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Mitigating Drug Stability Challenges Through Cocrystallization
AAPS PharmSciTech, 2023Drug stability plays a significant role in the pharmaceutical industry from early-phase drug discovery to product registration as well as the entire life cycle of a product. Various formulation approaches have been employed to overcome drug stability issues.
Jamshed Haneef +3 more
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Pharmaceutical cocrystallization techniques. Advances and challenges
International Journal of Pharmaceutics, 2018Cocrystals are homogenous (single-phase) crystalline structures composed by two or more components in a definite stoichiometric ratio bonded together by noncovalent bonds. Pharmaceutical industry has been showing interest in cocrystals due to their ability to improve active pharmaceutical ingredients (API's) properties, such as solubility, dissolution,
Marisa, Rodrigues +3 more
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Cocrystallization of Atomically Precise Nanoclusters
ACS Materials Letters, 2020Of the great classes of nanocluster crystallization, “cocrystallization” has gained significant attention due to its elucidation of both intracluster structures and intercluster packing modes.
Xi Kang, Manzhou Zhu
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Cocrystallization for successful drug delivery
Expert Opinion on Drug Delivery, 2012Cocrystallization is an effective crystal engineering approach for modifying the crystal structure and properties of drugs. The number of examples of solving drug formulation and manufacture problems by cocrystallization is rapidly growing. An updated review that systematically examines the cocrystal research in the context of drug delivery is timely ...
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Cocrystallization and polymer miscibility
Journal of Applied Polymer Science, 1980AbstractLow‐density polyethylene was blended in various proportions with an ethylene/propylene/1,4‐hexadiene copolymer having an ethylene/propylene mole ratio of 4.5 and a low level of crystallinity. The DSC melting peak of polyethylene was decreased, the unit cell was expanded, and the spherulitic development was disturbed.
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Cocrystallization of Artemisinin and Amodiaquine Hydrochloride
The Thai Journal of Pharmaceutical Sciences, 2015Artemisinin (ART) and amodiaquinedihydrochloride dihydrate (AQD) was selected as model host and guest molecules in the study. Cocrystallization of ART and AQD at mole ratio of 1:1 by temperature change technique using ethanol, new structure was found, ...
Wiriyaporn Sirikun +2 more
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Improving solubility of fisetin by cocrystallization
CrystEngComm, 2014Fisetin, a naturally occurring polyphenolic compound, has a proven record of in vitro demonstrated anti-carcinogenic, anti-inflammatory and antiviral properties, yet similarly to many promising APIs, its in vivo administration is complicated by low aqueous solubility and unfavourable pharmacokinetics.
Michał Sowa +2 more
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Concomitant cocrystallization on engineered surfaces
CrystEngComm, 2013Engineered self-assembled monolayer (SAM) substrates were successfully illustrated as a high throughput polymorph screening method for cocrystals. In this study, we have obtained new polymorphs of the cocrystals of caffeine and oxalic acid (2 : 1 molar ratio).
Xingyi Shi +3 more
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Screening for Cocrystallization Tendency: The Role of Intermolecular Interactions
The Journal of Physical Chemistry B, 2008Pharmaceutical cocrystals have rapidly emerged as a new class of API solids with great promise and advantages. Much work has been focused on exploring the crystal engineering and design strategies that facilitate formation of cocrystals of APIs and ligands/cocrystal formers.
He, G. +4 more
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Large-Periodicity Two-Dimensional Crystals by Cocrystallization
Nano Letters, 2006Patterning surfaces with features on the low end of the nanoscale can efficiently be accomplished with physisorbed monolayers. Here, cocrystallization is revealed as a powerful approach toward dramatically increasing the periodicity of surface features and expanding the length scale on which these patterns can form.
Katherine E, Plass +3 more
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