Results 31 to 40 of about 23,789 (261)
Urea as a Cocrystal Former—Study of 3 Urea Based Pharmaceutical Cocrystals [PDF]
Pharmaceutics, 2021 Cocrystallization is commonly used for its ability to improve the physical properties of APIs, such as solubility, bioavailability, compressibility, etc. The pharmaceutical industry is particularly interested in those cocrystals comprising a GRAS former in connection with the target API.
Fucheng Leng, Koen Robeyns, Tom Leyssens
openaire +4 more sources
Crystals, 2015 Liquid-assisted grinding was employed to generate a cocrystal of adefovir dipivoxil (AD) and glutaric acid (GLU), which had not been successfully obtained through solution crystallization.
Sungyup Jung, Insil Choi, Il Won Kim
doaj +1 more source
Investigation of the Formation Process of Two Piracetam Cocrystals during Grinding
Pharmaceutics, 2011 Cocrystal formation rates during dry grinding and liquid-assisted grinding were investigated by X-ray powder diffractometry and Raman spectroscopy. Two polymorphic forms of piracetam were used to prepare known piracetam cocrystals as model substances, i ...
Keith Gordon +7 more
doaj +1 more source
Mechanistic and kinetic insight into spontaneous cocrystallisation of isoniazid and benzoic acid [PDF]
, 2015 Solid-state cocrystallisation is of contemporary interest, because it offers an easy and efficient way to produce cocrystals, which are recognized as prospective pharmaceutical materials.
Fabian, Laszlo +5 more
core +1 more source
Uracil Derivatives for Halogen-Bonded Cocrystals [PDF]
International Journal of Molecular Sciences, 2021 Among non-covalent interactions, halogen bonding is emerging as a new powerful tool for supramolecular self-assembly. Here, along with a green and effective method, we report three new halogen-bonded cocrystals containing uracil derivatives and 1,2,4,5-tetrafluoro-3,6-diiodobenzene as X-bond donor coformer.
Mónica Benito +4 more
openaire +4 more sources
Crystals, 2016 Cocrystallization could improve most physicochemical properties of specific active pharmaceutical ingredients, which has great potential in pharmaceutical development.
Yong Du, Qiang Cai, Jiadan Xue, Qi Zhang
doaj +1 more source
The curious case of (caffeine).(benzoic acid): how heteronuclear seeding allowed the formation of an elusive cocrystal [PDF]
, 2013 Cocrystals are modular multicomponent solids with exceptional utility in synthetic chemistry and materials science. A variety of methods exist for the preparation of cocrystals yet, some promising cocrystal phases have proven to be intractable synthetic ...
Bucar, Dejan-Kresimir +8 more
core +1 more source
Celecoxib cocrystal polymorphs† [PDF]
Acta Crystallographica Section A Foundations and Advances, 2014 Celecoxib (CEL) is a well-known nonsteroidal anti-inflammatory drug (NSAID) and selectively used from the cocxib family. It is a specific COX-2 inhibitor for pain and inflammation without inhibiting COX-1. A major downside of this popular NSAID is its poor aqueous solubility (9 mg L–1), which limits bioavailability (40%). Several methods were attempted
Geetha Bolla +2 more
openaire +1 more source
Molecular dynamics application of cocrystal energetic materials: A review
Nanotechnology Reviews, 2022 Cocrystallization is an important method to obtain high-energy and low-sensitivity explosives. Therefore, the synthesis, structures, and properties of cocrystal energetic materials have become a highly active research topic.
Wang Fuping +5 more
doaj +1 more source
A 2:1 cocrystal of 6,13-dihydropentacene and pentacene [PDF]
, 2002 6,13-Dihydropentacene and pentacene cocrystallize in a ratio of 2:1, i.e. C22H16·0.5C22H14, during vapour transport of commercial pentacene in a gas flow.
Baas, Jacob, +6 more
core +5 more sources