Results 61 to 70 of about 23,789 (261)
HeliyonIn this paper, cocrystal polymorphs of RS-ibuprofen (RS-IBU), S (+)-ibuprofen (S(+)-IBU), R (−)-ibuprofen (R(−)-IBU) with nicotinamide (NIC) were synthesized by different methods. RS-IBU is a chiral drug with only one chiral center in the molecule, which
Yaqi Jing +7 more
doaj +1 more source
Crystals, 2019 Pure theophylline-benzoic acid cocrystal was prepared via slurry and cooling crystallization in solution to overcome the disadvantages of existing preparation methods.
Yaohui Huang +8 more
doaj +1 more source
Decreasing the hygroscopicity of ammonium dinitramide (ADN) through cocrystallization
Energetic Materials Frontiers, 2022 To decrease the hygroscopicity of ADN—a energetic oxidizer, this study developed a new cocrystal composed of ADN and 18C6 (18-crown-6) at a 1:1 M ratio through cocrystallization using the solvent evaporation method.
Shen Qiao, Hong-zhen Li, Zong-wei Yang
doaj +1 more source
Mechanochemical Synthesis of Pharmaceutical Cocrystal Suspensions via Hot Melt Extrusion: Feasibility Studies and Physicochemical Characterisation [PDF]
, 2016 Engineered cocrystals offer an alternative solid drug form with tailored physicochemical properties. Interestingly, although cocrystals provide many new possibilities, they also present new challenges, particularly in regard to their design and large ...
Andrews, Gavin P. +5 more
core +1 more source
Cocrystal Transition Points: Role of Cocrystal Solubility, Drug Solubility, and Solubilizing Agents [PDF]
Molecular Pharmaceutics, 2015 In this manuscript we bring together concepts that are relevant to the solubilization and thermodynamic stability of cocrystals in the presence of drug solubilizing agents. Simple equations are derived that allow calculation of cocrystal solubilization and transition point solubility.
Maya P, Lipert +1 more
openaire +2 more sources
Charge Transport in Ternary Charge‐Transfer Solid Solution Single Crystals
Advanced Functional Materials, EarlyView.This study deconvolutes the roles of indirect (superexchange) and direct electronic coupling on charge transport in single crystals of an organic charge‐transfer molecular semiconductor (OSC). This model system elegantly demonstrates that structural defects introduced by chemical dopants play a significant role in the electronic performance ...
Jonathan C. Novak +7 more
wiley +1 more source
Optimized solubility and bioavailability of genistein based on cocrystal engineering
Natural Products and Bioprospecting, 2023 With various potential health-promoting bioactivities, genistein has great prospects in treatment of a series of complex diseases and metabolic syndromes such as cancer, diabetes, cardiovascular diseases, menopausal symptoms and so on.
Zhipeng Wang +10 more
doaj +1 more source
Complete Cocrystal Formation during Resonant Acoustic Wet Granulation: Effect of Granulation Liquids
Pharmaceutics, 2021 The manufacturing of solid pharmaceutical dosage forms composed of cocrystals requires numerous processes during which there is risk of dissociation into parent molecules.
Ryoma Tanaka +5 more
doaj +1 more source
Kinetics and Inhibition Studies of the L205R Mutant of cAMP-Dependent Protein Kinase Involved in Cushing’s Syndrome [PDF]
, 2018 Overproduction of cortisol by the hypothalamus–pituitary–adrenal hormone system results in the clinical disorder known as Cushing\u27s syndrome. Genomics studies have identified a key mutation (L205R) in the α‐isoform of the catalytic subunit of cAMP ...
Ellis, Keith C. +3 more
core +2 more sources
Thermally Activated Delayed Fluorescence in Phase‐Separated Nanostructures
Advanced Functional Materials, EarlyView.A supramolecular, phase‐separation driven strategy yields charge transfer (CT) complexes from alternating electron‐deficient pyromellitic diimide and electron‐rich 4,5‐dibromoveratrole. The resulting CT complexes self‐assemble into lamellar nanosheets with nanometer‐sized domains that exhibit thermally activated delayed fluorescence (TADF) at room ...
Bart W.L. van den Bersselaar +8 more
wiley +1 more source