Results 31 to 40 of about 3,347 (175)

Charge‐Transfer Assembly of Electrically Conductive Metal–Organic Cages

Angewandte Chemie, EarlyView.
Electrically conductive and permanently porous metal–organic cages are realized using charge‐transfer assembly between electron‐donating cages and electron‐accepting molecules, which self‐assemble to create new charge transport pathways without sacrificing access to internal void space.
Kyungseop Lee, Sebastian M. Krajewski, Werner Kaminsky, Douglas A. Reed   +3 more
wiley   +2 more sources

Novel Cocrystals of Vonoprazan: Machine Learning-Assisted Discovery

Pharmaceutics, 2022
Vonoprazan (VPZ) is the first-in-class potassium-competitive acid blocker (P-CAB), and has many advantages over proton pump inhibitors (PPIs). It is administered as a fumarate salt for the treatment of acid-related diseases, including reflux esophagitis,
Min-Jeong Lee, Ji-Yoon Kim, Paul Kim, In-Seo Lee, Medard E. Mswahili, Young-Seob Jeong, Guang J. Choi   +6 more
doaj   +1 more source

Modularity and three-dimensional isostructurality of novel synthons in sulfonamide–lactam cocrystals

IUCrJ, 2015
The design of novel supramolecular synthons for functional groups relevant to drugs is an essential prerequisite for applying crystal engineering in the development of novel pharmaceutical cocrystals.
Geetha Bolla, Sudhir Mittapalli, Ashwini Nangia   +2 more
doaj   +1 more source

Solubility enhancement of carvedilol using drug–drug cocrystallization with hydrochlorothiazide

Future Journal of Pharmaceutical Sciences, 2020
Background Increasing hydrophilicity of poorly water-soluble drugs is a major challenge in drug discovery and development. Cocrystallization is one of the techniques to enhance the hydrophilicity of such drugs.
Shivarani Eesam, Jaswanth S. Bhandaru, Chandana Naliganti, Ravi Kumar Bobbala, Raghuram Rao Akkinepally   +4 more
doaj   +1 more source

Critical Analysis and Optimization of Stoichiometric Ratio of Drug-Coformer on Cocrystal Design: Molecular Docking, In Vitro and In Vivo Assessment

Pharmaceuticals, 2023
In this present research, an attempt has been made to address the influence of drug-coformer stoichiometric ratio on cocrystal design and its impact on improvement of solubility and dissolution, as well as bioavailability of poorly soluble telmisartan ...
Manami Dhibar, Santanu Chakraborty, Souvik Basak, Paramita Pattanayak, Tanmay Chatterjee, Balaram Ghosh, Mohamed Raafat, Mohammed A. S. Abourehab   +7 more
doaj   +1 more source

Urea as a Cocrystal Former—Study of 3 Urea Based Pharmaceutical Cocrystals [PDF]

Pharmaceutics, 2021
Cocrystallization is commonly used for its ability to improve the physical properties of APIs, such as solubility, bioavailability, compressibility, etc. The pharmaceutical industry is particularly interested in those cocrystals comprising a GRAS former in connection with the target API.
Fucheng Leng, Koen Robeyns, Tom Leyssens
openaire   +3 more sources

Enhanced Dissolution of Naproxen by Combining Cocrystallization and Eutectic Formation

Pharmaceutics, 2021
Improving dissolution properties of active pharmaceutical ingredients (APIs) is a critical step in drug development with the increasing occurrence of sparingly soluble APIs.
Hakyeong Kim, Soeun Jang, Il Won Kim
doaj   +1 more source

Enhancing Dissolution Rate and Antibacterial Efficiency of Azithromycin through Drug-Drug Cocrystals with Paracetamol

Antibiotics, 2021
Cocrystallization is a promising approach to alter physicochemical properties of active pharmaceutical ingredients (hereafter abbreviated as APIs) bearing poor profile.
Noor Ul Islam, Ezzat Khan, Muhammad Naveed Umar, Attaullah Shah, Muhammad Zahoor, Riaz Ullah, Ahmed Bari   +6 more
doaj   +1 more source

Investigation of possible solubility and dissolution advantages of cocrystals, I: Aqueous solubility and dissolution rates of ketoconazole and its cocrystals as functions of pH

ADMET and DMPK, 2019
Since there are conflicting reports in the literature on solubility and dissolution advantages of cocrystals over free forms, we systematically studied solubility and intrinsic dissolution rates of a weakly basic drug, ketoconazole, and its cocrystals ...
Jaydip M. Vasoya, Ankita V. Shah, Abu T.M. Serajuddin   +2 more
doaj   +1 more source

Improvement of physicochemical parameters of acyclovir using cocrystallization approach

Brazilian Journal of Pharmaceutical Sciences
Acyclovir is an antiviral drug having potent activity against the virus of herpes family and varicella zoster. Unfortunately, drug suffers very poor oral bioavailability (15-30%).
Jignasa Ketan Savjani, Chirag Pathak
doaj   +1 more source