Results 91 to 100 of about 23,789 (261)

Mechanochemical Synthesis of Pharmaceutical Cocrystal Suspensions via Hot Melt Extrusion: Enhancing Cocrystal Yield [PDF]

Molecular Pharmaceutics, 2017
Pharmaceutical cocrystals have attracted increasing attention over the past decade as an alternative way to modify the physicochemical properties and hence improve the bioavailability of a drug, without sacrificing thermodynamic stability. Our previous work has demonstrated the viability of in situ formation of ibuprofen/isonicotinamide cocrystal ...
Shu Li, Tao Yu, Yiwei Tian, Colette Lagan, David S. Jones, Gavin P. Andrews   +5 more
openaire   +4 more sources

Insight into flufenamic acid cocrystal dissolution in the presence of a polymer in solution: from single crystal to powder dissolution [PDF]

, 2017
Effects of three polymers, polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), and copolymer of vinylpyrrolidone/vinyl acetate (PVP-VA), on the dissolution behavior of the cocrystals of flufenamic acid with theophylline (FFA-TP CO) and nicotinamide ...
Fábián, László, Guo, Minshan, Li, Mingzhong, Qiao, Ning, Sadiq, Ghazala, Wang, Ke   +5 more
core   +2 more sources

Near‐Infrared Cocrystal Nanofluorophore with Enhanced Two‐Photon Absorption Cross Sections

Advanced Science, EarlyView.
In this study, organic cocrystal nanoparticles (BP4TC‐NPs) were prepared via a nanoprecipitation method using an amphiphilic surfactant. The resulting cocrystal nanoparticles exhibit exceptional nonlinear optical properties and bioimaging capabilities.
Liangmeng Hao, Ying Ni, Jiawei Huang, Yucheng Wang, Fan Liu, Xu Wang, Lei Kang, Zheshuai Lin, Weigang Zhu   +8 more
wiley   +1 more source

Four Novel Pharmaceutical Cocrystals of Oxyresveratrol, Including a 2 : 3 Cocrystal with Betaine

Chemical and Pharmaceutical Bulletin, 2021
Cocrystal engineering can alter the physicochemical properties of a drug and generate a superior drug candidate for formulation design. Oxyresveratrol (ORV) exhibits a poor solubility in aqueous environments, thereby resulting in a poor bioavailability.
Nasa, Sakamoto, Naoya, Tsuno, Ryotaro, Koyama, Katsuhiko, Gato, Varin, Titapiwatanakun, Kazuhiko, Takatori, Toshiro, Fukami   +6 more
openaire   +3 more sources

Crystal Structures, Thermal Analysis, and Dissolution Behavior of New Solid Forms of the Antiviral Drug Arbidol with Dicarboxylic Acids

Crystals, 2015
Salts of the antiviral drug arbidol (umifenovir) (Arb) with maleate (Mlc) and fumarate (Fum) anions have been obtained, and their crystal structures have been described.
Alex N. Manin, Artem O. Surov, Andrei V. Churakov, German L. Perlovich   +3 more
doaj   +1 more source

Supramolecular Hierarchy among Halogen-Bond Donors [PDF]

, 2013
Through a combination of structural chemistry, vibrational spectroscopy, and theory, we have systematically examined the relative structure-directing importance of a series of ditopic halogen-bond (XB) donors.
CB. Aakeröy, G. Resnati, J. Desper, M. Baldrighi, P. Metrangolo   +4 more
core   +1 more source

Mechanochromic Organic Materials: Molecular Mechanisms and Multidimensional Applications

Advanced Physics Research, EarlyView.
Mechanochromic (MC) organic materials change color in response to mechanical force. This review elucidates the molecular mechanisms (e.g., aggregation‐induced emission, AIE) and explores their multidimensional applications in sensors, anti‐counterfeiting, biomedical devices, and structural health monitoring, providing a roadmap for future smart ...
Xiaozhe Yin, Guoliang Niu, Yu Wang, Angela Wittmann, Huiyang Gou, Lang Jiang   +5 more
wiley   +1 more source

Solid-state characterization of novel active pharmaceutical ingredients: Cocrystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt. [PDF]

, 2013
The production of salt or cocrystalline forms is a common approach to alter the physicochemical properties of pharmaceutical compounds. The goal of this work was to evaluate the impact of anion choice (succinate, adipate, and sulfate) on the ...
Corrigan, Owen I., Elcoate, Curtis J., Healy, Anne Marie, Lawrence, Simon E., Paluch, Krzysztof J., Tajber, Lidia   +5 more
core   +1 more source

Stafib‐2‐CR: an Improved Nanomolar and Selective Inhibitor of the Transcription Factor STAT5b Developed by Conformational Restriction of Stafib‐2

Chemistry – A European Journal, EarlyView.
Conformational restriction strategies to increase the activity and selectivity of the STAT5b inhibitor Stafib‐2 are presented. The best conformationally restricted inhibitor Stafib‐2‐CR has threefold higher activity against STAT5b than Stafib‐2. A cell‐permeable prodrug of Stafib‐2‐CR inhibits phosphorylation of STAT5b in cultured human leukemia cells ...
Theresa Münzel, Angela Berg, Christoph Protzel, Sylvie Schäfer, Alexander Jensen‐Feinhals, Thorsten Berg   +5 more
wiley   +1 more source

Bioavailability of indomethacin-saccharin cocrystals

Journal of Pharmacy and Pharmacology, 2010
Abstract Objectives Pharmaceutical cocrystals are new solid forms with physicochemical properties that appear promising for drug product development. However, the in-vivo bioavailability of cocrystals has rarely been addressed.
Min-Sook, Jung, Jeong-Soo, Kim, Min-Soo, Kim, Amjad, Alhalaweh, Wonkyung, Cho, Sung-Joo, Hwang, Sitaram P, Velaga   +6 more
openaire   +2 more sources