Results 51 to 60 of about 10,442 (249)

Three new hydrochlorothiazide cocrystals: Structural analyses and solubility studies [PDF]

, 2016
YesHydrochlorothiazide (HCT) is a diuretic BCS class IV drug with poor aqueous solubility and low permeability leading to poor oral absorption. The present work explores the cocrystallization technique to enhance the aqueous solubility of HCT.
Aakeröy, Aitipamula, Aitipamula, Aitipamula, Aitipamula, Animesh Ghosh, Bag, Borba, Braga, C. Malla Reddy, Chadha, Chadha, Chadha, Chan, Clarke, Desiraju, Dolomanov, El-Gizawy, Fandaruff, Ghosh, Ghosh, Ghosh, Gonçalves, Gopi, Gwak, Hancock, Kadam, Khan, Krishna, Leuner, Li, Martins, Mureşan-Pop, Ni, Palatinus, Pires, Qiao, Rajewski, Ramesh Devarapalli, Rao Khandavilli, Rasenack, Remenar, Saha, Sanphui, Sanphui, Sarma, Serajuddin, Sheldrick, Subham Ranjan, Sudeshna Kundu, Swapna, Vangala, Vangala, Vasconcelos, Vasisht, Venu R. Vangala, Vyas, Wang   +57 more
core   +1 more source

Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium

Pharmaceutics, 2018
Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and cannot be developed into a pharmaceutical formulation due to their poor aqueous ...
Indumathi Sathisaran, Sameer Vishvanath Dalvi   +1 more
doaj   +1 more source

Engineering and manufacturing of pharmaceutical co-crystals : a review on solvent-free manufacturing technologies [PDF]

, 2016
Design and synthesis of pharmaceutical cocrystals have received great interest in the recent years. Cocrystallization of drug substances offer a tremendous opportunity for the development of new drug products with superior physical and pharmacological ...
Douroumis, D., Lamprou, D. A., Ross, S. A.   +2 more
core   +1 more source

Self-assembling behavior in decane solution of potential wax crystal nucleators based on poly(co-olefins) [PDF]

, 2002
The control of the precipitation and gelation of long chain paraffins from oil remains an enduring technological challenge regarding the processing and recovery of refined fuels and waxy crudes.
Fetters, L. J., Lin, M., Richter, D., Schwahn, D., Symon, C., Wright, P. J.   +5 more
core   +1 more source

Pharmaceutical cocrystal and their role in improving solid state properties of active pharmaceutical ingredients

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2023
Cocrystallization is an emerging approach for improving physico-chemical characteristics of an active pharmaceutical ingredient (API) for instance dissolution rate, solubility, stability in addition to mechanical properties without affecting their ...
Ameera A Radhi, Iman S Jaafar, Noor S Jaafar, Sarah M Faisal   +3 more
doaj   +1 more source

Identification of a new cocrystal of citric acid and paracetamol of pharmaceutical relevance [PDF]

, 2011
Cocrystals have been increasingly recognized as an attractive alternative delivery form for solid drug products. In this work, Raman spectroscopy, X-ray powder diffraction/X-ray crystallography, and differential scanning calorimetry have been used to ...
Aakeroy, Berry, Bettinetti, Bickley, Caira, Caira, Childs, Desiraju, El-Shahawy, Etter, Etter, Etter, Etter, H. G. M. Edwards, He, I. J. Scowen, Karki, Kauffman, Lemmerer, M. A. Elbagerma, Morissette, Myz, Nangia, Nichols, Oswald, Oswald, Rao, Rodriguez-Spong, Schantz, Sheikh, T. Munshi, Vishweshwar, Vishweshwar, Wenger, Weyna   +34 more
core   +1 more source

2D Cocrystallization from H-Bonded Organic Ferroelectrics

The Journal of Physical Chemistry Letters, 2016
The synthesis of 2D H-bonded cocrystals from the room-temperature ferroelectric organics croconic acid (CA) and 3-hydroxyphenalenone (3-HPLN) is demonstrated through self-assembly on a substrate under ultrahigh vacuum. 2D cocrystal polymorphs of varied stoichiometry were identified with scanning tunneling microscopy, and one of the observed structural ...
Kunkel, Donna A., Hooper, James, Bradley, Benjamin, Schlueter, Lisa, Rasmussen, Tom, Costa, Paulo, Beniwal, Sunit, Ducharme, Stephen, Zurek, Eva, Enders, Axel   +9 more
openaire   +4 more sources

Recent Advances in Pharmaceutical Cocrystals: A Focused Review of Flavonoid Cocrystals

Molecules, 2023
Cocrystallization is currently an attractive technique for tailoring the physicochemical properties of active pharmaceutical ingredients (APIs). Flavonoids are a large class of natural products with a wide range of beneficial properties, including ...
Jia Xu, Qin Shi, Yanan Wang, Yong Wang, Junbo Xin, Jin Cheng, Fang Li   +6 more
doaj   +1 more source

Introductory lecture: Mechanochemistry, a versatile synthesis strategy for new materials. [PDF]

, 2014
Mechanochemistry deals with reactions induced by the input of mechanical energy - for example by impacts within a vibratory ball mill. The technique has a long history with significant contributions from Ostwald, Carey Lea and, notably, Faraday ...
Eddleston, Mark D, Jones, William
core   +1 more source

Mechanochemical Synthesis of Pharmaceutical Cocrystal Suspensions via Hot Melt Extrusion: Feasibility Studies and Physicochemical Characterisation [PDF]

, 2016
Engineered cocrystals offer an alternative solid drug form with tailored physicochemical properties. Interestingly, although cocrystals provide many new possibilities, they also present new challenges, particularly in regard to their design and large ...
Andrews, Gavin P., Jones, David S., Li, Shu, McCoy, Colin P., Tian, Yiwei, Yu, Tao   +5 more
core   +1 more source