Results 11 to 20 of about 16,526 (214)

Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications [PDF]

Crystal Growth & Design, 2018
Originally discovered almost a century ago, cocrystals continue to gain interest in the modern day due to their ability to modify the physical properties of solid-state materials, particularly pharmaceuticals.
M. Karimi-Jafari, L. Padrela, G. Walker, D. Croker   +3 more
semanticscholar   +2 more sources

Beyond Cocrystals: Hierarchical Functional Assemblies via Noncovalent Synthesis. [PDF]

Adv Sci (Weinh)
Non‐covalent interactions (NCIs) drive the formation of organic cocrystals with diverse structures and tunable optoelectronic properties. This review explores the essential factors governing these properties, highlighting how the sequential nucleation of cocrystals leads to the self‐assembly of organic hierarchical structures (OHSs).
Zhu YN, Feng J, Ma YX, Lin HT, Xie LW, Peng QL, Wang XD.   +6 more
europepmc   +2 more sources

Organic Binary and Ternary Cocrystal Engineering Based on Halogen Bonding Aimed at Room‐Temperature Phosphorescence

Advances in Materials, 2023
Recently, there has been intense interest in pure organic room‐temperature phosphorescence (ORTP) from cocrystals composed of 1,4‐diiodotetrafluorobenzene (DITFB) and a variety of polycyclic aromatic hydrocarbons (PAHs) or their derivatives.
Ayano Abe, K. Goushi, Masashi Mamada, C. Adachi   +3 more
semanticscholar   +1 more source

A Randomized, Double-Blind, Two-Treatment, Two-Period, Crossover Study Investigating the Systemic Bioavailability of a Novel Cocrystal Ubiquinol Formulation Compared with a Ubiquinone Formulation in Healthy Adults. [PDF]

Clin Pharmacol Drug Dev
Abstract Coenzyme Q10 (CoQ10) is a naturally occurring biochemical cofactor found in all human cell membranes in two interconvertible forms: oxidized ubiquinone and reduced ubiquinol. Clinical studies indicate that different CoQ10 formulations have different absorption rates, highlighting research comparing their systemic bioavailability.
Mei X, Zhu B, Soni K, Kasaraneni K, Panchal N.   +4 more
europepmc   +2 more sources

Polymorphism in Carbamazepine Cocrystals [PDF]

Crystal Growth & Design, 2008
Cocrystals of carbamazepine with nicotinamide and saccharin are shown to be polymorphic. Two polymorphs of carbamazepine-nicotinamide (CBZ-NCT) cocrystals and two polymorphs of carbamazepine-saccharin (CBZ-SAC) cocrystals were grown from solution in the presence of polymer heteronuclei. The two CBZ-NCT polymorphs, CBZ-NCT I and a polymer nucleated (PN)
William W, Porter, Sophia C, Elie, Adam J, Matzger   +2 more
openaire   +2 more sources

Morphology and properties of CL-20/MTNP cocrystal prepared via facile spray drying

FirePhysChem, 2023
Cocrystal of 2,4,6,8,10,12-hexaazaisowurtzitane/1-methyl-3,4,5-trinitropyrazole (CL-20/MTNP) in a 1:1 molar ratio is a promising energetic material, since it combines the superior detonation performance of CL-20 and good mechanical sensitivity of MTNP ...
Xueyan Zhao, Zongwei Yang, Shen Qiao, Junyu Piao, Hongzhen Li   +4 more
doaj   +1 more source

Cocrystals of Modafinil-Nicotinic Acid: A Novel Cocrystal for Enhanced Bioavailability [PDF]

The 2nd International Online Conference on Crystals, 2020
In this work, we are the first to identify and report pharmaceutically effective cocrystals of the poorly soluble drug Modafinil (MOD) using a crystal engineering approach. A multi-component system of MOD with nicotinic acid (NIC) as the coformer at a 1:1 molar ratio was prepared to simultaneously improve the solubility, dissolution and bioavailability
Tanmoy Ghosh, Thimmasetty Juturu, Shashank Nayak Nagar, Shwetha Kamath   +3 more
openaire   +3 more sources

Cocrystals Enhance Biopharmaceutical and Antimicrobial Properties of Norfloxacin

Pharmaceutics, 2023
A solvate cocrystal of the antimicrobial norfloxacin (NFX) was formed by using isonicotinamide (INA) as a coformer with the solvent evaporation technique. The cocrystal formation was confirmed by performing solid-state characterization techniques.
Samantha Nascimento Gomes, Isabela Fanelli Barreto Biscaia, Diana Schon Lopes, Mariana Mengarda, Fábio Seigi Murakami, Paulo Renato Oliveira, Larissa Sakis Bernardi   +6 more
doaj   +1 more source

Rational Development of a Carrier-Free Dry Powder Inhalation Formulation for Respiratory Viral Infections via Quality by Design: A Drug-Drug Cocrystal of Favipiravir and Theophylline

Pharmaceutics, 2022
Formulating pharmaceutical cocrystals as inhalable dosage forms represents a unique niche in effective management of respiratory infections. Favipiravir, a broad-spectrum antiviral drug with potential pharmacological activity against SARS-CoV-2, exhibits
S. Wong, J. Weng, Ignatius Ip, Ruipeng Chen, R. Lakerveld, Richard Telford, N. Blagden, I. Scowen, S. F. Chow   +8 more
semanticscholar   +1 more source

Effects of polyvinylpyrrolidone and poly (ethylene glycol) on preparation of ibuprofen pharmaceutical cocrystal

Brazilian Journal of Pharmaceutical Sciences, 2023
In this study, we investigated the effects of polymers on the pharmaceutical cocrystal formation process. Ibuprofen (IBU) was selected as the active pharmaceutical ingredient (API), nicotinamide (NIC) and saccharin (SAC) as the cocrystal coformer (CCF ...
Xintong Yang, Yang Chen, Ning Qiao
doaj   +1 more source