates the progress in creating RTP materials using this strategy, highlighting
Zhenjie Zhou, Huizhong Wang, Junxiong Yao, Tian Wang, Jianhua Liu, Xiaohua Cao, Qiang Feng, Bingbing Yue, Dianyuan Wang, Jianguo Wang, Huanan Huang   +10 more
wiley   +1 more source