, 2016 The reliability of solvent drop grinding (SDG), also referred to as liquid assisted grinding, wet cogrinding, or mechanochemistry, to facilitate cocrystal formation is addressed with a series of model cocrystals and pharmaceutical cocrystals.
Michael J. Zaworotko (1298718) +3 more
core +18 more sources
Cocrystals of Modafinil-Nicotinic Acid: A Novel Cocrystal for Enhanced Bioavailability [PDF]
Proceedings, 2021 In this work, we are the first to identify and report pharmaceutically effective cocrystals of the poorly soluble drug Modafinil (MOD) using a crystal engineering approach.
Tanmoy Ghosh +3 more
doaj +3 more sources
Salts, Cocrystals, and Ionic Cocrystals of a “Simple” Tautomeric Compound [PDF]
Crystal Growth & Design, 2018 We have investigated the cocrystallization behavior of AHMP (2-amino-6-methyl-1,4-dihydropyrimidin-4-one) with a series of acids and imide coformers. Being a base able to tautomerize, at the molecular level, AHMP may exist as three different neutral tautomers or, if protonated, in the form of several cationic species.
Ting Wang +6 more
openaire +4 more sources
Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs
Pharmaceutics, 2018 Cocrystals can be used as an alternative approach based on crystal engineering to enhance specific physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (APIs) when the approaches to salt or polymorph formation do not meet
Anna Karagianni +2 more
exaly +3 more sources
Organic Photothermal Cocrystals: Rational Design, Controlled Synthesis, and Advanced Application
Advanced Science, 2023 Organic photothermal cocrystals, integrating the advantages of intrinsic organic cocrystals and the fascinating photothermal conversion ability, hold attracted considerable interest in both basic science and practical applications, involving ...
Ye-Tao Chen +2 more
exaly +2 more sources
Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications
Acta Pharmaceutica Sinica B, 2021 Pharmaceutical cocrystals are multicomponent systems in which at least one component is an active pharmaceutical ingredient and the others are pharmaceutically acceptable ingredients.
Minshan Guo, Xiaojie Sun, Ting Cai
exaly +3 more sources
Pharmaceutical Cocrystals in Drug-Delivery Technologies: Advances from Rational Design to Therapeutic Applications [PDF]
PharmaceuticsPharmaceutical cocrystals are a well-established class of solid-state forms that can modulate the solubility, dissolution, stability, and bioavailability of active pharmaceutical ingredients without altering their molecular identity. Although traditional
Marina Monserrat Marcos Valdez +3 more
doaj +2 more sources
Beyond Cocrystals: Hierarchical Functional Assemblies via Noncovalent Synthesis [PDF]
Advanced ScienceCocrystals are solid crystals formed by the combination of multiple components through non‐covalent interactions (NCIs). Despite their diverse structures and tunable optoelectronic properties, they cannot meet the demand for multi‐functionalization of ...
Ya‐Nan Zhu +6 more
doaj +2 more sources
Flavonoid-Based Cocrystals: A Comprehensive Study on Their Synthesis, Characterization, Physicochemical Properties and Applications [PDF]
MoleculesFlavonoids are naturally occurring compounds with reported anticancer, antimicrobial, anti-inflammatory, cardio-protective and antioxidant effects. They are increasingly incorporated in functional foods designed to promote health, enhance well-being, and
Urszula Izabela Maciołek +4 more
doaj +2 more sources
Cocrystallization of Ezetimibe with Organic Acids: Stoichiometric Optimization for Improved Solubility and Bioavailability [PDF]
PharmaceuticsBackground/Objectives: Pharmaceutical cocrystallization offers a promising strategy to enhance drug properties while preserving molecular integrity.
Ravi Maharjan +7 more
doaj +2 more sources