Results 81 to 90 of about 7,051 (200)
Pharmaceutical Cocrystals and Their Physicochemical Properties [PDF]
Crystal Growth & Design, 2009 This review article will highlight and discuss the advances made over the last 10 years pertaining to physical and chemical property improvements through pharmaceutical cocrystals and, hopefully, draw closer the fields of crystal engineering and pharmaceutical sciences.
Schultheiss, Nate, Newman, Ann
openaire +2 more sources
Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods
Chirality, Volume 38, Issue 7, July 2026.Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz +1 more
wiley +1 more source
European Journal of Inorganic Chemistry, Volume 29, Issue 17, 17 June 2026.Intramolecular (RO)2PO→Halogen interaction versus intermolecular (RO)2PO···HOH hydrogen bonds. Although the O···I distance is shorter than the sum of the van der Waals radii of the atoms involved, there is no covalency involved in this interaction.
David Mross +6 more
wiley +1 more source
, 2021 The ability to rationally design and predictably construct crystalline solids has been the hallmark of crystal engineering research over the past two decades. When building higher-order multicomponent cocrystals (i.e.
Xiaoyan, Shi +10 more
core +1 more source
Pharmaceutical Cocrystals of Niclosamide
, 2016 Niclosamide (NCL) is an anthelmintic BCS class II drug of low solubility and high permeability. Pharmaceutical cocrystals of NCL were prepared with GRAS molecules, such as caffeine (CAF), urea (URE), p-aminobenzoic acid (PABA), theophylline (THPH ...
Ashwini Nangia (1400761) +2 more
core +2 more sources
ChemistryOpen, 2019 The halogen bond has previously been explored as a versatile tool in crystal engineering and anion coordination chemistry, with mechanochemical synthetic techniques having been shown to provide convenient routes towards cocrystals. In an effort to expand
Vincent M. Morin +4 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 11, 15 June 2026.We developed new derivatives of the cancer drug ponatinib, significantly reducing and altering its spectrum of target kinases. Compound 5 retained the efficacy in inhibiting the colony formation of MDA‐MB‐231 cells and acted primarily on B‐Raf and Flt‐1 as its main targets in a kinase panel.
Tobias Betzholz +7 more
wiley +1 more source
Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers
Pharmaceutics, 2019 The effect of hydroxypropyl methylcellulose (HPMC) and methylcellulose (Methocel® 60 HG) on the dissolution behavior of two cocrystals derived from nitazoxanide (NTZ), viz., nitazoxanide-glutaric acid (NTZ-GLU, 1:1) and nitazoxanide-succinic acid ...
Reynaldo Salas-Zúñiga +6 more
doaj +1 more source
Aggregate, Volume 7, Issue 6, June 2026.A pair of π‐extended chiral triangular prisms based on pyromellitic diimide is synthesized from enantiopure macrocyclic precursors. They exhibit orange fluorescence and solvent‐dependent self‐assembly, enabling chiroptical inversion and amplification with |glum| values up to 1.15 × 10−2. Single‐crystal structures reveal solvent‐controlled conformations
Si‐Dan Guo +8 more
wiley +1 more source