Results 51 to 60 of about 7,051 (200)
Solubility enhancement of carvedilol using drug–drug cocrystallization with hydrochlorothiazide
Future Journal of Pharmaceutical Sciences, 2020 Background Increasing hydrophilicity of poorly water-soluble drugs is a major challenge in drug discovery and development. Cocrystallization is one of the techniques to enhance the hydrophilicity of such drugs.
Shivarani Eesam +4 more
doaj +1 more source
ADMET and DMPK, 2019 Since there are conflicting reports in the literature on solubility and dissolution advantages of cocrystals over free forms, we systematically studied solubility and intrinsic dissolution rates of a weakly basic drug, ketoconazole, and its cocrystals ...
Jaydip M. Vasoya +2 more
doaj +1 more source
Enhanced Dissolution of Naproxen by Combining Cocrystallization and Eutectic Formation
Pharmaceutics, 2021 Improving dissolution properties of active pharmaceutical ingredients (APIs) is a critical step in drug development with the increasing occurrence of sparingly soluble APIs.
Hakyeong Kim, Soeun Jang, Il Won Kim
doaj +1 more source
Energetic Cocrystals – Structural Studies of Nitrotriazolone Salts & Cocrystals [PDF]
Acta Crystallographica Section A Foundations and Advances, 2014 Developments in energetic materials are currently focused on the requirements for safer, yet still powerful materials for uses within mining, munitions and rocket propulsion systems One strategy that can be used to achieve these desirable properties is to synthesise new molecules, but this is both time-consuming and resource-intensive. Instead, another
Hayleigh Lloyd +5 more
openaire +1 more source
Antibiotics, 2021 Cocrystallization is a promising approach to alter physicochemical properties of active pharmaceutical ingredients (hereafter abbreviated as APIs) bearing poor profile.
Noor Ul Islam +6 more
doaj +1 more source
Improvement of physicochemical parameters of acyclovir using cocrystallization approach
Brazilian Journal of Pharmaceutical SciencesAcyclovir is an antiviral drug having potent activity against the virus of herpes family and varicella zoster. Unfortunately, drug suffers very poor oral bioavailability (15-30%).
Jignasa Ketan Savjani, Chirag Pathak
doaj +1 more source
Cocrystals of Isoniazid with Polyphenols: Mechanochemical Synthesis and Molecular Structure
Crystals, 2020 Isoniazid is used as anti-tuberculosis drug which possesses functional groups capable of forming hydrogen bonds. A series of cocrystals of isoniazid (INH) with polyphenolic coformers such as catechol (CAT), orcinol (ORC), 2-methylresorcinol (MER ...
Juan Saulo González-González +6 more
doaj +1 more source
, 2022 We present SpeedMixing, a rapid blending technology, as an approach for the mechanochemical discovery and synthesis of model pharmaceutical cocrystals without the need for bulk solvents and milling/grinding media.
Hatem, Titi +6 more
core +1 more source
Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors
Advanced Science, EarlyView.This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng +12 more
wiley +1 more source
Preparation and physicochemical characterization of sildenafil cocrystals
Journal of Advanced Pharmaceutical Technology & Research, 2021 Sildenafil is a specific inhibitor of the phosphodiesterase type 5 (PDE-5) enzyme that protects cyclic guanosine monophosphate from breakdown by PDE-5. It is a biopharmaceutical categorization system Class II medication with low bioavailability because ...
Somchai Sawatdee +6 more
doaj +1 more source