Results 41 to 50 of about 7,051 (200)

Continuous manufacturing of cocrystals using 3D-printed microfluidic chips coupled with spray coating [PDF]

, 2023
Using cocrystals has emerged as a promising strategy to improve the physicochemical properties of active pharmaceutical ingredients (APIs) by forming a new crystalline phase from two or more components.
Serrano López, Dolores Remedios, Anne Marie Healy, Lalatsa, Katerina, Dolores R. Serrano, Dinesh Kumar, Kumar, Dinesh, Aikaterini Lalatsa, Lalatsa, Aikaterini, Kara, Aytug, Healy, Anne Marie, Aytug Kara, Serrano, Dolores R.   +11 more
core   +1 more source

Pharmaceutical Cocrystal of Piroxicam: Design, Formulation and Evaluation [PDF]

Advanced Pharmaceutical Bulletin, 2017
Purpose: Cocrystallisation of drug with coformers is a promising approach to alter the solid sate properties of drug substances like solubility and dissolution.
Prabhakar Panzade, Giridhar Shendarkar, Sarfaraj Shaikh, Pavan Balmukund Rathi   +3 more
doaj   +1 more source

A nano-cocrystal strategy to improve the dissolution rate and oral bioavailability of baicalein

Asian Journal of Pharmaceutical Sciences, 2019
Baicalein (BE) is one of the main active flavonoids representing the variety of pharmacological effects including anticancer, anti-inflammatory and cardiovascular protective activities, but it's very low solubility, dissolution rate and poor oral ...
Jiaxin Pi, Shuya Wang, Wen Li, Dereje Kebebe, Ying Zhang, Bing Zhang, Dongli Qi, Pan Guo, Nan Li, Zhidong Liu   +9 more
doaj   +1 more source

Pharmaceutical Cocrystals: Regulatory and Strategic Aspects, Design and Development [PDF]

Advanced Pharmaceutical Bulletin, 2016
Cocrystal is a concept of the supramolecular chemistry which is gaining the extensive interest of researchers from pharmaceutical and chemical sciences and of drug regulatory agencies.
Dipak Dilip Gadade, Sanjay Sudhakar Pekamwar   +1 more
doaj   +1 more source

Push-Pull and Conventional Nitriles as Halogen Bond Acceptors in their Cocrystals with Iodo-substituted Perfluorobenzenes

, 2023
Co-crystallization of the push-pull nitriles NCNR2 (R2 = Me2 1, C4H8 2, C5H10 3, C4H8O 4) with iodo-substituted perfluorobenzenes (1,4-diiodotetrafluorobenzene – 1,4-FIB and 1,3,5-triiodotrifluorobenzene – 1,3,5-FIB), gave cocrystals 1·1,3,5-FIB, 2·1,3,5-
Rosa, Gomila, Antonio, Frontera, Vadim, Kukushkin, Yulia, Toikka, Yulia, Izotova, Nadezhda, Bokach   +5 more
core   +1 more source

Glycine‐Induced Unique Crystal Packing of Octacyanidetungstates With Strong Intermolecular Antiferromagnetic Interaction, Near‐Infrared Emission, and Second Harmonic Generation

Angewandte Chemie, EarlyView.
Glycine molecules induce a unique crystal packing into a supramolecular one‐dimensional columnar structure of octacyanidotungstates, which exhibits exceptionally strong antiferromagnetic superexchange interactions of J = −42.41(2) K between adjacent octacyanidotungstate units.
Tatsuya Konishi, Koji Nakabayashi, Kunal Kumar, Takeshi Suzuki, Kozo Okazaki, Masataka Kobayashi, Hidefumi Akiyama, Kouji Chiba, Shin‐ichi Ohkoshi   +8 more
wiley   +2 more sources

Ionic Cocrystals of Etiracetam and Levetiracetam: The Importance of Chirality for Ionic Cocrystals

Crystal Growth & Design, 2019
A striking variety of anhydrous and hydrated ionic cocrystals (ICCs) of the enantiopure antiepileptic drug (AED) levetiracetam and of its racemic intermediate etiracetam with the pharmaceutically acceptable salts CaCl2 and MgCl2 was synthesized and structurally characterized.
Lixing Song, Oleksii Shemchuk, Koen Robeyns, Dario Braga, Fabrizia Grepioni, Tom Leyssens   +5 more
openaire   +3 more sources

Novel Cocrystals of Vonoprazan: Machine Learning-Assisted Discovery

Pharmaceutics, 2022
Vonoprazan (VPZ) is the first-in-class potassium-competitive acid blocker (P-CAB), and has many advantages over proton pump inhibitors (PPIs). It is administered as a fumarate salt for the treatment of acid-related diseases, including reflux esophagitis,
Min-Jeong Lee, Ji-Yoon Kim, Paul Kim, In-Seo Lee, Medard E. Mswahili, Young-Seob Jeong, Guang J. Choi   +6 more
doaj   +1 more source

Modularity and three-dimensional isostructurality of novel synthons in sulfonamide–lactam cocrystals

IUCrJ, 2015
The design of novel supramolecular synthons for functional groups relevant to drugs is an essential prerequisite for applying crystal engineering in the development of novel pharmaceutical cocrystals.
Geetha Bolla, Sudhir Mittapalli, Ashwini Nangia   +2 more
doaj   +1 more source

Critical Analysis and Optimization of Stoichiometric Ratio of Drug-Coformer on Cocrystal Design: Molecular Docking, In Vitro and In Vivo Assessment

Pharmaceuticals, 2023
In this present research, an attempt has been made to address the influence of drug-coformer stoichiometric ratio on cocrystal design and its impact on improvement of solubility and dissolution, as well as bioavailability of poorly soluble telmisartan ...
Manami Dhibar, Santanu Chakraborty, Souvik Basak, Paramita Pattanayak, Tanmay Chatterjee, Balaram Ghosh, Mohamed Raafat, Mohammed A. S. Abourehab   +7 more
doaj   +1 more source