Results 61 to 70 of about 10,442 (249)

A new crystalline daidzein-piperazine salt with enhanced solubility, permeability, and bioavailability

Frontiers in Pharmacology
To overcome the poor solubility, permeability, and bioavailability of the plant isoflavone daidzein (DAI), a novel salt of DAI with anhydrous piperazine (PIP) was obtained based on cocrystallization strategy.
Jiacheng Meng, Chenxu Qiu, Chenyue Lu, Xin He, Xinghua Zhao   +4 more
doaj   +1 more source

Metalloprotein Crystallography: More than a Structure [PDF]

, 2015
Metal ions and metallocofactors play important roles in a broad range of biochemical reactions. Accordingly, it has been estimated that as much as 25–50% of the proteome uses transition metal ions to carry out a variety of essential functions.
Bowman, Sarah E. J., Drennan, Catherine L., Rabb, Jennifer   +2 more
core   +1 more source

Space Group Modulated Upconversion and Mechanoluminescence in [YbEu] Cocrystal Complexes

Advanced Optical Materials, EarlyView.
We report here a space group regulation strategy to optimize both upconversion and mechanoluminescence in cocrystal assemblies, representing the first example of integrating these two properties within a single lanthanide complex material. ABSTRACT Lanthanide complexes exhibiting stimuli‐responsive luminescence, such as upconversion (UC) and ...
Wei Sun, Qi'an Zhang, Peng Fan, Fan Yin, Chong‐Bin Tian, Ke‐Han Tang, Xiao‐Qing Guo, Xiao‐Fang Duan, Dengfeng Peng, Qing‐Fu Sun   +9 more
wiley   +1 more source

Cocrystallization of Binary Silver Clusters Into Supramolecular Assembly to Regulate Aggregation‐Induced Emission and Thermally Activated Delayed Fluorescence

Aggregate
Aggregation‐induced emission (AIE) and thermally activated delayed fluorescence (TADF) are two optoelectronic properties with great potential for applications.
Wei‐Yi Liang, Hai‐Ling Wang, Peng‐Xu Lu, Pei‐Yu Liao, Wei Deng, Jian‐Hua Jia, Ming‐Liang Tong   +6 more
doaj   +1 more source

Thermodynamic investigation of carbamazepine-saccharin co-crystal polymorphs [PDF]

, 2017
YesPolymorphism in active pharmaceutical ingredients (APIs) can be regarded as critical for the potential that crystal form can have on the quality, efficacy and safety of the final drug product.
Aitipamula, Aitipamula, Aitipamula, Alhalaweh, Anant Paradkar, Azizi, Bag, Bauer, Benjamin Whiteside, Bernstein, Buanz, Burger, Burger, Cassidy, Chow, Dhumal, Duggirala, Duggirala, Eddleston, Fleischman, Good, Grant, Gu, Hickey, Hilfiker, Hong, Jung, Karki, Li, Maeno, Mangin, McNamara, Niten Jadav, Pagire, Porter, Qiu, Rager, Ranjan, Remenar, Sarkar, Shan, Sheikh, Sudhir K. Pagire, Sun, Trask, Trask, Vangala, Vangala, Vangala, Variankaval, Venu R. Vangala, Vishwehwar   +51 more
core   +1 more source

Utilizing Sulfoxide···Iodine Halogen Bonding for Cocrystallization

Crystal Growth & Design, 2012
The propensity of a range of different sulfoxides and sulfones to cocrystallize with either 1,2- or 1,4-diiodotetrafluorobenzene, via I···O=S halogen bonding, was investigated. Cocrystallization occurred exclusively with 1,4-diiodotetrafluorobenzene in either a 1:1 or 1:2 stoichiometry of the organohalide and the sulfoxide, respectively, depending on ...
Eccles, Kevin S., Morrison, Robin E., Stokes, Stephen P., O'Mahoney, Graham E., Hayes, John A., Kelly, Dawn M., O'Boyle, Noel M., Fábián, László, Moynihan, Humphrey A., Maguire, Anita R., Lawrence, Simon E.   +10 more
openaire   +3 more sources

DISSOLUTION ENHANCEMENT OF LANSOPRAZOLE USING COCRYSTALLIZATION

International Journal of Applied Pharmaceutics, 2020
Objective: Lansoprazole (LPZ) is a Biopharmaceutics Classification System Class II drug. It has low solubility and high permeability, so its rate ofdissolution is a rate-limiting step for drug absorption. This study aimed to improve the dissolution rate of LPZ by forming cocrystals, using nicotinamide(NCT) as the conformer.Methods: Cocrystals of LPZ ...
SILVIA SURINI, DIAN NOVITASARI, ARRY YANUAR   +2 more
openaire   +2 more sources

Cocrystal formation by Ionic liquid-assisted grinding: Case study with cocrystals of caffeine [PDF]

, 2018
iquid assisted grinding using imidazolium-based ionic liquids (IL-AG) was found to be effective in isolation of cocrystals and cocrystal polymorphs. Isolation of specific polymorphs of caffeine–citric acid (CAF–CA) and caffeine–glutaric acid (CAF–GLU ...
Meyerson, A. S., Mukherjee, Arijit, Rogers, Robin D.   +2 more
core   +1 more source

Next Generation Hosts for Protein Recognition, Assembly and More

Chemistry – A European Journal, EarlyView.
The original design of synthetic receptors for proteins was based on macrocycles with a hydrophobic core and a polar/charged periphery. This design, geared towards protein recognition, facilitates receptor self‐assembly. Macrocycle oligomerization, in turn, contributes to protein assembly as evidenced in many cocrystal structures.
Peter B. Crowley
wiley   +1 more source

Preparation, characterization and evaluation of aspirin: benzoic acid cocrystals with enhanced pharmaceutical properties

Future Journal of Pharmaceutical Sciences, 2020
Background The cocrystallization process in pharmaceuticals has gained widespread attention as a recent method of modifying physicochemical properties without altering the pharmacological characteristics of drugs.
Braham Dutt, Manjusha Choudhary, Vikas Budhwar   +2 more
doaj   +1 more source