Results 31 to 40 of about 7,051 (200)

Recent Advances in Pharmaceutical Cocrystals: A Focused Review of Flavonoid Cocrystals

Molecules, 2023
Cocrystallization is currently an attractive technique for tailoring the physicochemical properties of active pharmaceutical ingredients (APIs). Flavonoids are a large class of natural products with a wide range of beneficial properties, including anticancer, anti-inflammatory, antiviral and antioxidant properties, which makes them extensively studied.
Jia Xu, Qin Shi, Yanan Wang, Yong Wang, Junbo Xin, Jin Cheng, Fang Li   +6 more
openaire   +3 more sources

Cocrystals and Drug–Drug Cocrystals of Anticancer Drugs: A Perception towards Screening Techniques, Preparation, and Enhancement of Drug Properties

Crystals, 2022
The most favored approach for drug administration is the oral route. Several anticancer drugs come under this category and mostly lack solubility and oral bioavailability, which are the most common causes of inadequate clinical efficiency. Enhancing oral
Divya Dhatri Kara, Mahalaxmi Rathnanand
doaj   +1 more source

Effect of Surfactants and Polymers on the Dissolution Behavior of Supersaturable Tecovirimat-4-Hydroxybenzoic Acid Cocrystals

Pharmaceutics, 2021
(1) Background: Pharmaceutical cocrystals have attracted remarkable interest and have been successfully used to enhance the absorption of poorly water-soluble drugs.
Yumiao Feng, Yuanyuan Meng, Fangyun Tan, Lin Lv, Zhiping Li, Yuli Wang, Yang Yang, Wei Gong, Meiyan Yang   +8 more
doaj   +1 more source

Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications [PDF]

Crystal Growth & Design, 2018
peer ...
Maryam Karimi-Jafari, Luis Padrela, Gavin M. Walker, Denise M. Croker   +3 more
openaire   +1 more source

Preparation, characterization, and pharmacokinetics of rivaroxaban cocrystals with enhanced in vitro and in vivo properties in beagle dogs

International Journal of Pharmaceutics: X, 2022
Rivaroxaban (RIV) is a direct Factor Xa inhibitor anticoagulant, but the oral bioavailability of RIV is estimated to be only 60% due to its poor solubility. The aim of the present study was to improve the solubility and bioavailability of RIV.
Yuanyuan Meng, Fangyun Tan, Jiaxin Yao, Yanan Cui, Yumiao Feng, Zhiping Li, Yuli Wang, Yang Yang, Wei Gong, Meiyan Yang, Xiaolong Kong, Chunsheng Gao   +11 more
doaj   +1 more source

Preparation, characterization and evaluation of fenofibrate: benzoic acid cocrystals with enhanced pharmaceutical properties

Future Journal of Pharmaceutical Sciences, 2021
Background Cocrystallization process involved the understanding of interaction at molecular level between two molecules in context to their crystal packing and designing of new solids having improved physicochemical as well as pharmaceutical properties ...
Braham Dutt, Manjusha Choudhary, Vikas Budhwar   +2 more
doaj   +1 more source

Solution Cocrystallization: A Scalable Approach for Cocrystal Production

Crystals, 2021
With an increasing interest in cocrystals due to various advantages, demand for large-scale cocrystallization techniques is rising. Solution cocrystallization is a solvent-based approach that utilizes several single-component crystallization concepts as ...
Nitin Pawar, Anindita Saha, Neelesh Nandan, Jose V. Parambil   +3 more
doaj   +1 more source

Physical Characteristics of Cilostazol–Hydroxybenzoic Acid Cocrystals Prepared Using a Spray Drying Method

Crystals, 2020
The cocrystal formation of pharmaceuticals can improve the various physical properties of drugs, such as solubility, without the need for chemical modification of the drug substances.
Maho Urano, Megumi Kitahara, Kae Kishi, Eiichi Goto, Tatsuaki Tagami, Toshiro Fukami, Tetsuya Ozeki   +6 more
doaj   +1 more source

Obtaining Cocrystals by Reaction Crystallization Method: Pharmaceutical Applications

Pharmaceutics, 2021
Cocrystals have gained attention in the pharmaceutical industry due to their ability to improve solubility, stability, in vitro dissolution rate, and bioavailability of poorly soluble drugs. Conceptually, cocrystals are multicomponent solids that contain
Isabela Fanelli Barreto Biscaia, Samantha Nascimento Gomes, Larissa Sakis Bernardi, Paulo Renato Oliveira   +3 more
doaj   +1 more source

The effects of pH, surfactant, ion concentration, coformer, and molecular arrangement on the solubility behavior of myricetin cocrystals

Acta Pharmaceutica Sinica B, 2019
Pharmaceutical cocrystals are a promising technology that can be used to improve the solubility of poor aqueous compounds. The objective of this study was to systematically investigate the solubility of myricetin (MYR) cocrystals, including their kinetic
Shuzhen Ren, Mingyu Liu, Chao Hong, Guowen Li, Jiabin Sun, Jianying Wang, Lei Zhang, Yan Xie   +7 more
doaj   +1 more source