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Advanced methodologies for cocrystal synthesis
Advanced Drug Delivery Reviews, 2017Pharmaceutical cocrystals are multicomponent systems composed of two or more molecules and held together by H-bonding. Currently, cocrystals provide exciting opportunities in the pharmaceutical industry for the development and manufacturing of new medicines by improving poor physical properties of Active Pharmaceutical Ingredients (APIs) such as ...
Dennis Douroumis +2 more
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2017
The aim of this project is to improve cocrystal screening and solubility prediction methods.
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The aim of this project is to improve cocrystal screening and solubility prediction methods.
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The role of cocrystals in pharmaceutical science
Drug Discovery Today, 2008Pharmaceutical cocrystals, a subset of a long known but little-studied class of compounds, represent an emerging class of crystal forms in the context of pharmaceutical science. They are attractive to pharmaceutical scientists because they can significantly diversify the number of crystal forms that exist for a particular active pharmaceutical ...
Ning, Shan, Michael J, Zaworotko
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2017
The aim of this project is to improve solubility and dissolution rate of active pharmaceutical ingrednient via cocrystallization.
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The aim of this project is to improve solubility and dissolution rate of active pharmaceutical ingrednient via cocrystallization.
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Pharmaceutical cocrystals: walking the talk
Chemical Communications, 2016From Saridon to Entresto: the journey of pharmaceuticals from the first drug–drug combination of propyphenazone and pyrithyldione in 1937 (left) to the most recent monosodium sacubitril and disodium valsartan in 2015 (right).
Geetha, Bolla, Ashwini, Nangia
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On the Design of Radical–Radical Cocrystals
Angewandte Chemie, 2018AbstractFormation of radical–radical cocrystals is an important step towards the design of organic ferrimagnets. We describe a simple approach to generate radical–radical cocrystals through the identification and implementation of well‐defined supramolecular synthons which favor cocrystallization over phase separation. In the current paper we implement
Mitchell A. Nascimento +6 more
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Journal of Pharmaceutical Sciences, 2014
In previous studies, cocrystals have been shown to be susceptible to dissociation at high humidity because of differences in the solubilities of the two coformer molecules, especially when these molecules can form hydrates. Contrastingly, however, the propensity of the pharmaceutically active compound caffeine to hydrate formation is reduced by ...
Mark D, Eddleston +2 more
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In previous studies, cocrystals have been shown to be susceptible to dissociation at high humidity because of differences in the solubilities of the two coformer molecules, especially when these molecules can form hydrates. Contrastingly, however, the propensity of the pharmaceutically active compound caffeine to hydrate formation is reduced by ...
Mark D, Eddleston +2 more
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Cocrystal Formation between Chiral Compounds: How Cocrystals Differ from Salts
Crystal Growth & Design, 2014A cocrystal screening of a series of chiral target compounds was performed in order to investigate the propensity for two optically active compounds to cocrystallize in an enantiospecific manner. Thirteen novel cocrystal systems were identified, out of which 11 are enantiospecific and two present a diastereomeric cocrystal pair, yielding a total of 15 ...
Springuel, Géraldine +4 more
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