Results 111 to 120 of about 23,789 (261)

Spectral characterization and vibrational mode study of cocrystal of acetaminophen and aspirin based on terahertz/Raman spectroscopy combined with DFT theory calculation

Results in Chemistry
In recent years, pharmaceutical cocrystal has become a hot field in drug development, which improves the solubility, stability, and bioavailability of drugs.
Haofei Sun, Bo Peng, Xinyi Bai, Bo Su, Cunlin Zhang, Hailin Cui, Shengbo Zhang, Kai Li   +7 more
doaj   +1 more source

Organic Cocrystals: Recent Advances and Perspectives for Electronic and Magnetic Applications [PDF]

, 2021
Mengjia Jiang, Chun Zhen, Shuyu Li, Xiaotao Zhang, Wenping Hu   +4 more
openalex   +1 more source

A Hanks‐type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation

The FEBS Journal, EarlyView.
The Xanthomonas citri Hanks‐type kinase PknS autophosphorylates and directly phosphorylates the alternative sigma factor EcfK at five residues. Besides the conserved residue T51 in the σ2 domain, phosphorylation of a residue in the linker between σ2 and σ4 is critical for EcfK activation by promoting its interaction with a positively charged pocket in ...
Lídia dos Passos Lima, Dev Sriranganadane, Daiane Laise da Silva, Natália C. Drebes Dörr, Enzo Breviglieri Sichi Mello, Caio Vinicius dos Reis, Rogério Ferreira Lourenço, José Felipe Teixeira da Silva Santos, Anita Salmazo, Brenno Wendler Miranda, Katlin B. Massirer, Rafael M. Couñago, Cristina E. Alvarez‐Martinez   +12 more
wiley   +1 more source

Research progress of high energy CL-20/HMX cocrystal explosive

Results in Chemistry
Cocrystal belongs to supramolecular chemistry and it is generally composed of different components including molecules, ions with certain molecular ratio and typical structure.
Guiyun Hang, Jintao Wang, Haijian Xue, Tao Wang, Wenli Yu, Huiming Shen   +5 more
doaj   +1 more source

Structural Properties, Order-Disorder Phenomena and Phase Stability of Orotic Acid Crystal Forms [PDF]

, 2016
Orotic acid (OTA) is reported to exist in the anhydrous (AH), monohydrate (Hy1) and dimethylsulfoxide monosolvate (SDMSO) forms. In this study we investigate the (de)hydration/desolvation behavior, aiming at an understanding of the elusive structural ...
Brittain H. G., Brittain H. G., Byrn S. R., Clark J. R., Doris E. Braun, Frisch M. J., Gal S., Griesser U. J., Karol P. Nartowski, Kenneth R. Morris, Stephen R. Byrn, Ulrich J. Griesser, Yaroslav Z. Khimyak   +12 more
core   +3 more sources

De Novo Design and Synthesis of Novel Benzoxazinone Derivatives Targeting Dihydroxyacid Dehydratase

Plant Biotechnology Journal, EarlyView.
ABSTRACT Dihydroxyacid dehydratase (DHAD), a key enzyme in the branched‐chain amino acid (BCAA) synthesis pathway, is a promising herbicide target. Currently, no commercial herbicides target DHAD, and no inhibitors are in development. Structural analysis suggests that coordination with iron–sulfur clusters and hydrophobic interactions with Tyr215 and ...
Bo He, Yanhao Hu, Xu He, Wang Chen, Wei Yan, Xin Zang, Jiahai Zhou, Yonghao Ye   +7 more
wiley   +1 more source

Effects of the Glass-Forming Ability and Annealing Conditions on Cocrystallization Behaviors via Rapid Solvent Removal: A Case Study of Voriconazole

Pharmaceutics, 2020
The kinetic entrapment of molecules in an amorphous phase is a common obstacle to cocrystal screening using rapid solvent removal, especially for drugs with a moderate or high glass-forming ability (GFA).
Si Nga Wong, Susan Wing Sze Chan, Xuexin Peng, Bianfei Xuan, Hok Wai Lee, Henry H. Y. Tong, Shing Fung Chow   +6 more
doaj   +1 more source

BindingDB in 2015: A public database for medicinal chemistry, computational chemistry and systems pharmacology. [PDF]

, 2015
BindingDB, www.bindingdb.org, is a publicly accessible database of experimental protein-small molecule interaction data. Its collection of over a million data entries derives primarily from scientific articles and, increasingly, US patents.
Baitaluk, Michael, Chong, Jenny, Gilson, Michael K, Hwang, Linda, Liu, Tiqing, Nicola, George   +5 more
core   +1 more source

Fluorescent proteins: A journey from the cell to extreme environments in material science

Photochemistry and Photobiology, EarlyView.
Applications of proteins and microorganisms as tools or effectors in material science. Abstract This review presents the progression from the use of fluorescent proteins (FPs) and chromoproteins as bioimaging labels and sensors to the strategic engineering of their properties for robust functionality in synthetic and non‐biological environments ...
Bianca Menchicchi, Andre C. Stiel, Mattia Nieddu, J. P. Fuenzalida‐Werner   +3 more
wiley   +1 more source

Structural Characterization of Febuxostat/l-Pyroglutamic Acid Cocrystal Using Solid-State 13C-NMR and Investigational Study of Its Water Solubility

Crystals, 2017
Febuxostat (FB) is a poorly water-soluble drug that belongs to BCS class II. The drug is employed for the treatment of inflammatory disease arthritis urica (gout), and the free base, FB form-A, is most preferred for drug formulation.
Ji-Hun An, Changjin Lim, Hyung Chul Ryu, Jae Sun Kim, Hyuk Min Kim, Alice Nguvoko Kiyonga, Minho Park, Young-Ger Suh, Gyu Hwan Park, Kiwon Jung   +9 more
doaj   +1 more source