Results 11 to 20 of about 23,789 (261)
Mechanosynthesis of Higher‐Order Cocrystals: Tuning Order, Functionality and Size in Cocrystal Design** [PDF]
Angewandte Chemie International Edition, 2021 Abstract The ability to rationally design and predictably construct crystalline solids has been the hallmark of crystal engineering research. To date, numerous examples of multicomponent crystals comprising organic molecules have been reported.
Zi Xuan Ng +10 more
openalex +6 more sources
Polymorphism in Carbamazepine Cocrystals [PDF]
Crystal Growth & Design, 2008 Cocrystals of carbamazepine with nicotinamide and saccharin are shown to be polymorphic. Two polymorphs of carbamazepine-nicotinamide (CBZ-NCT) cocrystals and two polymorphs of carbamazepine-saccharin (CBZ-SAC) cocrystals were grown from solution in the presence of polymer heteronuclei. The two CBZ-NCT polymorphs, CBZ-NCT I and a polymer nucleated (PN)
William W, Porter +2 more
openaire +2 more sources
Cocrystals of Modafinil-Nicotinic Acid: A Novel Cocrystal for Enhanced Bioavailability [PDF]
The 2nd International Online Conference on Crystals, 2020 In this work, we are the first to identify and report pharmaceutically effective cocrystals of the poorly soluble drug Modafinil (MOD) using a crystal engineering approach. A multi-component system of MOD with nicotinic acid (NIC) as the coformer at a 1:1 molar ratio was prepared to simultaneously improve the solubility, dissolution and bioavailability
Tanmoy Ghosh +3 more
openaire +3 more sources
Brazilian Journal of Pharmaceutical Sciences, 2023 In this study, we investigated the effects of polymers on the pharmaceutical cocrystal formation process. Ibuprofen (IBU) was selected as the active pharmaceutical ingredient (API), nicotinamide (NIC) and saccharin (SAC) as the cocrystal coformer (CCF ...
Xintong Yang, Yang Chen, Ning Qiao
doaj +1 more source
Salts, Cocrystals, and Ionic Cocrystals of a “Simple” Tautomeric Compound [PDF]
Crystal Growth & Design, 2018 We have investigated the cocrystallisation behaviour of AHMP (2-amino-6-methyl-1,4-dihydropyrimidin-4-one) with a series of acids and imide coformers.Being a base able to tautomerise, at the molecular level, AHMP may exist as three different neutral tautomers or, if protonated, in the form of several cationic species.
Ting Wang +6 more
openaire +3 more sources
Formation of Ketoprofen-Malonic Acid Cocrystal by Solvent Evaporation Method
Indonesian Journal of Chemistry, 2017 The purpose of this work was to explore the formation of ketoprofen-malonic acid cocrystal by solvent evaporation method. Early detection of cocrystal formation was conducted by hot stage microscopy and solid-liquid phase diagram. Cocrystal were prepared
Yudi Wicaksono +2 more
doaj +1 more source
Karakterisasi Cocrystal Glibenklamida Dengan Variasi Pelarut dan Uji Stabilitas Termal
JPSCR: Journal of Pharmaceutical Science and Clinical Research, 2022 Glibenklamida termasuk dalam Biopharmaceutical Classification System (BCS) kelas II yaitu kelarutannya rendah. Kelarutan dapat ditingkatkan dengan dengan mengubah glibenklamida menjadi bentuk cocrystal.
Anang Kuncoro Rachmad Setiawan +2 more
doaj +1 more source
Extrusion - back to the future: using an established technique to reform automated chemical synthesis [PDF]
, 2016 YesHerein, the benefits which extrusion can provide for the automated continuous synthesis of organic compounds are highlighted. Extrusion is a well-established technique that has a vital role in the manufacturing processes of polymers, pharmaceuticals ...
Crawford, Deborah E.
core +2 more sources
Applied Sciences, 2021 Pharmaceutical cocrystallization offers the possibility to modify the physicochemical and biopharmaceutical properties of active pharmaceutical ingredients.
Juan Saulo González-González +4 more
doaj +1 more source
A carbamazepine-indomethacin (1:1) cocrystal produced by milling [PDF]
, 2011 An X-ray amorphous mixture of carbamazepine and indomethacin transforms upon annealing to produce a novel 1:1 cocrystal, whose structure has been determined from laboratory powder X-ray diffraction (PXRD ...
Buckton, Graham +6 more
core +1 more source