Results 11 to 20 of about 8,547 (185)
Salts, Cocrystals, and Ionic Cocrystals of a “Simple” Tautomeric Compound [PDF]
Crystal Growth & Design, 2018 We have investigated the cocrystallization behavior of AHMP (2-amino-6-methyl-1,4-dihydropyrimidin-4-one) with a series of acids and imide coformers. Being a base able to tautomerize, at the molecular level, AHMP may exist as three different neutral tautomers or, if protonated, in the form of several cationic species.
Ting Wang +6 more
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Polymorphism in Carbamazepine Cocrystals [PDF]
Crystal Growth & Design, 2008 Cocrystals of carbamazepine with nicotinamide and saccharin are shown to be polymorphic. Two polymorphs of carbamazepine-nicotinamide (CBZ-NCT) cocrystals and two polymorphs of carbamazepine-saccharin (CBZ-SAC) cocrystals were grown from solution in the presence of polymer heteronuclei. The two CBZ-NCT polymorphs, CBZ-NCT I and a polymer nucleated (PN)
William W, Porter +2 more
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Karakterisasi Cocrystal Glibenklamida Dengan Variasi Pelarut dan Uji Stabilitas Termal
JPSCR: Journal of Pharmaceutical Science and Clinical Research, 2022 Glibenklamida termasuk dalam Biopharmaceutical Classification System (BCS) kelas II yaitu kelarutannya rendah. Kelarutan dapat ditingkatkan dengan dengan mengubah glibenklamida menjadi bentuk cocrystal.
Anang Kuncoro Rachmad Setiawan +2 more
doaj +1 more source
Cocrystals of Modafinil-Nicotinic Acid: A Novel Cocrystal for Enhanced Bioavailability [PDF]
The 2nd International Online Conference on Crystals, 2020 In this work, we are the first to identify and report pharmaceutically effective cocrystals of the poorly soluble drug Modafinil (MOD) using a crystal engineering approach. A multi-component system of MOD with nicotinic acid (NIC) as the coformer at a 1:1 molar ratio was prepared to simultaneously improve the solubility, dissolution and bioavailability
Tanmoy Ghosh +3 more
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Preparation and Characterization of Carbamazepine Cocrystal in Polymer Solution
Pharmaceutics, 2017 In this study, we attempted to prepare carbamazepine (CBZ) cocrystal through the solution method in ethanol-water solvent mixture (volume ratio 1:1) and polyvinyl pyrrolidone (PVP) solution.
Hao Zhang +4 more
doaj +1 more source
Recent Advances in Pharmaceutical Cocrystals: A Focused Review of Flavonoid Cocrystals
Molecules, 2023 Cocrystallization is currently an attractive technique for tailoring the physicochemical properties of active pharmaceutical ingredients (APIs). Flavonoids are a large class of natural products with a wide range of beneficial properties, including anticancer, anti-inflammatory, antiviral and antioxidant properties, which makes them extensively studied.
Jia Xu +6 more
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Crystals, 2015 Liquid-assisted grinding was employed to generate a cocrystal of adefovir dipivoxil (AD) and glutaric acid (GLU), which had not been successfully obtained through solution crystallization.
Sungyup Jung, Insil Choi, Il Won Kim
doaj +1 more source
Investigation of the Formation Process of Two Piracetam Cocrystals during Grinding
Pharmaceutics, 2011 Cocrystal formation rates during dry grinding and liquid-assisted grinding were investigated by X-ray powder diffractometry and Raman spectroscopy. Two polymorphic forms of piracetam were used to prepare known piracetam cocrystals as model substances, i ...
Keith Gordon +7 more
doaj +1 more source
Crystals, 2016 Cocrystallization could improve most physicochemical properties of specific active pharmaceutical ingredients, which has great potential in pharmaceutical development.
Yong Du, Qiang Cai, Jiadan Xue, Qi Zhang
doaj +1 more source
Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications [PDF]
Crystal Growth & Design, 2018 peer ...
Maryam Karimi-Jafari +3 more
openaire +1 more source