Results 21 to 30 of about 16,526 (214)
Crystal Growth & Design, 2022 The development of multicomponent crystal forms, such as cocrystals, represents a means to enhance the dissolution and absorption properties of poorly water-soluble drug compounds.
Matteo Guidetti +4 more
semanticscholar +1 more source
Pharmaceutical cocrystal of antibiotic drugs: A comprehensive review
Heliyon, 2022 Pharmaceutical cocrystals, which contain at least one active pharmaceutical ingredient (API), are still an attention-grabbing field for researchers. Two or more discrete molecules unite together by non-covalent bonds, e.g., hydrogen, Van der Waals, and π⋯
M. Bashimam, Hind El-Zein
semanticscholar +1 more source
Salts, Cocrystals, and Ionic Cocrystals of a “Simple” Tautomeric Compound [PDF]
Crystal Growth & Design, 2018 We have investigated the cocrystallisation behaviour of AHMP (2-amino-6-methyl-1,4-dihydropyrimidin-4-one) with a series of acids and imide coformers.Being a base able to tautomerise, at the molecular level, AHMP may exist as three different neutral tautomers or, if protonated, in the form of several cationic species.
Ting Wang +6 more
openaire +3 more sources
Mechanosynthesis of Higher‐Order Cocrystals: Tuning Order, Functionality and Size in Cocrystal Design** [PDF]
Angewandte Chemie International Edition, 2021 Abstract The ability to rationally design and predictably construct crystalline solids has been the hallmark of crystal engineering research. To date, numerous examples of multicomponent crystals comprising organic molecules have been reported.
Zi Xuan Ng +10 more
openaire +5 more sources
Pharmaceutics, 2021 Active pharmaceutical ingredients (APIs) extracted and isolated from traditional Chinese medicines (TCMs) are of interest for drug development due to their wide range of biological activities.
Danyingzi Guan +9 more
semanticscholar +1 more source
Formation of Ketoprofen-Malonic Acid Cocrystal by Solvent Evaporation Method
Indonesian Journal of Chemistry, 2017 The purpose of this work was to explore the formation of ketoprofen-malonic acid cocrystal by solvent evaporation method. Early detection of cocrystal formation was conducted by hot stage microscopy and solid-liquid phase diagram. Cocrystal were prepared
Yudi Wicaksono +2 more
doaj +1 more source
Applied Sciences, 2021 Pharmaceutical cocrystallization offers the possibility to modify the physicochemical and biopharmaceutical properties of active pharmaceutical ingredients.
Juan Saulo González-González +4 more
doaj +1 more source
Cocrystal Engineering of Conjugated Polymer Blends via External Electric Field for Enhanced Charge Transport. [PDF]
Adv Sci (Weinh)We report, for the first time, an external electric field (EEF) strategy to achieve co‐aggregation of conjugated polymer blends (i.e., poly(3‐butylthiophene) and poly[3,3'''‐dialkyl‐quaterthiophene]s) in the solution and thus their cocrystals in thin films, demonstrating cocrystal‐improved charge mobilities due to the synergy of two components ...
Guo Y, Zheng H, Peng J.
europepmc +2 more sources
Karakterisasi Cocrystal Glibenklamida Dengan Variasi Pelarut dan Uji Stabilitas Termal
JPSCR: Journal of Pharmaceutical Science and Clinical Research, 2022 Glibenklamida termasuk dalam Biopharmaceutical Classification System (BCS) kelas II yaitu kelarutannya rendah. Kelarutan dapat ditingkatkan dengan dengan mengubah glibenklamida menjadi bentuk cocrystal.
Anang Kuncoro Rachmad Setiawan +2 more
doaj +1 more source
Cocrystal Prediction Using Machine Learning Models and Descriptors
Applied Sciences, 2021 Cocrystals are of much interest in industrial application as well as academic research, and screening of suitable coformers for active pharmaceutical ingredients is the most crucial and challenging step in cocrystal development.
M. E. Mswahili +6 more
semanticscholar +1 more source