Results 71 to 80 of about 3,347 (175)

Stafib‐2‐CR: an Improved Nanomolar and Selective Inhibitor of the Transcription Factor STAT5b Developed by Conformational Restriction of Stafib‐2

Chemistry – A European Journal, Volume 32, Issue 26, 11 July 2026.
Conformational restriction strategies to increase the activity and selectivity of the STAT5b inhibitor Stafib‐2 are presented. The best conformationally restricted inhibitor Stafib‐2‐CR has threefold higher activity against STAT5b than Stafib‐2. A cell‐permeable prodrug of Stafib‐2‐CR inhibits phosphorylation of STAT5b in cultured human leukemia cells ...
Theresa Münzel, Angela Berg, Christoph Protzel, Sylvie Schäfer, Alexander Jensen‐Feinhals, Thorsten Berg   +5 more
wiley   +1 more source

Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium

Pharmaceutics, 2018
Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and cannot be developed into a pharmaceutical formulation due to their poor aqueous ...
Indumathi Sathisaran, Sameer Vishvanath Dalvi   +1 more
doaj   +1 more source

Application of Twin Screw Extrusion in the Manufacture of Cocrystals, Part I: Four Case Studies

Pharmaceutics, 2011
The application of twin screw extrusion (TSE) as a scalable and green process for the manufacture of cocrystals was investigated. Four model cocrystal forming systems, Caffeine-Oxalic acid, Nicotinamide-trans cinnamic acid, Carbamazepine-Saccharin, and ...
Karthik Nagapudi, Fernando Alvarez-Núñez, Robert Saw, Cesar Medina, Dominick Daurio   +4 more
doaj   +1 more source

Daidzein cocrystals: An opportunity to improve its biopharmaceutical parameters

Heliyon, 2019
The present study involves the contribution of cocrystallization towards the modification of the biopharmaceutical parameters of poorly watersoluble plant-originated isoflavone, daidzein (DAID). The cocrystals were prepared with GRAS status coformers i.e.
Yashika Bhalla, Kunal Chadha, Renu Chadha, Maninder Karan   +3 more
doaj   +1 more source

PHARMACEUTICAL COCRYSTALS

UPI Journal of Chemical and Life Sciences
Low aqueous solubility and concomitant oral bioavailability are the major glitches found in converting the active pharmaceutical ingredients to new pharmaceutical products. Many methods are in existence to improve the solubility of poorly water-soluble drugs.
Vinod Kumar K, Vyshnavi K, Reethi N, Reethi N, Siddardh H, Vaikunteswar A   +5 more
openaire   +1 more source

Energetic cocrystals – structural studies of nitrotriazolone salts and cocrystals [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2013
Hayleigh J. Lloyd, S. Corless, C. R. Pulham   +2 more
openaire   +1 more source

The cocrystals of isorhamnetin and isoliquiritigenin with 4,4'-bipyridine: system characterization, stability, dissolution and anticancer activity. [PDF]

RSC Adv
Liu Y, Lei J, Li T, Zhong A, Zhu Z, Lu J, Wang Z, Zhao P, Wu Z.   +8 more
europepmc   +1 more source

Systematic Scale-Up of Mechanochemical Paracetamol-Oxalic Acid Cocrystal Synthesis across Multiple Milling Technologies. [PDF]

Org Process Res Dev
Schöbel JH, Gopinath D, Felderhoff M.
europepmc   +1 more source

Heavy-atom functionalization promotes triplet-assisted charge-transfer exciton transport in organic cocrystals. [PDF]

Nat Commun
Xiao Y, Wei Y, Zhang M, Cai R, Liu X, Xu P, Jin S, Leng J, Tian W.   +8 more
europepmc   +1 more source

Crystals as Rockets: Modulation of the Salient Temperature in Cocrystals by Solvent Mixture Composition. [PDF]

Angew Chem Int Ed Engl
Hernández-Morales EA, Barreto-Hernández D, Galicia-Badillo D, Toscano RA, García-Aguilera ME, Rodríguez-Molina B.   +5 more
europepmc   +1 more source